The comparison of preemptive analgesic effects of curcumin and diclofenac

Abstract

Abstract:Objective: Preemptive analgesia is an antinociceptive treatment that prevents central sensitization. Antinociceptive effects of diclofenac are well-known. The aim of this study was to investigate preemptive analgesic effects of curcumin and diclofenac, before acute and infl ammatory induced pain in rat model. Material and methods: Fourty eight old female (n = 6 in each group) Wistar Albino rats were included in the study. Paw movements in response to paw fl inching in response to formalin injection or thermal stimulation were compared after curcumin (400 mg kg -1 , p.o.) and diclofenac (10 mg kg -1 , i.p.) administration. Saline was used as a control. The solvent ethanol was administered in another group of rats. Preemptive analgesic effect was signifi cant in both tests when curcumin and diclofenac was administrated before the pain stimuli. Results: Oral administration of curcumin and intraperitoneal injection of diclofenac increase the response time in hot plate test and decrease the number of fl inches in formalin test (p < 0.001 vs p < 0.05). Conclusion: These results suggest that curcumin had preemptive analgesic effects on acute thermal, and infl ammatory induced pain in rats as diclofenac (Fig. 2, Ref. 35). Text in PDF www.elis.sk.

Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review

“…Nurullahoglu et al [ 176 ] suggested the preemptive analgesic effects of curcumin on acute thermal and inflammation-induced pain in female Wistar Albino rats. Furthermore, the study compared the preemptive effects of curcumin with intraperitoneal administration of diclofenac (10 mg/kg), a non-steroidal anti-inflammatory drug [ 180 ].…”

“…Diclofenac exerts controversial preemptive effects, with some studies, showing no differences in the effects in between pre- and postoperative diclofenac-treated patients undergoing laparoscopic tubal ligation [ 177 ], while other studies reported that preoperative administration of diclofenac along with ketorolac and piroxicam reduced postoperative pain in patients undergoing laparoscopy [ 181 , 182 ]. Based on Nurullahoglu et al’s [ 176 ] study, both curcumin and diclofenac exerted preemptive analgesic effects. Bulboacs et al [ 175 ] demonstrated the preemptive effects of curcumin in a rodent migraine model.…”

Differential expression of spinal &gamma;-aminobutyric acid and opioid receptors modulates the analgesic effects of intrathecal curcumin on postoperative/inflammatory pain in rats

“…Such findings suggest that the GABA and opioid receptor systems may be [5,6,24]. In addition, oral curcumin reduced the formalin-induced flinching response, thermal hyperalgesia and neuropathic pain [25][26][27]. Intravenous curcumin attenuated visceral nociception [28].…”

Anti-Inflammatory and Analgesic Effects of Curcumin Nanoparticles Associated with Diclofenac Sodium in Experimental Acute Inflammation

“…In an experimental study performed by Nurullahoglu et al [ 46 ], curcumin suspension in a dose of 400 mg/kg b.w. prepared in 5% ethanol solution, proved more potent than diclofenac alone in the early phase of pain on formalin test.…”