The Comparison of the Effects of Sevoflurane Inhalation Anesthesia and Intravenous Propofol Anesthesia on Oxidative Stress in One Lung Ventilation

Ertürk, Engin; Topaloglu, Selma; Dohman, Davut; Kutanıs, Dilek; Beşir, Ahmet; Demirci, Yücel; Kayır, Selçuk; Menteşe, Ahmet

doi:10.1155/2014/360936

Cited by 32 publications

(24 citation statements)

References 20 publications

(23 reference statements)

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“…Additionally, sevoflurane did not significantly reduce serum levels of inflammatory factors, which is consistent with previous studies 6,7 . This suggests that the protection afforded by sevoflurane administration is independent of the release of proinflammatory cytokines from activated Kupffer cells in I/R injury 28,29 .…”

Section: Serum Levels Of Inflammatory Mediatorsmentioning

confidence: 98%

Mechanisms of the beneficial effect of sevoflurane in liver ischemia/reperfusion injury

Cavalcante

Coelho²,

Machado³

et al. 2015

Acta Cir. Bras.

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PURPOSE:To evaluate the underlying mechanisms by which sevoflurane protects the liver against ischemia/reperfusion injury evaluate the mechanism by which sevoflurane exerts this protective effect. METHODS:Twenty-six rats were subjected to partial ischemia/reperfusion injury for 1h: one group received no treatment, one group received sevoflurane, and sham group of animals received laparotomy only. Four hours after reperfusion, levels of alanine and aspartate aminotransferases, tumor necrosis factor-α, and interleukins 6 and 10 were measured. Analyses of mitochondrial oxidation and phosphorylation, malondialdehyde content, histology, and pulmonary vascular permeability were performed. RESULTS:Serum levels of alanine and aspartate aminotransferases were significantly lower in the sevoflurane group compared to untreated controls (p<0.05). The sevoflurane group also showed preservation of liver mitochondrial function compared to untreated controls (p<0.05). Sevoflurane administration did not alter increases in serum levels of tumor necrosis factor-α, and interleukins 6 and 10. Sevoflurane treatment significantly reduced the coagulative necrosis induced by ischemia/reperfusion (p<0.05). Pulmonary vascular permeability was preserved in the sevoflurane group compared to untreated controls. CONCLUSION:Sevoflurane administration protects the liver against ischemia/reperfusion injury, via preservation of mitochondrial function, and also preserves lung vascular permeability.

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Section: Serum Levels Of Inflammatory Mediatorsmentioning

confidence: 98%

Mechanisms of the beneficial effect of sevoflurane in liver ischemia/reperfusion injury

Cavalcante

Coelho²,

Machado³

et al. 2015

Acta Cir. Bras.

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“…In terms of human study, there are four studies with a total of 130 participants, comparing the outcome of propofol and sevoflurane in perioperative ALI; overall, there were no significant differences in the incidence of ARDS and the reported biochemical difference is conflicting between the studies 25, 140-142 .…”

Section: Clinical Considerationsmentioning

confidence: 99%

Perioperative “remote” acute lung injury: recent update

Jin

Suen

2017

J Biomed Res

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Perioperative acute lung injury (ALI) is a syndrome characterised by hypoxia and chest radiograph changes. It is a serious post-operative complication, associated with considerable mortality and morbidity. In addition to mechanical ventilation, remote organ insult could also trigger systemic responses which induce ALI. Currently, there are limited treatment options available beyond conservative respiratory support. However, increasing understanding of the pathophysiology of ALI and the biochemical pathways involved will aid the development of novel treatments and help to improve patient outcome as well as to reduce cost to the health service. In this review we will discuss the epidemiology of peri-operative ALI; the cellular and molecular mechanisms involved on the pathological process; the clinical considerations in preventing and managing perioperative ALI and the potential future treatment options.

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“…However, after thoracic surgery there seems to be no clear relation between inflammatory markers and pulmonary morbidity as the results of clinical studies are conflicting (18)(19)(20)(21)(22).…”

Section: Type Of Anaesthesiamentioning

confidence: 99%