The comparison of magnetic circuits used in magnetic hyperthermia

Skumiel, A.; Leszczyński, Błażej; Molčan, Matúš; Τimko, M.

doi:10.1016/j.jmmm.2016.07.018

Cited by 31 publications

(25 citation statements)

References 18 publications

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“…The dT/dt versus H dependencies were subsequently fitted by a ( H/a) n function [ 51 ], where a and n are fitting parameters. If the sample includes only superparamagnetic nanoparticles (as proven by the magnetisation measurements), dT/dt = (H/a) n is a square function and n ≅ 2 [ 52 ]. Figure 6 A shows the dependence of dT/dt on the magnetic field amplitude H for the DEX x -MFs and the function of the fit.…”

Section: Resultsmentioning

confidence: 99%

“…The dependence of the SAR evolution on the MW is presented in Figure 6 B. The SAR was estimated according to the following equation [ 52 ]:

where C p is the specific heat capacity ( C p ≈ C water = 4.18 J∙K −1 ∙g −1 ), ρ S is the density of the sample (≈1021 kg∙m −3 ), m is the mass of magnetite per unit volume of the colloid (25 mg∙mL −1 ) and dT/dt is the heating rate (slope) calculated from the linear fit of the heating curves. In the case of smaller MWs (DEX 40 -MF and DEX 70 -MF), the SAR values are very low, but in the case of the DEX 150 -MF, the increase is obvious.…”

Section: Resultsmentioning

confidence: 99%

“…The dependence of the SAR evolution on the MW is presented in Figure 6B. The SAR was estimated according to the following equation [52]:…”

Section: Magnetic Hyperthermia Of Dex-coated Mnpsmentioning

confidence: 99%

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Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications

et al. 2020

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Dextran-coated magnetic nanoparticles are promising biocompatible agents in various biomedical applications, including hyperthermia and magnetic resonance imaging (MRI). However, the influence of dextran molecular weight on the physical properties of dextran-coated magnetic nanoparticles has not been described sufficiently. We synthesise magnetite nanoparticles with a dextran coating using a co-precipitation method and study their physical properties as a function of dextran molecular weight. Several different methods are used to determine the size distribution of the particles, including microscopy, dynamic light scattering, differential centrifugal sedimentation and magnetic measurements. The size of the dextran-coated particles increases with increasing dextran molecular weight. We find that the molecular weight of dextran has a significant effect on the particle size, efficiency, magnetic properties and specific absorption rate. Magnetic hyperthermia measurements show that heating is faster for dextran-coated particles with higher molecular weight. The different molecular weights of the coating also significantly affected its MRI relaxation properties, especially the transversal relaxivity r2. Linear regression analysis reveals a statistically significant dependence of r2 on the differential centrifugal sedimentation diameter. This allows the targeted preparation of dextran-coated magnetic nanoparticles with the desired MRI properties. These results will aid the development of functionalised magnetic nanoparticles for hyperthermia and MRI applications.

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Section: Resultsmentioning

confidence: 99%

“…The dependence of the SAR evolution on the MW is presented in Figure 6 B. The SAR was estimated according to the following equation [ 52 ]:

Section: Resultsmentioning

confidence: 99%

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Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications

et al. 2020

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“…Iron content was determined using a Perkin Elmer 3110 atomic absorption spectrometer (AAS; Waltham, MA, USA), content of C was measured on a FlashSmart TM elemental analyzer (Thermo Fisher Scientific; Waltham, MA, USA), and thermogravimetric analysis was performed in air flow with 10 • C/min heating rate on a Perkin Elmer TGA 7 thermogravimetric analyzer (Waltham, MA, USA) equipped with Pyris software. The heat effect of the mag.SLPs was tested under an alternating magnetic field (AMF) by homemade AC system and temperature changes were monitored by a fiber optic temperature sensor (FISO Technologies; Québec, Canada) (Skumiel et al, 2016). Magnetization of dry particles was determined using an EV9 vibrating sample magnetometer (DSM Magnetics, ADE Corp.; Lowell, MA, USA) at RT.…”

