To date, only 34 cases of primary pulmonary rhabdomyosarcoma (PPRMS) in the middle-aged and elderly population have been published. However, analyses of the clinicopathological characteristics and prognosis of PPRMS in this population have not been performed. A 75-year-old man visited our hospital because of abdominal pain and discomfort. His serum lactate dehydrogenase, neuron specific enolase, and progastrin-releasing peptide levels were elevated. Positron emission tomography–computed tomography revealed a lobulated mass of 7.6 × 5.5 cm2 in the lower lobe of the left lung with abnormally high fluoro-2-deoxy-d-glucose metabolism. Histologically, the tumor cells were small with little cytoplasm, deep nuclear staining, and heavily stained nuclear chromatin. Immunohistochemically, the tumor cells were positive for desmin, MyoD1 myogenin, synaptophysin, and CD56. Cytogenetic analysis for FOXO1A translocation was negative. Finally, the patient was diagnosed with PPRMS. He received combined chemotherapy with vincristine 1 mg, actinomycin 0.4 mg, cyclophosphamide 0.8 mg; however, only one course of chemotherapy was completed, and the patient died 2 months after diagnosis. PPRMS in middle-aged and elderly people is a highly malignant soft tissue tumor with significant clinicopathological characteristics.
Background: Primary pulmonary rhabdomyosarcoma(PPRMS)in the middle-aged and elderly is a very rare event with only a few cases published. To date, only thirty-five cases of PPRMS in the middle-aged and elderly have been published. However, the analyses on clinicopathological characteristics and prognosis of PPRMS in the middle-aged and elderly have not been performed.Case presentation: We report an additional case of PPRMS in the middle-aged and elderly.Conclusions: PPRMS in the middle-aged and elderly was a highly malignant soft tissue tumor with obvious gender characteristics and significant age distribution. Pleomorphic rhabdomyosarcoma (RMS) was the most common subtype, with poor prognosis and significantly prolonged survival time after surgical resection.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.