The Collagen-binding Integrin α2β1 Is a Novel Interaction Partner of the Trimeresurus flavoviridis Venom Protein Flavocetin-A

Abstract

Background: Snake venoms contain antagonists of the collagen-binding integrin ␣2␤1. Results: Flavocetin-A binds to the integrin ␣2A domain and inhibits cell adhesion and migration on collagen. Conclusion: Flavocetin-A is a novel interaction partner of integrin ␣2␤1. Significance: ␣2␤1 antagonists from snake venoms can be utilized for drug development.

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