The comparison of chemerin, adiponectin and lipid profile indices in obese and non-obese adolescents

Maghsoudi, Zahra; Kelishadi, Roya; Hosseinzadeh‐Attar, Mohammad Javad

doi:10.1016/j.dsx.2016.01.020

Cited by 28 publications

(30 citation statements)

References 21 publications

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“…One explanation might be that in those studies the severity of the periodontal disease was higher, whereas in our study mostly patients with moderate periodontitis were included. In the serum, the chemerin level correlated with the BMI, which is in line with several other reports . Immunomodulatory effects of chemerin might be both inflammatory and anti‐inflammatory.…”

Section: Discussionsupporting

confidence: 91%

“…In the serum, the chemerin level correlated with the BMI, which is in line with several other reports. 38,49,50 Immunomodulatory effects of chemerin might be both inflammatory and anti-inflammatory. The potential inflammatory function of chemerin in periodontitis might be underlined by the fact that the levels of chemerin in gingival crevicular fluid 48 and saliva 51 decreased after periodontal therapy.…”

Section: Discussionmentioning

confidence: 99%

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Salivary, gingival crevicular fluid and serum levels of ghrelin and chemerin in patients with periodontitis and overweight

Jentsch

Arnold

Richter

et al. 2017

J of Periodontal Research

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Salivary, gingival crevicular fluid and serum levels of ghrelin and chemerin in patients with periodontitis and overweight

Jentsch

Arnold

Richter

et al. 2017

J of Periodontal Research

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“…As expected, the plasma concentrations of chemerin were noticeably higher in overweight patients compared with normal‐weight patients despite similar clinical findings. Our results are in line with previous publications that show BMI‐related chemerin levels systemically as well as locally (Balli et al, 2016; Jentsch et al, 2017; Maghsoudi, Kelishadi, & Hosseinzadeh‐Attar, 2016; Sledzinski et al, 2013). The plasma concentrations of chemerin in the overweight group decreased slightly but statistically noticeably, whereas this biomarker showed mostly unchanged levels in the normal‐weight group.…”

Section: Discussionsupporting

confidence: 93%

Effect of periodontal therapy on adipokine biomarkers in overweight

Matern

Koch

Petersmann

et al. 2020

J Clinic Periodontology

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Aim The aim of this study was to evaluate the effect of non‐surgical periodontal therapy on circulating levels of the systemic inflammation‐associated biomarkers orosomucoid (ORM), high‐sensitivity C‐reactive protein (hsCRP), chemerin, and retinol‐binding protein 4 (RBP4) in overweight or normal‐weight patients with periodontitis at 27.5 months after therapy. Materials and methods This exploratory subanalysis includes patients from the ABPARO‐trial (ClinicalTrials.gov NCT00707369). The per‐protocol collective provided untreated periodontitis patients with high (≥28 kg/m2) or moderate (21–24 kg/m2) BMI. Out of the per‐protocol collective, 80 patients were randomly selected and stratified for BMI group, sex, and treatment group (antibiotics/placebo), resulting in 40 overweight and normal‐weight patients. Patients received non‐surgical periodontal therapy and maintenance at 3‐month intervals. Plasma samples from baseline and 27.5 months following initial treatment were used to measure the concentrations of ORM, hsCRP, chemerin, and RBP4. Results At the 27.5‐month examination, ORM and hsCRP decreased noticeably in the overweight group (ORM: p = .001, hsCRP: p = .004) and normal‐weight patients (ORM: p = .007, hsCRP: p < .001). Chemerin decreased in the overweight group (p = .048), and RBP4 concentrations remained stable. Conclusion Non‐surgical periodontal therapy reduced systemically elevated inflammation‐associated biomarkers in periodontitis patients. These improvements were more pronounced in overweight patients than in normal‐weight patients.

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“…Levels of chemerin correlate positively with body mass index, blood pressure, serum LDL-cholesterol and triglycerides and negatively with serum HDL-cholesterol 99 . Because of its chemotactic effects, mediated decrease in NO production 100 and negative effects on plasma lipids, chemerin is linked to progression of atherosclerosis.…”

Section: Adiponectinmentioning

confidence: 99%