2015
DOI: 10.1590/s0102-865020150110000005 View full text |Buy / Rent full text
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Abstract: PURPOSE:To evaluate the underlying mechanisms by which sevoflurane protects the liver against ischemia/reperfusion injury evaluate the mechanism by which sevoflurane exerts this protective effect. METHODS:Twenty-six rats were subjected to partial ischemia/reperfusion injury for 1h: one group received no treatment, one group received sevoflurane, and sham group of animals received laparotomy only. Four hours after reperfusion, levels of alanine and aspartate aminotransferases, tumor necrosis factor-α, and inter… Show more

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“…Animals showed decreased AST and ALT levels with liver preconditioning with sevoflurane for 15 min. Previously, in this laboratory, Cavalcante et al [18] showed decreased transaminase levels with continuous sevoflurane anesthesia for about 4 h of the whole experiment. In a randomized study in liver surgery, Beck-Schimmer et al [7] showed decreased AST and ALT levels in patients preconditioned with sevoflurane before liver ischemia.…”
Section: Discussionmentioning
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“…Animals showed decreased AST and ALT levels with liver preconditioning with sevoflurane for 15 min. Previously, in this laboratory, Cavalcante et al [18] showed decreased transaminase levels with continuous sevoflurane anesthesia for about 4 h of the whole experiment. In a randomized study in liver surgery, Beck-Schimmer et al [7] showed decreased AST and ALT levels in patients preconditioned with sevoflurane before liver ischemia.…”
Section: Discussionmentioning
“…These results may have been due to treatment with PHT, which expanded the hepatic artery and the small branches of the artery in the liver, relieved the arterial spasm, increased liver perfusion, and improved the hepatic microcirculation. [14][15][16] The pathologic results revealed that a smaller hepatic artery diameter and a depressed vessel wall were observed at 30 minutes after reperfusion in the control group, and these results were not detected in other groups. 17 This finding also provides strong evidence of the occurrence of a hepatic artery spasm.…”
Section: Discussionmentioning
“…In addition, the time required for the contrast agent to reach a peak in the liver parenchyma was shorter; the AUC was larger; and the liver parenchyma was fully developed at the peak time without an obvious dark space, illustrating that the liver microcirculation perfusion had sufficiently recovered. These results may have been due to treatment with PHT, which expanded the hepatic artery and the small branches of the artery in the liver, relieved the arterial spasm, increased liver perfusion, and improved the hepatic microcirculation …”
Section: Discussionmentioning
“…Sun and Yang found that metformin improved the myocardial function of mice with heart failure following MI according to regulation of the expression of SIRT3 and PGC-1α in the mitochondrial inner membrane (58). However, mitochondrial dysfunction is not unique to MI; energy metabolism barriers can also occur in acute cerebral ischemia (59), renal ischemia (60), liver ischemia (61) and other ischemic diseases. This provides a novel direction in order to understand the process of MI, and further investigations are required.…”
Section: Discussionmentioning