The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study–6 Months Results

Protogerou, Vassilis; Beshari, Sara El; Michalopoulos, Efstathios; Mallis, Panagiotis; Chrysikos, Dimosthenis; Samolis, Αlexandros; Stavropoulos-Giokas, Catherine; Troupis, Theodoros

doi:10.3390/medicines7030014

Cited by 13 publications

(12 citation statements)

References 28 publications

(60 reference statements)

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“…Moreover, MSCs have proven their regenerative properties when applied to injured lungs, liver, kidney, and heart[ 67 ]. Recently, it is under evaluation the beneficial regenerative effect of MSCs in erectile dysfunction[ 68 , 69 ]. MSCs, due to their plasticity, have been differentiated successfully to ECs, vascular smooth muscle cells, hepatocytes, insulin-producing cells, etc .…”

Section: Origin and Properties Of Mscsmentioning

confidence: 99%

Mesenchymal stromal cells as potential immunomodulatory players in severe acute respiratory distress syndrome induced by SARS-CoV-2 infection

Mallis¹,

Michalopoulos²,

Chatzistamatiou³

et al. 2020

WJSC

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Severe acute respiratory syndrome coronavirus-2 and the related coronavirus disease-19 (COVID-19) is a worldwide emerging situation, which was initially reported in December 2019 in Wuhan, China. Currently, more than 7258842 new cases, and more than 411879 deaths have been reported globally. This new highly transmitted coronavirus is responsible for the development of severe acute respiratory distress syndrome. Due to this disorder, a great number of patients are hospitalized in the intensive care unit followed by connection to extracorporeal membrane oxygenation for breath supporting and survival. Severe acute respiratory distress syndrome is mostly accompanied by the secretion of proinflammatory cytokines, including interleukin (IL)-2, IL-6, IL-7, granulocyte colony-stimulating factor (GSCF), interferon-inducible protein 10 (IP10), monocyte chemotactic protein-1 (MCP1), macrophage inflammatory protein 1A (MIP1A), and tumor necrosis factor alpha (TNF-α), an event which is known as “cytokine storm”. Further disease pathology involves a generalized modulation of immune responses, leading to fatal multiorgan failure. Currently, no specific treatment or vaccination against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been developed. Mesenchymal stromal cells (MSCs), which are known for their immunosuppressive actions, could be applied as an alternative co-therapy in critically-ill COVID-19 patients. Specifically, MSCs can regulate the immune responses through the conversion of Th1 to Th2, activation of M2 macrophages, and modulation of dendritic cells maturation. These key immunoregulatory properties of MSCs may be exerted either by produced soluble factors or by cell-cell contact interactions. To date, several clinical trials have been registered to assess the safety, efficacy, and therapeutic potential of MSCs in COVID-19. Moreover, MSC treatment may be effective for the reversion of ground-glass opacity of damaged lungs and reduce the tissue fibrosis. Taking into account the multifunctional properties of MSCs, the proposed stem-cell-based therapy may be proven significantly effective in critically-ill COVID-19 patients. The current therapeutic strategy may improve the patient’s overall condition and in parallel may decrease the mortality rate of the current disease.

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Section: Origin and Properties Of Mscsmentioning

confidence: 99%

Mesenchymal stromal cells as potential immunomodulatory players in severe acute respiratory distress syndrome induced by SARS-CoV-2 infection

Mallis¹,

Michalopoulos²,

Chatzistamatiou³

et al. 2020

WJSC

Self Cite

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“…Clinical studies with the use of stem cells have also been published with encouraging results [ 21 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. Questions regarding the clinical use of stem cells include the type of stem cells, the method of preparation, the optimal number of stem cells and the method of administration.…”

Section: Stem Cell Therapymentioning

confidence: 99%

“…Moreover, no serious adverse effects were observed during a 12-month follow up and most of the participants recovered erectile function within six months and this effect persisted for the 12-month follow up period. In a recent novel work by our team [ 39 , 42 ], a combined technique of delivering stem cells was introduced. We administrated adipose-derived MSCs obtained after culture, resuspended in platelet lysate plasma (PLP).…”

Section: Clinical Studies: Type Of Stem Cells Preparation and Effmentioning

confidence: 99%

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Erectile Dysfunction Treatment Using Stem Cells: A Review

et al. 2021

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Erectile dysfunction (ED) is a disorder that affects the quality of life and the sexual relations of more than half of the male population aged over 40 years. The prediction regarding the incidence of ED is devastating as it is expected that this disorder will affect more than 300 million men in the next five years. Several studies have suggested the use of stem cells for the treatment of ED and showed that this type of treatment is promising in terms of damaged tissue repair as well as of clinical efficacy; however, there are several gaps in the knowledge and evidence is lacking. In order to highlight a few of them in this review, we performed a research of the literature focusing on currently available clinical studies regarding the clinical efficacy of stem cell administration for the treatment of ED. We reviewed the methods of administration, the cell types used in the performed clinical trials and the safety and efficiency of such procedures. We conclude that there are rapidly expanding and promising results from the reported clinical studies indicating that stem cells could indeed be a potential treatment for patients with ED although more studies are necessary.

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“…Patients who received ADSCs therapy demonstrated improved erectile function and maintained this for several months (maximum 12 months) without serious AEs. 10 , 18 , 55 , 56 , 57 …”

Section: Nanomedicine For Men Erectile Dysfunctionmentioning

confidence: 99%

Advances in Nanoparticle Delivery System for Erectile Dysfunction: An Updated Review

2021

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Introduction The use of current available treatment for male erectile dysfunction (ED) has some limitations that are related to efficacy and adverse effects. Nanotechnology has been used as a new tool in medicine to improve these limitations and new medications potentially to alleviate and cure ED. Aim To review the currently literature on new nano medications for ED based on scientific and clinical studies, efficacy, safety, mechanisms of action, and to identify gaps for future research. Methods A comprehensive literature review was conducted via Google Scholar, Science Direct, and PubMed on English publications using different keywords such as “erectile dysfunction”, “emerging treatments”, “nanotechnology”, and “herbal medicine”. The retrieved papers were organized into groups according to the sections covered in this review paper. Main Outcomes Measures We reviewed novel ED treatments such as nanotechnological phosphodiesterase inhibitors, papaverine hydrochloride, sialorphin, adipose tissue-derived stem cells, sonic hedgehog, and herbal medicine. Results Numerous preclinical studies have addressed novel phosphodiesterase 5 inhibitors nanoparticle, and their recent delivery systems. Nitric oxide, sialorphin, sonic hedgehog, and herbal medicine loaded nanoparticles and nano adipose tissue-derived stem cells as a potential new treatment for ED. In addition, papaverine-containing nanoparticles have been reported. A limited number of randomized clinical studies have determined the mechanism of these treatments. Conclusion A literature review on the application of nanotechnology in ED therapy was successfully conducted. New nano medications are promising to treat ED. However, further studies are warranted to further assess their efficacy and safety. Masuku NP, Unuofin JO, Lebelo SL. Advances in Nanoparticle Delivery System for Erectile Dysfunction: An Updated Review. Sex Med 2021;9:100420 .

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The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study–6 Months Results

Cited by 13 publications

References 28 publications

Mesenchymal stromal cells as potential immunomodulatory players in severe acute respiratory distress syndrome induced by SARS-CoV-2 infection

Mesenchymal stromal cells as potential immunomodulatory players in severe acute respiratory distress syndrome induced by SARS-CoV-2 infection

Erectile Dysfunction Treatment Using Stem Cells: A Review

Advances in Nanoparticle Delivery System for Erectile Dysfunction: An Updated Review

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