The Colonic Microbiome and Epithelial Transcriptome Are Altered in Rats Fed a High-Protein Diet Compared with a Normal-Protein Diet

Abstract

Our findings suggest that the HPD altered the colonic microbial community, shifted the metabolic profile, and affected the host response in the colons of rats toward an increased risk of colonic disease.

Structure of protein emulsion in food impacts intestinal microbiota, caecal luminal content composition and distal intestine characteristics in rats

“…Such an increase in Lactobacillus and lower abundance of Bifidobacteria was found consistently in the ileum and in the cecum. Interestingly, high‐protein diet in humans, pigs and rats also decreased Bifidobacteria and/or increased Lactobacillus abundances . Therefore, LFE diet seems to replicate some of the effects of high‐protein diets, which are related to a greater peptides supply in the distal part of the gut.…”

Paneth cell defects in Crohn’s disease patients promote dysbiosis

“…Of note, the microbiota has been proposed to play an important role in regulating host energy homeostasis through oxidative phosphorylation (49). Furthermore, a recent mouse study showed that alterations in diet can alter colonic microbial composition as well as downregulation of oxidative phosphorylation genes (50). Further investigation is needed to reveal the mechanistic insight between Paneth cell function, microbiota changes, and oxidative phosphorylation status in the context of CD.…”

Dietary Protein and Amino Acid Supplementation in Inflammatory Bowel Disease Course: What Impact on the Colonic Mucosa?

“…Several animal studies showed that a modification of the protein intake alters the composition of the gut microbiota despite important variations, according to the experimental design. Interestingly, two studies performed with rats receiving an HP diet reported a significant decrease in the abundance of Faecalibacterium prausnitzii in the large intestine [22,23]. This commensal bacterium has demonstrated anti-inflammatory properties in vivo using a mouse colitis model.…”