2019
DOI: 10.3892/ijmm.2019.4137
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Abstract: Acute myocardial infarction (AMI) is one of the most common and life-threatening cardiovascular diseases. However, the ability to diagnose AMI within 3 h is currently lacking. The present study aimed to identify the differentially expressed proteins of AMI within 3 h and to investigate novel biomarkers using isobaric tags for relative and absolute quantitation (ITRAQ) technology. A total of 30 beagle dogs were used for establishing the MI models successfully by injecting thrombin powder and a polyethylene micr… Show more

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Cited by 6 publications
(5 citation statements)
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“…Integrated proteomic-metabolomics is a powerful combination [8] and provides a better understanding of dynamic molecular change. Some studies have reported the changes of metabolites and proteins in plasma or myocardium after MI [9][10][11]; however, the integrated proteomic-metabolomics in myocardium after an MI has not been reported. Thus, we designed an integrated proteomic-metabolomics study, to comprehensively understand the pathological changes and the mechanisms of MI.…”
Section: Introductionmentioning
confidence: 99%
“…Integrated proteomic-metabolomics is a powerful combination [8] and provides a better understanding of dynamic molecular change. Some studies have reported the changes of metabolites and proteins in plasma or myocardium after MI [9][10][11]; however, the integrated proteomic-metabolomics in myocardium after an MI has not been reported. Thus, we designed an integrated proteomic-metabolomics study, to comprehensively understand the pathological changes and the mechanisms of MI.…”
Section: Introductionmentioning
confidence: 99%
“…With iTRAQ, the protein expression levels can be compared simultaneously [16]. iTRAQ technology has been applied to muchresearch: To identify prognostic biomarkers for gastric cancer [17]; to reveal potential novel biomarkers for the early diagnosis of acute myocardial infarction within three hours [18]; to identified SAA and ACTB as potential biomarkers in patients with severe hand, foot, and mouth disease (HFMD) [19], to discover glioblastoma serum markers [20], and so on.…”
Section: Discussionmentioning
confidence: 99%
“…Quantitative proteomics has been combined in several facets to biomarker discovery in a variety of different diseases [ 98 , 99 ]. One example used iTRAQ 8‐plex tags to label serum protein digests and identify biomarkers for acute myocardial infarction [ 100 ]. iTRAQ 8‐plex was also utilized to quantify targets for breast cancer from tissue samples [ 101 ].…”
Section: Applications Of Isobaric Tagsmentioning
confidence: 99%