Advances in Nanoparticle Delivery System for Erectile Dysfunction: An Updated Review

Nanotechnology represents an expanding area of research and innovation in almost every field of science, including Medicine, where nanomaterial-based products have been developed for diagnostic and therapeutic applications. Because of their small, nanoscale size, these materials exhibit unique physical and chemical properties that differ from those of each component when considered in bulk. In Nanomedicine, there is an increasing interest in harnessing these unique properties to engineer nanocarriers for the delivery of therapeutic agents. Nano-based drug delivery platforms have many advantages over conventional drug administration routes as this technology allows for local and transdermal applications of therapeutics that can bypass the first-pass metabolism, improves drug efficacy through encapsulation of hydrophobic drugs, and allows for a sustained and controlled release of encapsulated agents. In Urology, nano-based drug delivery platforms have been extensively investigated and implemented for cancer treatment. However, there is also great potential for use of nanotechnology to treat non-oncologic urogenital diseases. We provide an update on research that is paving the way for clinical translation of nanotechnology in the areas of erectile dysfunction (ED), overactive bladder (OAB), interstitial cystitis/bladder pain syndrome (IC/BPS), and catheter-associated urinary tract infections (CAUTIs). Overall, preclinical and clinical studies have proven the utility of nanomaterials both as vehicles for transdermal and intravesical delivery of therapeutic agents and for urinary catheter formulation with antimicrobial agents to treat non-oncologic urogenital diseases. Although clinical translation will be dependent on overcoming regulatory challenges, it is inevitable before there is universal adoption of this technology to treat non-oncologic urogenital diseases.

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“…12 The application of nanotechnology to organic ED has been the subject of several recent reviews. [14][15][16][17]…”

Section: Erectile Dysfunctionmentioning

confidence: 99%

Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseases

Loloi

Babar

Davies

et al. 2022

Therapeutic Advances in Urology

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“…Infertility is defined as incompetence to attain pregnancy after a year or more of copulation without contraception. Approximately 50% of men suffer from infertility, 40-90% is attributable to oligospermia and 152 million are associated with erectile dysfunction (Abdillahi and Van Staden, 2012;Masuku et al, 2020Masuku et al, , 2021. Several factors that can interfere with fertility include exposure to various chemical compounds, drugs, chronic diseases, and lifestyle factors (Masuku et al, 2020;Kasonga et al, 2021).…”

Section: Protective Effects Against Male Infertilitymentioning

confidence: 99%

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

et al. 2021

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Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating diabetes, flatulent intestinal colic, indigestion, infertility, inflammation, insomnia, a memory booster, nausea, rheumatism, stomach ache, and urinary tract infections. To date, over 400 bioactive components, such as diarylheptanoids, gingerol analogues, phenylalkanoids, sulfonates, monoterpenoid glycosides, steroids, and terpene compounds have been derived from ginger. Increasing evidence has revealed that ginger possesses a broad range of biological activities, especially protective effects against male infertility, nausea and vomiting, analgesic, anti-diabetic, anti-inflammatory, anti-obesity, and other effects. The pharmacological activities of ginger were mainly attributed to its active phytoconstituents such as 6-gingerol, gingerdiol, gingerol, gingerdione, paradols, shogaols, sesquiterpenes, zingerone, besides other phenolics and flavonoids. In recent years, in silico molecular docking studies revealed that gingerol (6-gingerol, 8-gingerol, and 10-gingerol) and Shogaol (6-shogaol, 8-shogaol, 10-shogaol) had the best binding affinities to the receptor protein in disease conditions such as diabetes, inflammation, obesity, and SARS-CoV-2. Furthermore, some clinical trials have indicated that ginger can be consumed for alleviation of nausea and vomiting induced by surgery, pain, diabetes, obesity, inflammation, male infertility. This review provides an updated understanding of the scientific evidence on the development of ginger and its active compounds as health beneficial agents in future clinical trials.

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“…The usefulness of adipose-tissue-derived stem cells in the treatment of ED has been suggested in various in vivo studies [ 74 , 75 , 76 , 77 ]. Unfortunately, the direct correlations between adipose tissue-derived stem cells and macrophages in ED are not clear.…”

Section: Stem Cell Therapy and Macrophagesmentioning

confidence: 99%

Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease

et al. 2021

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Erectile function is regulated by complex mechanisms centered on vascular- and nerve-related systems. Hence, dysregulation of these systems leads to erectile dysfunction (ED), which causes mental distress and decreases the quality of life of patients and their partners. At the molecular level, many factors, such as fibrosis, lipid metabolism abnormalities, the immune system, and stem cells, play crucial roles in the etiology and development of ED. Although phosphodiesterase type 5 (PDE5) inhibitors are currently the standard treatment agents for patients with ED, they are effective only in a subgroup of patients. Therefore, further insight into the pathological mechanism underlying ED is needed to discuss ED treatment strategies. In this review, we focused on the biological and pathological significance of macrophages in ED because the interaction of macrophages with ED-related mechanisms have not been well explored, despite their important roles in vasculogenic and neurogenic diseases. Furthermore, we examined the pathological significance of macrophages in Peyronie’s disease (PD), a cause of ED characterized by penile deformation (visible curvature) during erection and pain. Although microinjury and the subsequent abnormal healing process of the tunica albuginea are known to be important processes in this disease, the detailed etiology and pathophysiology of PD are not fully understood. This is the first review on the pathological role of macrophages in PD.

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Advances in Nanoparticle Delivery System for Erectile Dysfunction: An Updated Review

Cited by 11 publications

References 83 publications

Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseases

Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseases

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease

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