The combinatory effects of combined training (endurance–resistance) and garlic supplementation on oxidative stress and antioxidant adaptations in untrained boys

Khoobkhahi, Nazanin; Delavar, Reza; Nayebifar, Shila

doi:10.1016/j.scispo.2019.05.007

Cited by 7 publications

(18 citation statements)

References 16 publications

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“…Alami‐Harandi et al reported that supplementation of 400 mg/d garlic in pregnant women at risk for pre‐eclampsia led to a significant increase in plasma glutathione (GSH); however, did not affect TAC 28 . Another trial study showed that 250 mg/d garlic supplementation for 8 weeks decreased serum levels of MDA and increased TAC 29 …”

Section: Discussionmentioning

confidence: 99%

A randomized, double‐blind, placebo‐controlled clinical trial, evaluating the garlic supplement effects on some serum biomarkers of oxidative stress, and quality of life in women with rheumatoid arthritis

2020

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Aim Rheumatoid arthritis (RA), is a prevalent immune‐inflammatory disease, which is associated with disabling pain. Oxidative stress might play a role in RA pathogenesis and outcomes. According to the antioxidant properties of garlic, the current study was performed to evaluate the garlic supplement effects on some serum levels of oxidative stress biomarkers, and quality of life in patients with rheumatoid arthritis. Methods Seventy women with RA participated in this randomized, double‐blind, placebo‐controlled, parallel‐design trial. The patients were randomly divided into two groups, receiving two tablets of either 500 mg garlic or placebo daily for 8 weeks. Serum levels of total antioxidant capacity (TAC) and malondialdehyde (MDA) and quality of life were determined at baseline and end of week 8. A health assessment questionnaire (HAQ) was used to evaluate the quality of life related to health. Results Of 70 patients enrolled in the trial, 62 subjects were included in the final analysis. At the end of the study, there was a significant increase in serum levels of TAC in the garlic group as compared with the placebo group (26.58 ± 77.30 nmol of Trolox equivalent/ml vs 16.11 ± 0.92 nmol of Trolox equivalent/mL; P = .026). In addition, MDA levels were significantly decreased in the intervention group compared with the control group (−0.82 ± 1.99 nmol/mL vs 0.36 ± 2.57 nmol/mL; P = .032). Pain after activity and HAQ scores decreased in the garlic group compared with the placebo (−11.96 ± 13.43 mm vs −0.06 ± 13.41 mm; P < .001, 0.17 ± 20 vs 0.05 ± 0.15; P < .001, respectively). Conclusions The findings suggest that garlic supplementation for 8 weeks resulted in significant improvements in oxidative stress, HAQ in women with RA.

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Section: Discussionmentioning

confidence: 99%

A randomized, double‐blind, placebo‐controlled clinical trial, evaluating the garlic supplement effects on some serum biomarkers of oxidative stress, and quality of life in women with rheumatoid arthritis

2020

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“…Recent meta-analysis of clinical trials demonstrated that garlic supplementation modulates oxidative stress markers, including total antioxidant capacity (TAC) and malondialdehyde (MDA) [ 35 ]; for example, the garlic tablet (Garlet) exerted a significant role on oxidative stress via decreasing MDA levels and improving TAC concentration in postmenopausal osteoporotic women at a dose of 1200 μg allicin daily for one month compared with placebo [ 36 ]. Furthermore, garlic administration synergistically improved (resistance and endurance) the training effect against oxidative stress by modulating oxidative stress markers, such as TAC and MDA, after eight weeks of treatment at a dose of 250 mg garlic capsule per day for eight weeks [ 37 ]. However, another double-blind crossover pilot study conducted on type 2 diabetic patients revealed that AGE has no significant effect at 1200 mg per day on the oxidative stress in endothelial tissue after four weeks treatment [ 38 ].…”

