The Collecting Duct Carcinoma of the Kidney: A Cytogenetical Study

Antonelli, Alessandro; Portesi, E.; Cozzoli, A.; Zanotelli, Tiziano; Tardanico, Regina; Balzarini, Piera; Grigolato, Pier Giovanni; Cunico, S. Cosciani

doi:10.1016/s0302-2838(03)00152-0

Cited by 41 publications

(25 citation statements)

References 16 publications

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“…The results demonstrated that the occurrence of BDC is 0.64%, which is similar to other cases of BDC reported in Mexico, Japan and Italy (5,7,8). The present two cases, which presented with different grades and prognoses of BDC, were in stark contrast.…”

Section: Discussionsupporting

confidence: 86%

Bellini's duct carcinoma: A report of two cases and a review of the literature

Jin

Lü

et al. 2016

Oncology Letters

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Abstract. Bellini's duct carcinoma (BDC) is a rare and aggressive variant of renal cell carcinoma that possesses an extremely poor prognosis. The greater the grade or stage of disease, the poorer the prognosis tends to be. This study presents two cases of BDC; one case of low grade BDC and one case of high grade BDC in a 47-year-old male and 74-year-old female, respectively. The 47-year-old male patient presented with painless gross hematuria, which had lasted for 3 weeks and subsequently underwent purely laparoscopic nephroureterectomy. After 4-years of follow-up, the patient remained disease-free. By contrast, a right renal tumor was identified in the 74-year-old female patient during a routine examination. Radical right nephrectomy and lymph node dissection were performed, however, 10 months after surgery the patient succumbed due to wide-spread metastasis. The two cases reported in the present study not only represent excellent examples of the disease spectrum, but also act as a reminder of the possibility of detecting BDC in an early stage of disease. Therefore, the epidemiology of BDC has been discussed, and the aggressive growth pattern of BDC has been presented in terms of signs, symptoms and imaging examinations, including ultrasonography, computed tomography (CT), angiography and single photon emission CT, in the early stage of disease. IntroductionBellini's duct carcinoma (BDC), which arises from the distal segment of the collecting duct, is a rare and aggressive malignant tumor with a poor prognosis. BDC comprises <1% of all renal tumors (1), but it is extremely aggressive and is accompanied by metastatic diseases in the majority of reported cases. The prognosis of BDC is poor, with ~70% patients succumbing due to disease progression within 2 years of diagnosis (2). The only favorable prognosis factor is low-grade and low-stage disease (3-5). If BDC could be detected in the early stage of disease, the poor prognosis of BDC may be changed. However, due to the rarity of BDC, the similarities of the symptoms, signs and imaging examination findings with other variants of renal cell carcinoma (RCC), and the poor prognosis of BDC, it is challenging and crucial to differentiate other RCC variants from BDC. The RCC database of Peking University Shenzhen Hospital (Shenzen, China) was reviewed, and out of a total of 311 RCC cases, two cases of BDC with different grades of disease and prognoses were identified. Case reportCase one. In December 2010, a 47-year-old man presented to the Department of Urology, Peking University Shenzhen Hospital, with a complaint of painless gross hematuria during urination that had lasted 3 weeks. Physical examination revealed percussion pain over the left kidney region. The laboratory examinations revealed no extrarenal manifestations. The blood routine examination revealed no anemia and polycythemia; electrolyte examination revealed no hypercalcemia; erythrocyte sedimentation rate (ESR) examination revealed no fast ESR; and alkaline phosphatase examination revealed no elevated a...

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Section: Discussionsupporting

confidence: 86%

Bellini's duct carcinoma: A report of two cases and a review of the literature

Jin

Lü

et al. 2016

Oncology Letters

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“…Con un elevado riesgo (72,7%), de presentarse como enfermedad localmente avanzada y con una probabilidad del 66% de presentar metástasis ganglionares en pacientes tratados mediante nefrectomía radical 8 . Sin embargo, en 1997, Maclennan et al 9 describieron 13 casos similares al nuestro, para los que propusieron el nombre de carcinoma de conductos colectores de bajo grado.…”

Section: Discussionunclassified

“…Se han documentado varias alteraciones citogenéticas asociadas al CRCC, siendo la hipoploidia y las alteraciones numéricas o estructurales del cromosoma 1 y de los autosomas las más frecuentemente observadas 8 .…”

Section: Discussionunclassified

Carcinoma renal de los conductos colectores de bajo grado en un paciente en tratamiento con hemodiálisis

