The combination of single-dose montelukast and loratadine on exercise-induced bronchospasm in children

Abstract

The aim of the study was to evaluate the protective effect of single-dose, combination treatment comprising montelukast (5 mg) and loratadine (10 mg), on exercise-induced bronchoconstriction in asthmatic children. The combination was compared to placebo, loratadine and montelukast alone.Nineteen children were enrolled in a double-blind randomised, single-dose, crossover study. For each treatment patients undertook two treadmill exercise tests, 2 and 12 h respectively after single-dose administration.No significant differences were seen in the maximum fall in forced expiratory volume in one second (FEV1) 2 h after treatment and placebo. Whereas significant differences in maximum fall in FEV1 were observed between treatment groups 12 h after administration. Loratadine alone did not show any significant protection or any additional effect in comparison with montelukast alone. Single doses of montelukast and montelukast plus loratadine were significantly more effective than loratadine at 12 h.The present study, performed using single-dose treatments, demonstrated that maximal protective effect by montelukast was obtained 12 h after dosing and that montelukast plus loratadine did not result in significant additive bronchoprotective effects on exercise-induced bronchoconstriction.

Effect of Desloratadine on Patients with Allergic Rhinitis and Exercise-Induced Bronchoconstriction: A Placebo Controlled Study

“…Options available to treat their EIB include the use of ß 2 agonist or montelukast (9). Although our study did not demonstrate a dramatically beneficial effect, there is some evidence from our data that an anti-histamine used to treat the symptoms of allergic rhinitis may also have some effect on attenuating EIB.…”

Actualización De La Prueba De Provocación Bronquial Con Ejercicio (Ppbe)

“…Con respecto a la suspensión de antihistamínicos, también se deja a criterio del médico tratante. Se sugiere suspender 72 horas antes del examen, sin embargo se ha visto que loratadina, cetirizina, fexofenadina no afectan los resultados del estudio (12)(13)(14). El consumo de cafeína disminuye la reactividad bronquial por ejercicio por lo cual el paciente no debe ingerir este producto al menos 24 horas previo al examen.…”

Chapter 5 Histamine in Asthmatic and Fibrotic Lung Disorders

“…While the protective effects of leukotriene receptor antagonists have been extensively documented in bronchoconstriction induced by exercise (Manning et al, 1990;Leff et al, 1998;Dahlén et al, 2002) or aspirin in AIA (Christie et al, 1991;Dahlén et al, 1993), the response to cumulative challenge with mannitol was found to be inhibited only with respect to the recovery phase, not the sensitivity to this cumulative challenge (Brannan et al, 2001). For bronchoconstriction induced by exercise, however, the protective effect of a single intervention with antihistamines appears to have minimal effects both in children and adults (Dahlén et al, 2002;Peroni et al, 2002). There is also substantial release of PGD 2 after exercise (O'Sullivan et al, 1998b) and mannitol challenges (Brannan et al, 2003) and that TP receptor antagonists, which block bronchoconstriction to PGD 2 , demonstrate protective effects on the airway response to exercise challenge (Magnussen et al, 1992), which highlights the importance of this major mast cell mediator in the asthmatic responses.…”