Section: Clinical Trials On Garlicmentioning

confidence: 99%

“…Moreover, the combination of antidiabetic drug metformin at 500 mg two times per day with garlic at 300 mg three times per day for 24 weeks had more potential in the management of patients with diabetes by reducing total cholesterol, LDL, and TG and improving hyperlipidemia [ 114 ]. On the other hand, a double-blind, placebo-controlled crossover pilot study showed that AGE had no significant effect on insulin resistance at 1200 mg per day for four weeks in adults with type 2 diabetes [ 37 ]. Finally, a double-blind clinical trial in diabetic patients revealed that herbal medicine containing garlic at a dose of 750 mg 3 times per day for 12 weeks had potential effects for diabetes management by reducing fasting glucose blood levels through the decrease of HbA1 [ 115 ].…”

Section: Clinical Trials On Garlicmentioning

confidence: 99%

Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview

et al. 2020

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Garlic is a polyphenolic and organosulfur enriched nutraceutical spice consumed since ancient times. Garlic and its secondary metabolites have shown excellent health-promoting and disease-preventing effects on many human common diseases, such as cancer, cardiovascular and metabolic disorders, blood pressure, and diabetes, through its antioxidant, anti-inflammatory, and lipid-lowering properties, as demonstrated in several in vitro, in vivo, and clinical studies. The present review aims to provide a comprehensive overview on the consumption of garlic, garlic preparation, garlic extract, and garlic extract-derived bioactive constituents on oxidative stress, inflammation, cancer, cardiovascular and metabolic disorders, skin, bone, and other common diseases. Among the 83 human interventional trials considered, the consumption of garlic has been reported to modulate multiple biomarkers of different diseases; in addition, its combination with drugs or other food matrices has been shown to be safe and to prolong their therapeutic effects. The rapid metabolism and poor bioavailability that have limited the therapeutic use of garlic in the last years are also discussed.

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“…Reactive species can react with most biological macromolecules, resulting in their oxidative modification; this results in the loss of their function [ 36 ]. In addition, reactive species are responsible for inducing an increase in the levels of inflammatory mediators at the injury site, where they activate glial cells, which are responsible for amplifying the inflammatory process by synthesizing and releasing pro inflammatory mediators, thereby promoting a pro inflammatory cascade [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Resistance Training and Bowdichia virgilioides Hydroethanolic Extract on Oxidative Stress Markers in Rats Submitted to Peripheral Nerve Injury

et al. 2020

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The objective of this study was to analyze the effects of the combination of resistance training (RT) and the hydroethanolic extract (EHE) of Bowdichia virgilioides as markers of oxidative stress (OS) in rats with peripheral nerve injury (PNI). Rats were allocated into six groups (n = 10): animals without interventions (C), animals with an exposed nerve but without injury, injured animals, trained and injured animals, injured animals that received EHE, and animals that received a combination of RT and EHE. RT comprised the climbing of stairs. EHE was orally administered (200 mg/kg) for 21 days after PNI induction. RT reduced the amount of lipoperoxidation in plasma (14.11%). EHE reduced lipoperoxidation in the plasma (20.72%) and the brain (41.36). RT associated with the extract simultaneously reduced lipoperoxidation in the plasma (34.23%), muscle (25.13%), and brain (43.98%). There was an increase in total sulhydrilyl levels (a) in the brain (33.33%) via RT; (b) in the brain (44.44%) and muscle (44.51%) using EHE; and (c) in the plasma (54.02%), brain (54.25%), and muscle using the combination of RT + EHE. These results suggest that RT associated with oral EHE results in a decrease in OS.

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The combinatory effects of combined training (endurance–resistance) and garlic supplementation on oxidative stress and antioxidant adaptations in untrained boys

Cited by 7 publications

References 16 publications

A randomized, double‐blind, placebo‐controlled clinical trial, evaluating the garlic supplement effects on some serum biomarkers of oxidative stress, and quality of life in women with rheumatoid arthritis

A randomized, double‐blind, placebo‐controlled clinical trial, evaluating the garlic supplement effects on some serum biomarkers of oxidative stress, and quality of life in women with rheumatoid arthritis

Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview

Effects of Resistance Training and Bowdichia virgilioides Hydroethanolic Extract on Oxidative Stress Markers in Rats Submitted to Peripheral Nerve Injury

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