The Combined Effect of Hyperuricaemia and Overweight/Obesity on Risk of Hypertension in Adults

Abstract

Background: While hyperuricaemia and overweight/obesity can act alone to increase the prevalence of hypertension, few studies have examined their combined effect. Methods: This cross-sectional study of 42 332 Han Chinese from southwestern China investigated the combined effect of hyperuricaemia and overweight/obesity on risk of hypertension in the entire sample as well as in different genders and age groups. Results: Hypertension was significantly more prevalent among individuals with both hyperuricaemia and overweight/obesity (45.5%) than among those with hyperuricaemia alone (28.1%) or overweight/obesity alone (31.3%). Similarly, the increase in hypertension risk in the presence of both hyperuricaemia and overweight/obesity (OR = 6.777, 95%CI 6.133, 7.489) was significantly greater than the increase in the presence of hyperuricaemia alone (OR = 3.168, 95%CI 2.705, 3.711) or overweight/obesity alone (OR = 3.693, 95% CI 3.503, 3.893). These results were similar across each age group. The same trend was also observed when comparing men and women, though the odds ratios were greater for women. Conclusion: Co-occurrence of hyperuricaemia and overweight/obesity increases risk of hypertension more than either morbidity on its own, and this risk differential is significantly greater in women than men. These findings should be confirmed in other ethnic groups and in longitudinal studies.

Therapeutic effects of chitin from Pleurotus eryngii on high-fat diet induced obesity in rats

“…Obesity is a type of systemic metabolic disease, not only causing changes in body shape, but also adding significant physical load and contributing to development and pathogenesis of many diseases (Huang et al, 2017). The deposition of a large amount of adipose tissue in organs, blood vessels, and other parts of the body, which can negatively affect cardio-cerebrovascular, hepatobiliary digestive, and respiratory system function, leading to hyperlipidemia, hypertension, diabetes, atherosclerosis, myocardial infarction, and other diseases (Gando et al, 2018;He et al, 2015;Li et al, 2016;Zhang et al, 2016). Lipoprotein levels are also disturbed or complicated with lipid metabolism disorders, accompanied by a reduction in HDL levels and an increase in total cholesterol (TC), triglyceride (TG) and LDL levels, which enter the liver and support fat synthesis, in turn causing development of fatty liver and abnormal liver function and elevated levels of associated liver transaminases (such as ALT, AST) (Han et al, 1999;Jahn et al, 2019;Merli et al, 2019).…”

Gambaran Kadar Asam Urat Serum pada Mahasiswa dengan Indeks Massa Tubuh ≥23 kg/m2 di Fakultas Kedokteran Universitas Sam Ratulangi

“…9 Hasil penelitian ini didukung penelitian sebelumnya yang menemukan kaitan antara hiperurisemia dengan peningkatan berat badan. Studi cross sectional yang dilakukan Li et al 10 pada individu overweight dan obesitas di China menemukan 1862 responden (10,5%) mengalami hiperurisemia. Studi tersebut menjelaskan bahwa jaringan adiposa viseral pada individu overweight dan obese melepaskan asam lemak bebas ke dalam sirkulasi yang meningkatkan glukoneogenesis di hepar yang kemudian menurunkan uptake glukosa oleh jaringan perifer dan mengakibatkan hiperinsulinemia.…”

“…Penelitian tersebut mendapatkan bahwa individu dengan IMT di atas normal (overweight dan obesitas) lebih memungkinkan untuk terjadinya hiperurisemia daripada individu yang memiliki IMT normal. 10 Penelitian Ewenighi et al 11 pada pria dewasa yang sehat di Nigeria, melalui analisis korelasi Pearson menemukan hubungan yang bermakna antara peningkatan IMT dan hiperurisemia. Keadaan ini terjadi akibat akumulasi lemak pada individu yang memiliki indeks massa tubuh diatas normal.…”