The combination of pretreatment prognostic nutritional index and neuron‐specific enolase enhances prognosis predicting value of small cell lung cancer

Wang, Chunyan; Shi, Jin; Xu, Shanqi; Cao, Shoubo

doi:10.1111/crj.13291

Cited by 10 publications

(6 citation statements)

References 33 publications

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“…Notably, CEA, CA724, CA125, CA199, and AFP are often highly correlated with digestive system tumors and have a weak role in lung cancer. NSE is the preferred marker for detecting SCLC ( 30 , 31 ) and was also found to be weakly associated with NSCLC in this study. Cytokeratin 211 and squamous cell carcinoma antigen are considered the most valuable serum markers for NSCLC.…”

Section: Discussionsupporting

confidence: 53%

Value of dual-layer spectral detector CT in predicting lymph node metastasis of non-small cell lung cancer

Xie,

Yan,

Liu

et al. 2024

Quant Imaging Med Surg

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Background The accurate assessment of lymph node metastasis (LNM) is crucial for the staging, treatment, and prognosis of lung cancer. In this study, we explored the potential value of dual-layer spectral detector computed tomography (SDCT) quantitative parameters in the prediction of LNM in non-small cell lung cancer (NSCLC). Methods In total, 91 patients presenting with solid solitary pulmonary nodules (8 mm < diameter ≤30 mm) with pathologically confirmed NSCLC (57 without LNM, and 34 with LNM) were enrolled in the study. The patients’ basic clinical data and the SDCT morphological features were analyzed using the chi-square test or Fisher’s exact test. The Mann-Whitney U -test and independent sample t -test were used to analyze the differences in multiple SDCT quantitative parameters between the non-LNM and LNM groups. The diagnostic efficacy of the corresponding parameters in predicting LNM in NSCLC was evaluated by plotting the receiver operating characteristic (ROC) curves. A multivariate logistic regression analysis was conducted to determine the independent predictive factors of LNM in NSCLC. Interobserver agreement was assessed using intraclass correlation coefficients (ICCs) and Bland-Altman plots. Results There were no significant differences between the non-LNM and LNM groups in terms of age, sex, and smoking history. Lesion size and vascular convergence sign differed significantly between the two groups (P<0.05), but there were no significant differences in the six tumor markers. The SDCT quantitative parameters [SAR 40keV , SAR 70keV , Δ 40keV , Δ 70keV , CER 40keV , CER 70keV , NEF 40keV , NEF 70keV , λ, normalized iodine concentration (NIC) and NZ eff ] were significantly higher in the non-LNM group than the LNM group (P<0.05). The ROC analysis showed that CER 40keV , NIC, and CER 70keV had higher diagnostic efficacy than other quantitative parameters in predicting LNM [areas under the curve (AUCs) =0.794, 0.791, and 0.783, respectively]. The multivariate logistic regression analysis showed that size, λ, and NIC were independent predictive factors of LNM. The combination of size, λ, and NIC had the highest diagnostic efficacy (AUC =0.892). The interobserver repeatability of the SDCT quantitative and derived quantitative parameters in the study was good (ICC: 0.801–0.935). Conclusions The SDCT quantitative parameters combined with the clinical data have potential value in predicting LNM in NSCLC. The size + λ + NIC combined parameter model could further improve the prediction efficacy of LNM.

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Section: Discussionsupporting

confidence: 53%

Value of dual-layer spectral detector CT in predicting lymph node metastasis of non-small cell lung cancer

Xie,

Yan,

Liu

et al. 2024

Quant Imaging Med Surg

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“…Furthermore, a study of 301 cases of small cell lung cancer (163 limited-stage cases, 54.2%; 138 extensive-stage cases, 45.8%) found that nutritional status before treatment initiation and NSE level (15 ng/mL) were prognostic factors, in addition to the treatment strategy (localized-stage or extensive-stage chest irradiation). A previous study reported that patients with NSE > 15 ng/mL had a poor prognosis (Wang et al 2021 ). A systematic review of 18 studies and 2981 cases reported that NSE is a predictor of overall survival and progression-free survival (Tian et al 2020 ).…”

Section: Discussionmentioning

confidence: 98%

Association between PET–CT accumulation in the hypothalamic/pituitary regions and neuron-specific enolase/primary tumor in limited-stage small cell lung cancer: a case-controlled retrospective study

Okada,

Zama,

Itonaga

et al. 2024

EJNMMI Rep.