Section: Particle Characterizationmentioning

confidence: 99%

Magnetic Temperature-Sensitive Solid-Lipid Particles for Targeting and Killing Tumor Cells

et al. 2020

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Magnetic and temperature-sensitive solid lipid particles (mag. SLPs) were prepared in the presence of oleic acid-coated iron oxide (IO-OA) nanoparticles with 1-tetradecanol and poly(ethylene oxide)-block-poly(ε-caprolactone) as lipid and stabilizing surfactant-like agents, respectively. The particles, typically ∼850 nm in hydrodynamic size, showed heat dissipation under the applied alternating magnetic field. Cytotoxic activity of the mag.SLPs, non-magnetic SLPs, and iron oxide nanoparticles was compared concerning the mammalian cancer cell lines and their drug-resistant counterparts using trypan blue exclusion test and MTT assay. The mag.SLPs exhibited dose-dependent cytotoxicity against human leukemia cell lines growing in suspension (Jurkat and HL-60/wt), as well as the doxorubicin (Dox)-and vincristine-resistant HL-60 sublines. The mag.SLPs showed higher cytotoxicity toward drug-resistant sublines as compared to Dox. The human glioblastoma cell line U251 growing in a monolayer culture was also sensitive to mag.SLPs cytotoxicity. Staining of U251 cells with the fluorescent dyes Hoechst 33342 and propidium iodide (PI) revealed that mag.SLPs treatment resulted in an increased number of cells with condensed chromatin and/or fragmented nuclei as well as with blebbing of the plasma membranes. While the Hoechst 33342 staining of cell suggested the pro-apoptotic activity of the particles, the PI staining indicated the pro-necrotic changes in the target cells. These conclusions were confirmed by Western blot analysis of apoptosis-related proteins, study of DNA fragmentation (DNA laddering due to the inter-nucleosomal cleavage and DNA comets due to single strand breaks), as well as by FACS analysis of the patterns of cell cycle distribution (pre-G1 phase) and Annexin V/PI staining of the treated Jurkat cells. The induction of apoptosis or necrosis by the particles used to treat Jurkat cells depended on the dose of the particles. Production of the reactive oxygen species (ROS) was proposed as a potential mechanism of mag.SLPs-induced cytotoxicity. Accordingly, hydrogen peroxide and superoxide radical Ś więtek et al.Magnetic Solid-Lipid Particles levels in mag.SLPs-treated Jurkat leukemic cells were increased by ∼20-40 and ∼70%, respectively. In contrast, the non-magnetic SLPs and neat iron oxides did not influence ROS levels significantly. Thus, the developed mag.SLPs can be used for effective killing of human tumor cells, including drug-resistant ones.

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“…AMFG using single-layer and double-layer solenoid, Helmholtz coils, and inductor with C-shaped ferromagnetic core are the most common systems, which have been compared in [17]. The most common type is single-layer solenoid [18][19][20][21][22][23][24] on which this study is focused.…”

Section: Introductionmentioning

confidence: 99%

Design of Alternating Magnetic Field Generator for Magnetic Fluid Hyperthermia Research Application

Mohseni

Rajaei

2017

Scientia Iranica

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Abstract. Hyperthermia utilizing nanoparticles is a novel cancer therapy, which relies on the heat released when nanoparticles inside a tumor are exposed to an alternating magnetic eld. The eld strength and frequency as the main variants a ect performance of nanoparticles in heat generation. Besides characteristics of the nanoparticle, which are the main criteria for tuning amplitude and frequency of the magnetic eld generated by an Alternating Magnetic Field Generator (AMFG), several related parameters should be considered for an optimum design of AMFG. These parameters are input voltage range, copper tube resistance used in solenoid coil, coil number of turns, etc. With regard to these criteria, a design procedure of AMFG for research applications is proposed to maximize the heat released by nanoparticles. In order to validate the design, an experimental setup of AMFG is prepared, which is used for in vivo hyperthermia tests. The experimental results are shown and compared with the simulations.

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The comparison of magnetic circuits used in magnetic hyperthermia

Cited by 31 publications

References 18 publications

Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications

Influence of Dextran Molecular Weight on the Physical Properties of Magnetic Nanoparticles for Hyperthermia and MRI Applications

Magnetic Temperature-Sensitive Solid-Lipid Particles for Targeting and Killing Tumor Cells

Design of Alternating Magnetic Field Generator for Magnetic Fluid Hyperthermia Research Application

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