The comparative immunotoxicity of mesoporous silica nanoparticles and colloidal silica nanoparticles in mice

Lee, So‐Young; Kim, Mi-Sun; Lee, Dakeun; Kwon, Taeg Kyu; Khang, Dongwoo; Yun, Hui-suk; Kim, Sang-Hyun

doi:10.2147/ijn.s39534

Cited by 42 publications

(15 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, mice that underwent prolonged IP administration of either AMPCol or AMP had comparable immunoglobulin levels to untreated animals. According to other studies 50 71 , these results suggest that AMPCol and AMP effect on immune system function on the parameters determined.…”

Section: Discussionsupporting

confidence: 72%

Biological and immunotoxicity evaluation of antimicrobial peptide-loaded coatings using a layer-by-layer process on titanium

Shi

Liu

Wang

et al. 2015

Sci Rep

View full text Add to dashboard Cite

The prevention and control of peri-implantitis is a challenge in dental implant surgery. Dental implants with sustained antimicrobial coating are an ideal way of preventing peri-implantitis. This study reports development of a non- immunotoxicity multilayered coating on a titanium surface that had sustained antimicrobial activity and limited early biofilm formation. In this study, the broad spectrum AMP, Tet213, was linked to collagen IV through sulfo-SMPB and has been renamed as AMPCol. The multilayer AMPCol coatings were assembled on smooth titanium surfaces using a LBL technique. Using XPS, AFM, contact angle analysis, and QCM, layer-by-layer accumulation of coating thickness was measured and increased surface wetting compared to controls was confirmed. Non-cytotoxicity to HaCaT and low erythrocyte hemolysis by the AMPCol coatings was observed. In vivo immunotoxicity assays showed IP administration of AMPCol did not effect serum immunoglobulin levels. This coating with controlled release of AMP decreased the growth of both a Gram-positive aerobe (Staphylococcus aureus) and a Gram-negative anaerobe (Porphyromonas gingivalis) up to one month. Early S. aureus biofilm formation was inhibited by the coating. The excellent long-term sustained antimicrobial activity of this multilayer coating is a potential method for preventing peri-implantitis through coated on the neck of implants before surgery.

show abstract

Section: Discussionsupporting

confidence: 72%

Biological and immunotoxicity evaluation of antimicrobial peptide-loaded coatings using a layer-by-layer process on titanium

Shi

Liu

Wang

et al. 2015

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Elevated IgG/IgM levels were also observed in the MSN treated animals. The results indicate that MSNs showed a greater extent of damage than colloidal silica NPs [ 271 ]. However, a careful study of the toxicity is needed to establish the safety of MSNs.…”

Section: Biodistribution and Biocompatibility Of Msnsmentioning

confidence: 99%

Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances

et al. 2018

View full text Add to dashboard Cite

Recent advancements in drug delivery technologies utilizing a variety of carriers have resulted in a path-breaking revolution in the approach towards diagnosis and therapy alike in the current times. Need for materials with high thermal, chemical and mechanical properties have led to the development of mesoporous silica nanoparticles (MSNs). These ordered porous materials have garnered immense attention as drug carriers owing to their distinctive features over the others. They can be synthesized using a relatively simple process, thus making it cost effective. Moreover, by controlling the parameters during the synthesis; the morphology, pore size and volume and particle size can be transformed accordingly. Over the last few years, a rapid increase in research on MSNs as drug carriers for the treatment of various diseases has been observed indicating its potential benefits in drug delivery. Their widespread application for the loading of small molecules as well as macromolecules such as proteins, siRNA and so forth, has made it a versatile carrier. In the recent times, researchers have sorted to several modifications in the framework of MSNs to explore its potential in drug resistant chemotherapy, antimicrobial therapy. In this review, we have discussed the synthesis of these multitalented nanoparticles and the factors influencing the size and morphology of this wonder carrier. The second part of this review emphasizes on the applications and the advances made in the MSNs to broaden the spectrum of its use especially in the field of biomedicine. We have also touched upon the lacunae in the thorough understanding of its interaction with a biological system which poses a major hurdle in the passage of this carrier to the clinical level. In the final part of this review, we have discussed some of the major patents filed in the field of MSNs for therapeutic purpose.

show abstract

“…Conventional MSNs can load a dose of therapeutic drug with 200-300 mg (maximally about 600 mg) drug/1 g silica. For example, conventional glucose-responsive insulin delivery systems suffer from the decrease of insulin release with repeated cycles[ 18 51 ] [ Table 3 ].…”

Section: Applications Of Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Mesoporous silica nanoparticles in target drug delivery system: A review

Bharti¹,

Nagaich²,

Pal

et al. 2015

Int J Pharma Investig

609

355

View full text Add to dashboard Cite

Due to lack of specification and solubility of drug molecules, patients have to take high doses of the drug to achieve the desired therapeutic effects for the treatment of diseases. To solve these problems, there are various drug carriers present in the pharmaceuticals, which can used to deliver therapeutic agents to the target site in the body. Mesoporous silica materials become known as a promising candidate that can overcome above problems and produce effects in a controllable and sustainable manner. In particular, mesoporous silica nanoparticles (MSNs) are widely used as a delivery reagent because silica possesses favorable chemical properties, thermal stability, and biocompatibility. The unique mesoporous structure of silica facilitates effective loading of drugs and their subsequent controlled release of the target site. The properties of mesoporous, including pore size, high drug loading, and porosity as well as the surface properties, can be altered depending on additives used to prepare MSNs. Active surface enables functionalization to changed surface properties and link therapeutic molecules. They are used as widely in the field of diagnosis, target drug delivery, bio-sensing, cellular uptake, etc., in the bio-medical field. This review aims to present the state of knowledge of silica containing mesoporous nanoparticles and specific application in various biomedical fields.

show abstract

The comparative immunotoxicity of mesoporous silica nanoparticles and colloidal silica nanoparticles in mice

Cited by 42 publications

References 39 publications

Biological and immunotoxicity evaluation of antimicrobial peptide-loaded coatings using a layer-by-layer process on titanium

Biological and immunotoxicity evaluation of antimicrobial peptide-loaded coatings using a layer-by-layer process on titanium

Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances

Mesoporous silica nanoparticles in target drug delivery system: A review

Contact Info

Product

Resources

About