The Combined Effects of High Energy Shock Waves and Cytostatic Drugs or Cytokines on Human Bladder Cancer Cells

Wörle, Klaus; Steinbach, Pia; Hofstädter, Ferdinand

doi:10.1016/b978-0-7506-1877-9.50160-8

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…The combination of high‐intensity ultrasound (shock waves) and generated cavitation bubbles – the same concept as that used in the US–MB method – can deliver CDDP molecules into the cells. ( 32–35 ) However, the cytotoxicity of CDDP depends on the cell type (Fig. 2); therefore, resistance to CDDP is not completely overcome simply by the application of US and MB (or cavitation bubbles).…”

Section: Discussionmentioning

confidence: 99%

Low‐intensity ultrasound and microbubbles enhance the antitumor effect of cisplatin

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Low‐intensity ultrasound and microbubbles enhance the antitumor effect of cisplatin

et al. 2008

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“…It may also be part of the explanation why cytotoxic drugs have enhanced effects when combined with SW treatment. 34 …”

Section: Discussionmentioning

confidence: 99%

Proinflammatory Reaction and Cytoskeletal Alterations in Endothelial Cells after Shock Wave Exposure

Sondén

Johansson²,

Palmblad³

et al. 2006

Journal of Investigative Medicine

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“…A number of studies have shown that high-energy shock waves are cytotoxic to tumour cells [8], enhance drug efficiency [9] and have chemotherapeutic effects in gene therapy and anticancer drug delivery [10,11]. However, the detailed mechanism of cell permeabilization due to a shock wave still remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Molecular dynamics study of the interaction of a shock wave with a biological membrane

Lechuga

Drikakis

Pal

2007

Numerical Methods in Fluids

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SUMMARYThis paper presents a computational study of the interaction of a shock wave with a biological membrane. The membrane model comprises 21 555 atoms which build 66 dalmitoyloleoylphosphatidylcholine (POPC) lipids forming the bilayer, and 4237 water molecules, with the distance between the layers being set to fit around the actual membrane thickness (54Å), and the lattice period being set to fit the actual surface density of lipid molecules. We have employed a molecular dynamics method for solving the Newton equations of motion numerically thereby providing a strategy to understand the basic physics of the biological structure at atomistic level. A shock wave has been modelled as an impulse of 40 Pa s, and simulations for the interaction of the shock wave with the membrane have been performed for 200 ps to investigate the different effects of the shock wave on different membrane properties including thickness, area, volume, order parameter and lateral diffusion.

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The Combined Effects of High Energy Shock Waves and Cytostatic Drugs or Cytokines on Human Bladder Cancer Cells

Cited by 4 publications

References 27 publications

Low‐intensity ultrasound and microbubbles enhance the antitumor effect of cisplatin

Low‐intensity ultrasound and microbubbles enhance the antitumor effect of cisplatin

Proinflammatory Reaction and Cytoskeletal Alterations in Endothelial Cells after Shock Wave Exposure

Molecular dynamics study of the interaction of a shock wave with a biological membrane

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