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Background Research on the relationship between neuron-specific enolase (NSE) levels and normal organs, particularly the central nervous system, in small cell lung cancer is limited. Therefore, this study aimed to investigate the relationship between positron emission tomography–computed tomography (PET–CT) accumulation at hypothalamic/pituitary regions, tumor activity, and NSE level in limited-stage small cell lung cancer. We retrospectively analyzed patients who were diagnosed with limited-stage small cell lung cancer at Tokyo Medical University Hospital between July 1, 2019, and May 31, 2023, and were treated with chemoradiotherapy or radiotherapy. Leukocytes, erythrocytes, hemoglobin, platelets, total protein, albumin, NSE, and carcinoembryonic antigen were measured in blood samples obtained before treatment initiation. The maximum standardized uptake value (SUVmax), volume, and total lesion glycolysis (TLG) of each hypothalamic /pituitary region, primary tumor, and lymph node metastases were extracted from PET–CT images. The total tumor volume (primary tumor volume plus lymph node metastases volume) and total TLG (primary tumor TLG plus lymph node metastases TLG) were calculated. Results This study included 19 patients (mean age, 70.1 ± 8.8 years; 13 men and 6 women); the pathology in all patients was small cell lung cancer. Patients were classified into two groups according to the NSE reference value (16.3 ng/mL): six patients having NSE level below the reference value and 13 having NSE level above the reference value. The SUVmax in the hypothalamic/pituitary region was 2.95 in the NSE < 16.3 ng/mL group and 4.10 in the NSE > 16.3 ng/mL group, with a statistically significant difference (p = 0.03). The total tumor volume was 17.8 mL in the NSE < 16.3 ng/mL group and 98.9 mL in the NSE > 16.3 ng/mL group, with a statistically significant difference (p < 0.01). A correlation coefficient of r = 0.458 (p = 0.0486) was observed between SUVmax in the hypothalamus/pituitary and NSE level. A correlation coefficient of r = 0.647 (p < 0.01) was also observed between total tumor volume and NSE level. Finally, a correlation coefficient of r = 0.53 (p = 0.01) was observed between hypothalamic/pituitary TLG and primary tumor TLG. Conclusions The findings demonstrated a correlation between hypothalamic/pituitary activity and tumor activity, suggesting the prognostic significance of NSE.

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“…In our case, LDH, NSE, and pro-GRP levels in the blood were simultaneously elevated, but these three markers are useful in the diagnosis and prognosis of SCLC. 6–8 Under microscopy, the tumor cells were small and deeply stained with extrusion deformation, which should be distinguished from some small round cell tumors in the lungs. (1) First, the serological data, microscopic morphology, and immunohistochemical results of neuroendocrine markers easily results in a misdiagnosis of SCLC because it is more common than RMS in the lungs.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological features and prognosis of primary pulmonary rhabdomyosarcoma in middle-aged and elderly patients: a case report and literature review

Jin¹,

Guihua²,

Jiatai³

et al. 2023

J Int Med Res

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To date, only 34 cases of primary pulmonary rhabdomyosarcoma (PPRMS) in the middle-aged and elderly population have been published. However, analyses of the clinicopathological characteristics and prognosis of PPRMS in this population have not been performed. A 75-year-old man visited our hospital because of abdominal pain and discomfort. His serum lactate dehydrogenase, neuron specific enolase, and progastrin-releasing peptide levels were elevated. Positron emission tomography–computed tomography revealed a lobulated mass of 7.6 × 5.5 cm2 in the lower lobe of the left lung with abnormally high fluoro-2-deoxy-d-glucose metabolism. Histologically, the tumor cells were small with little cytoplasm, deep nuclear staining, and heavily stained nuclear chromatin. Immunohistochemically, the tumor cells were positive for desmin, MyoD1 myogenin, synaptophysin, and CD56. Cytogenetic analysis for FOXO1A translocation was negative. Finally, the patient was diagnosed with PPRMS. He received combined chemotherapy with vincristine 1 mg, actinomycin 0.4 mg, cyclophosphamide 0.8 mg; however, only one course of chemotherapy was completed, and the patient died 2 months after diagnosis. PPRMS in middle-aged and elderly people is a highly malignant soft tissue tumor with significant clinicopathological characteristics.

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The combination of pretreatment prognostic nutritional index and neuron‐specific enolase enhances prognosis predicting value of small cell lung cancer

Cited by 10 publications

References 33 publications

Value of dual-layer spectral detector CT in predicting lymph node metastasis of non-small cell lung cancer

Value of dual-layer spectral detector CT in predicting lymph node metastasis of non-small cell lung cancer

Association between PET–CT accumulation in the hypothalamic/pituitary regions and neuron-specific enolase/primary tumor in limited-stage small cell lung cancer: a case-controlled retrospective study

Clinicopathological features and prognosis of primary pulmonary rhabdomyosarcoma in middle-aged and elderly patients: a case report and literature review

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