Design of Alternating Magnetic Field Generator for Magnetic Fluid Hyperthermia Research Application

Mohseni, Mahdi; Rajaei, Amirhossein

doi:10.24200/sci.2017.4380

Cited by 1 publication

(2 citation statements)

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“…Another common solution is to use a Full-Bridge with a capacitor in series with the load switched at the resonant frequency; commonly found in induction heating devices. In [25], an inverter is also used to develop an AMF generator using a Full-Bridge with Zero-Current Switching (ZCS). Due to the resonance of the inductive load with the resonant capacitor, relatively low voltages can be used to obtain high current, and, as a result, low voltage devices can be employed.…”

Section: Inverter For Magnetic Hyperthermiamentioning

confidence: 99%

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Configurable High-Frequency Alternating Magnetic Field Generator for Nanomedical Magnetic Hyperthermia Applications

et al. 2021

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This article shows the use of a high-frequency Full-Bridge inverter to design an alternating magnetic field generator for experimental studies on anti-cancer treatment with magnetic nanoparticles. In magnetic hyperthermia, nanoparticles are used to raise the pathological cancerous cell's temperature high enough to induce their death by apoptosis, but not as high as to destroy them by thermal ablation of the whole tissue volume, consequently leaving healthy cells alive. Conventionally, sinusoidal alternative magnetic fields are used to heat the nanoparticles, which can be more easily produced than other waveforms. However, there are no theoretical nor experimental reasons to chose the sinusoidal waveform. This work aims to develop an improved power system to study the effect of different waveforms of the magnetic field on the heat production when exciting magnetic nanoparticles, aiming at demonstrating that other waveforms can be much more efficient in producing heat than conventional sinusoids. To prove our hypothesis, we designed an inverter able to generate four waveforms at high frequencies and a fifth sinusoidal signal derived by a resonant capacitor, in the range of 100 kHz to 1 MHz and up to 10 mT of peak intensity. Also, we used SiC devices to process high currents at high switching frequencies efficiently. Additionally, to enhance the system efficiency, Zero-Voltage Switching is used to reduce switching losses and minimize electromagnetic noise and interference. The experimental results obtained with non-sinusoidal waveforms have shown a remarkable performance improvement compared to classical sine wave excitation. The nanoparticles' heat dissipation depends on the applied alternating magnetic field's signal slope, signal frequency, and peak field intensity. We conclude that further work deserves to be done to find the optimum work conditions in function of the used particle and biological environment, to test if this type of magnetic field generator could overcome the conventional system's performance.

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Section: Inverter For Magnetic Hyperthermiamentioning

confidence: 99%

“…To obtain sinusoidal shapes, a resonant capacitor is added in series with the load, as in [25]. A large current can be obtained even with relatively low input voltage values if the switching frequency is selected near the resonant frequency of the resonant tank formed by the load and the additional capacitor.…”

Section: A Operation Of the Invertermentioning

confidence: 99%