Mesoporous silica nanoparticles in target drug delivery system: A review

Abstract

Due to lack of specification and solubility of drug molecules, patients have to take high doses of the drug to achieve the desired therapeutic effects for the treatment of diseases. To solve these problems, there are various drug carriers present in the pharmaceuticals, which can used to deliver therapeutic agents to the target site in the body. Mesoporous silica materials become known as a promising candidate that can overcome above problems and produce effects in a controllable and sustainable manner. In particular, mesoporous silica nanoparticles (MSNs) are widely used as a delivery reagent because silica possesses favorable chemical properties, thermal stability, and biocompatibility. The unique mesoporous structure of silica facilitates effective loading of drugs and their subsequent controlled release of the target site. The properties of mesoporous, including pore size, high drug loading, and porosity as well as the surface properties, can be altered depending on additives used to prepare MSNs. Active surface enables functionalization to changed surface properties and link therapeutic molecules. They are used as widely in the field of diagnosis, target drug delivery, bio-sensing, cellular uptake, etc., in the bio-medical field. This review aims to present the state of knowledge of silica containing mesoporous nanoparticles and specific application in various biomedical fields.

Targeted delivery of mesoporous silica nanoparticles loaded monastrol into cancer cells: an in vitro study

“…Mesoporous silica nanoparticles are considered to be very promising candidate for drug delivery specifically for water-insoluble drug. Due to large surface areas and pores, these MSNPs act as reservoirs for storing hydrophobic drugs, whereas their shape and size can be altered according to the requirements (Zhang et al 2012;Bharti et al 2015). Several drugs with low water solubility have been explored to demonstrate this concept including ibuprofen, rifampin, etc.…”

Porous Inorganic Drug Delivery Systems—a Review

“…These features allow the entrapment of drugs, proteins and other biogenic molecules and release them in a more predictable and reproducible pattern (87)(88)(89)(90). Moreover, the size of their pores can be tailored from 1.5 to several tens of nanometres allowing their matrices to encapsulate a range of molecules (87 Much work has been carried out applying synthetic mesoporous silica-based materials as controlled (90,118), targeted (106,107) and responsive (119) short two-dimensional hexagonal pore can also be characterised by direct diffusion of loaded drug into the release medium. While in three-dimensional cubic pore channels the loaded drug will require more time for the same quantity to diffuse due to longer non-linear pore channels (124).…”

Aminofunctionalized mesoporoussilica nanoparticlesloaded with 5-fluorouracil

“…Conventional MSN can load a dose of therapeuticdrug with 200 (maximally about 600 mg) drug/1 g silica [1] MSN synthesisis done mainly by two methods Sol-gel method: Four ingredients are necessary formmesoporoussilica materials: a surfactant, silica source, an acid or base catalyst and a solvent like ethanol or water. This process requires two-step consideration: Hydrolysis condensation.…”

“…They excellent chemical, Furthermore, both the can also be easily to IUPAC classification, mesoporousmaterials will 2 to 50 nm. Conventional with 200-300 mg [1] MSN synthesisis done mainly by two methods gel method: Four ingredients are necessary to formmesoporoussilica materials: a surfactant, silica source, an acid or base catalyst and a solvent like ethanol or water. This step consideration: Hydrolysis and Hydrolysis produced colloidal particles in which can be stimulated at alkaline and concentration of amphipilic surfactant ater and hydrophilic soluble precursor like polysilicic acid or silica acid.…”