The combined effect of dietary supplement “Leptin Manager” and power fitness exercises on weight loss in women with different LEPR (rs1137101) genotypes

Abstract

The aim of this study was to establish the effect of combined action of the dietary supplement "Leptin Manager™" and the power fitness program on weight loss in women with different genotypes of the 1 st and the 2 nd period of mature age. The study involved 62 overweight women (BMI≥25).The experimental group consisted of 21 women, who participated in the power fitness training program while simultaneously administering the drug "Leptin Manager" (manufactured by Xymogen, USA). The control group consisted of 17 women, who were engaged in power fitness and did not take the drug, and 24 women, who were not engaged in power fitness. The duration of the study was three months. The training method was based on the CrossFit system, functional training, included using machines (block and lever devices) according to the Full-body system in each training. The Q223R polymorphism of the leptin receptor gene (LEPR) was determined by the polymerase chain reaction in real time. Leptin indicators in Q allele carriers were twice higher than in R/R-genotype carriers (p = 0.045). Combined effect of the training program of power fitness and the use of the drug "Leptin Manager" resulted in more significant changes of anthropometric indices of the body composition of overweight women when compared with the control group. The most drastic changes in the body composition occurred in women with the R/R genotype of the LEPR gene. The usage of the drug "Leptin Manager" reduced leptin levels: in the experimental group by 33.4% (p < 0.05), meanwhile in the control group by 6.1%.Conclusion. The Q223R polymorphism of the LEPR gene can be a molecular genetic marker of leptin resistance. Q allele Q223R polymorphism of the LEPR gene facilitates the development of obesity. R alleles and the R/R-genotype of the LEPR gene help reducing leptin levels after exercise. The usage of "Leptin Manager" combined with physical activity reliably decreases leptin levels when compared with the control group.