The comparative value of pleural fluid adenosine deaminase and neopterin levels in diagnostic utility of pleural tuberculosis

Koşar, Filiz; Yurt, Sibel; B, Arpınar Yiğitbaş; Seker, Basak Kusakci; H, Kutbay Özçelik; Uzun, Hafize

doi:10.5578/tt.9973

Cited by 4 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the diagnosis of LDH is less effective, the need for it to be used in conjunction with other markers is necessary. Currently, the ADA is widely used in the diagnosis of tuberculosis disease, and the ADA level in pleural effusion will not only help in the early diagnosis of tuberculous pleurisy, but also is an important indicator for differentiating tuberculosis pleural effusion and MPE . The tumor marker CEA is an important indicator of MPE as reported in previous studies …”

Section: Discussionmentioning

confidence: 69%

Clinical value of jointly detection serum lactate dehydrogenase/pleural fluid adenosine deaminase and pleural fluid carcinoembryonic antigen in the identification of malignant pleural effusion

Zhang

Wang

et al. 2016

J Clin Lab Anal

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 69%

Clinical value of jointly detection serum lactate dehydrogenase/pleural fluid adenosine deaminase and pleural fluid carcinoembryonic antigen in the identification of malignant pleural effusion

Zhang

Wang

et al. 2016

J Clin Lab Anal

View full text Add to dashboard Cite

show abstract

“…ADA activity is mainly produced by monocytes [14]; its high level in pleural effusion plays an important role in the early diagnosis of tuberculous pleurisy and its differentiation from malignant one [15].…”

Section: Discussionmentioning

confidence: 99%

The clinical utility of joined detection of cancer ratio, cancer ratio plus, Interferon gamma (IFN-ϒ) & Carcinoembryonic antigen (CEA) in differentiating lymphocytic pleural effusions

2020

View full text Add to dashboard Cite

Background: The differentiation between malignant (MPE) and tuberculous (TPE) pleural effusions should be considered in any patient with an exudative lymphocytic pleural effusion. A rapid precise diagnosis is valuable as the treatment and prognosis are totally different. The histopathological proof may shorten the time to differential diagnosis. But it may be invasive and costly. The aim of this study is to validate the clinical reliability of joined detection of cancer ratio (serum LDH to pleural ADA), cancer ratio plus (cancer ratio to percentage of pleural fluid lymphocytic count), pleural interferon gamma (pIFN-ϒ), and pleural carcinoembryonic antigen (pCEA) values to differentiate between lymphocytic pleural effusions. Results: Seventy-eight patients were included with mean age ± SD 53.09 ± 9.56 years old, 49 males and 29 females, diagnosed as 47 MPE, 24 TPE, and 7 others. Cancer ratio at cutoff value of ≥ 22 and cancer ration plus at cutoff value of ≥ 41 can discriminate MPE from any other cause with sensitivity (91.5%, 93.6%), specificity (87.5%, 91.7%), and diagnostic accuracy (90.1%, 92.9%) respectively. When the levels of pCEA and pIFN-ϒ were combined with cutoff value of cancer ratio, there were powerful diagnostic differentiating results. Conclusions: Cancer ratio and cancer ratio plus offered valid, efficient, non-invasive, and easy measuring diagnostic tools. On diagnostic uncertainty, the add-on of pCEA in cases of suspected MPE, and pIFN-ϒ in cases of suspected TPE has a trustable diagnostic efficacy with no need for further investigations.

show abstract

Elevated neopterin in tuberculosis and co-infection with HIV and the effect of treatment: A systematic review, meta-analysis, and meta-regression

Saghazadeh

Rezaei²

2022

International Immunopharmacology

View full text Add to dashboard Cite

The comparative value of pleural fluid adenosine deaminase and neopterin levels in diagnostic utility of pleural tuberculosis

Abstract: SUMMARYThe comparative value of pleural fluid adenosine deaminase and neopterin levels in diagnostic utility of pleural tuberculosis

Cited by 4 publications

References 14 publications

Clinical value of jointly detection serum lactate dehydrogenase/pleural fluid adenosine deaminase and pleural fluid carcinoembryonic antigen in the identification of malignant pleural effusion

Clinical value of jointly detection serum lactate dehydrogenase/pleural fluid adenosine deaminase and pleural fluid carcinoembryonic antigen in the identification of malignant pleural effusion

The clinical utility of joined detection of cancer ratio, cancer ratio plus, Interferon gamma (IFN-ϒ) & Carcinoembryonic antigen (CEA) in differentiating lymphocytic pleural effusions

Elevated neopterin in tuberculosis and co-infection with HIV and the effect of treatment: A systematic review, meta-analysis, and meta-regression

Contact Info

Product

Resources

About