The comparison of resting metabolic rate between biopsy-proven non-alcoholic steatohepatitis and non-alcoholic fatty liver patients

Abstract

Background and Aim: Resting metabolic (RMR) rate was shown to be associated with chronic inflammatory conditions. In this study, we aimed to investigate whether RMR differs significantly in patients with non-alcoholic steatohepatitis (NASH) from patients with non-alcoholic fatty liver disease (NAFLD) without evidence of inflammation. Material and Methods: Forty-two biopsy-proven NASH were compared with 37 NAFLD patients, who had normal serum transaminases and no evidence of fibrosis based on transient elastography examination. In the interviews, patients' levels of physical activity and dietary habits were recorded, and bioimpedance analysis was performed. The RMRs were calculated using an indirect calorimeter. Results: RMR did not significantly differ between patients with NASH and NAFLD without steatohepatitis in both genders (p=0.695 in males, p=0.256 in females). However, only in female patients RMR rate per body weight was significantly higher in patients with NASH (22.3 [17.2-26.6] cal/kg to 20.2 [12.2-26.1] cal/kg, p=0.020). Conclusion: In conclusion, RMR was not significantly associated with steatohepatitis in patients with NAFLD. Considering the minimizing the effects of body weight, RMR rate per body weight may be used over RMR in the evaluation of the inflammatory status of the NAFLD.

Macro- and micronutrients in metabolic (dysfunction) associated fatty liver disease: association between advanced fibrosis and high dietary intake of cholesterol/saturated fatty acids

“…All the Fibroscan examinations were conducted by a single operator (YY) following the manufacturer’s instructions as described previously in detail [20]. A reliable measurement was defined as reaching at least 10 valid measurements with an interquartile range-to-median ratio of ≤0.3 [21].…”

Sustainability of diet based on moderate calorie restriction among obese patients with metabolic-associated fatty liver disease

“…Transient elastography was performed using the Fibroscan by a single operator as per the manufacturer's instructions detailed elsewhere. [21] During each examination, at least 10 valid measurements were performed and an interquartile range-to-median ratio of ≤0.3 was achieved. [22] Hepatic steatosis was defined as a controlled attenuation parameter (CAP) cut-off of ≥238 dB/m.…”

Changes in the etiology of chronic liver disease by referral to a FibroScan center: Increasing prevalence of the nonalcoholic fatty liver disease

“…LSM values derived from at least 10 valid measurements that have an IQR/ median value of ≤30% were considered reliable. [11][12][13] The cutoff values for CAP and LSM were derived from the literature (F0: ≤6.0 kPa, F1: 6.1-7.0 kPa, F2: 7.1-9.9 kPa, F3: 10.0-13.9 kPa, F4: ≥14.0 kPa; S0: <238 dB/m (<5%), S1: 238-258 dB/m (5%-33%), S2: 259-289 dB/m (34%-66%), S3: >290 dB/m (>66%). [14][15][16]…”