Martín

Olmedo

García-Ripoll

et al. 2008

Actas Urológicas Españolas

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pacientes en tratamiento con diálisis por enfermedad renal en estadio terminal tienen un riesgo aumentado de padecer varios tipos de cáncer, especialmente de riñón y del tracto urinario.Presentamos el caso de un varón de 56 años en tratamiento con hemodiálisis. En una ecografía de control se apreció una imagen compatible con un quiste complicado de unos dos centímetros a nivel del polo inferior de riñón izquierdo, que es confirmada mediante TC y RM abdominal.Se practicó una nefrectomía izquierda por vía laparoscópica. El diagnóstico histológico fue de carcinoma renal de los conductos colectores de bajo grado, una variante infrecuente de tumor renal.Palabras Clave: Carcinoma de los conductos colectores. Bajo grado. Diálisis. ABSTRACT LOW-GRADE COLLECTING DUCT CARCINOMA OF THE KIDNEY IN A PATIENT TREATED BY DIALYSIS.Patient treated by dialysis for end-stage renal disease are at increased risk of many cancers, especially those of kidney and urinary tract. A 56 years old man who undergoing chronic dialysis, presented in ultrasonography a 2 cm complex cystic mass in the left kidney what was confirmed by computed tomography and magnetic resonance.A laparoscopic left nephrectomy was performed. Histological examination showed a low grade collecting duct carcinoma of the kidney. An infrequent variant of kidney tumor. NOTA CLÍNICA L os pacientes en hemodiálisis crónica pueden presentar quistes renales múltiples en una proporción elevada, conociéndose como enfermedad renal quística adquirida, y además desarrollar lesiones benignas y malignas en sus riñones naturales 1,2 .El potencial maligno de los tumores renales en pacientes con fracaso renal crónico es bajo, ya que se trata de neoformaciones bien diferenciadas, de pequeñas dimensiones y curso asintomático 1 , tal como sucedió en el enfermo que presentamos. Lo particular del caso fue que en el estudio histológico de la tumoración renal nos encontramos un carcinoma renal de los túbulos colectores de Bellini, una variante que supone el 1-3% de todos los tumores renales 3 . CASO CLÍNICOPaciente de 56 años de edad, con antecedentes personales de insuficiencia renal crónica de etiología no filiada (probable nefroangioesclerosis) en tratamiento con hemodiálisis, hipertensión arterial, cardiopatía isquémica y prostatismo, que ingresa en nuestro Servicio procedente del Servicio de Nefrología, por el hallazgo casual de una lesión quística en polo inferior de riñón izquierdo en una ecografía.El paciente se encuentra asintomático, con la exploración, la analítica general y la radiografía simple del aparato urinario dentro de la normalidad.Una ecografía abdominal realizada en el contexto de su insuficiencia renal crónica muestra unos 560Martín Martín S et al./Actas Urol Esp. 2008;32(5):559-562 riñones de pequeño tamaño, con mala diferenciación córtico-medular y un adelgazamiento de la cortical. En el riñón izquierdo se evidencia una lesión quística de pequeño tamaño, con discreto contenido ecogénico en su interior, compatible con un quiste complicado (Fig. 1).Ante los hallazgos e...

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“…In the case of sarcomatoid change, the survival decreases with the 5-year DSS of 35% (Amin et al 2002). A very rare entity of collecting duct RCC is highly aggressive with highly decreased prognosis (Antonelli et al 2003). The prognostic power of the Heidelberg classification has been investigated.…”

Section: Heidelberg and Who Classifications For Typing Of Renal Tumorsmentioning

confidence: 99%

Prognostic Factors in Renal Cell Carcinoma: An Evaluation of T-Stage, Histopathological Grade, p53, Ki-67, COX-2, and Her-2 Expressions

Kankuri-Tammilehto¹

2012

Emerging Research and Treatments in Renal Cell Carcinoma

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The Collecting Duct Carcinoma of the Kidney: A Cytogenetical Study

Cited by 41 publications

References 16 publications

Bellini's duct carcinoma: A report of two cases and a review of the literature

Bellini's duct carcinoma: A report of two cases and a review of the literature

Carcinoma renal de los conductos colectores de bajo grado en un paciente en tratamiento con hemodiálisis

Prognostic Factors in Renal Cell Carcinoma: An Evaluation of T-Stage, Histopathological Grade, p53, Ki-67, COX-2, and Her-2 Expressions

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