Assessment of activity and mechanism of action of β-Dglucan against dengue virus

Song, Yonghong; Zhang, Wenzhi; Jaganathan, Ravindran

doi:10.4314/tjpr.v17i6.12

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…The potential of the AFO-202 and N-163 beta glucan as an immune adjuvant in the prophylaxis of COVID-19, along with beneficial anti-coagulopathy benefits in clinical trials, has been described (16)(17)(18)(19)(20). These beta glucans have also been effective as inti-infective agents against viral infections such as dengue, influenza, rabies apart from beneficial immune-modulation in sepsis (21)(22)(23)(24).…”

Section: N-163 Benefitsmentioning

confidence: 99%

Beta 1,3-1,6 Glucans Produced by Two Novel Strains of Aureobasidium Pullulans Exert Immune and Metabolic Beneficial Effects in Healthy Middle-aged Japanese Men: Results of an Exploratory Randomized Control Study

Ikewaki¹,

Sonoda²,

Kurosawa³

et al. 2023

J Aging Res & Lifestyle

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Objectives In this pilot study, we have evaluated the specific metabolic and immune-related benefits of the AFO-202 strain and N-163 strain of black yeast Aureobasidium pullulans-produced beta 1,3-1,6 glucan in healthy human subjects. Methods Sixteen healthy Japanese male volunteers (aged 40 to 60 years) took part in this clinical trial. They were divided into four groups (n = 4 each): Group I consumed AFO-202 beta-glucan (2 sachets of 1 g each per day), IA for 35 days and IB for 21 days; Group II consumed a combination of AFO-202 beta-glucan (2 sachets of 1 g each) and N-163 beta-glucan (1 sachet of 15 g gel each per day), IIA for 35 days and IIB for 21 days. Results Decrease in HbA1C and glycated albumin (GA), significant increase of eosinophils and monocytes and marginal decrease in D-dimer levels, decrease in neutrophil-to-lymphocyte ratio (NLR), with an increase in the lymphocyte-to-CRP ratio (LCR) and leukocyte-to-CRP ratio (LeCR) was observed in Group I between pre- and post-treatment. Decrease in total and LDL cholesterol, a decrease of CD11b, serum ferritin, galectin-3 and fibrinogen were profound in Group II between pre- and post-treatment. However, there was no statistically significant difference between day 21 and day 35 among the groups. Conclusion This outcome warrants larger clinical trials to explore the potentials of these safe food supplements in the prevention and prophylaxis of diseases due to dysregulated metabolism, such as fatty liver disease, and infections such as COVID-19 in which balanced immunomodulation are of utmost importance, besides their administration as an adjunct to existing therapeutic approaches of both communicable and non-communicable diseases.

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Section: N-163 Benefitsmentioning

confidence: 99%

Beta 1,3-1,6 Glucans Produced by Two Novel Strains of Aureobasidium Pullulans Exert Immune and Metabolic Beneficial Effects in Healthy Middle-aged Japanese Men: Results of an Exploratory Randomized Control Study

Ikewaki¹,

Sonoda²,

Kurosawa³

et al. 2023

J Aging Res & Lifestyle

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“…Specific β and α‐ d ‐glucans show anti‐DENV activity by binding to the virus E protein, inhibiting its entry into cells, [ 253 ] causing its detachment from cells, [ 254 ] and suppressing protein synthesis. [ 94 ] Sulfonated glucan derivatives also exhibit anti‐HSV activity via interacting with the positively charged receptors of enveloped viruses. In contrast, they do not exhibit antiviral activity against poliovirus (nonenveloped).…”

Section: Polymers Against Virusesmentioning

confidence: 99%

From Bulk to Nanoparticles: An Overview of Antiviral Materials, Its Mechanisms, and Applications

Rodrigues

Campo

Arns

et al. 2021

Part & Part Syst Charact

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Infectious diseases caused by viruses are a global health concern and have become prominent in light of the recent COVID‐19 pandemic. Considering the limitations of drugs and prophylactic methods used in current medicine, antiviral materials are a useful strategy in preventing the spread of viruses and enhancing treatment efficiency. Thus, this review highlights the state‐of‐the‐art antiviral materials, describes the scientific landscape of the primary antiviral materials used based on bibliometric analysis, presents their mechanisms of action, and discusses their clinical applications. The mechanisms of action underlying the broad‐spectrum antiviral properties of metals, ceramics, polymers, and composites are also discussed. Polyanions, polycations, oxides, and metal‐based materials, from bulk to nanoparticles, have good potential in antiviral applications that may help prepare the world for future viral breakouts.

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“…Nowadays, β-glucans have attracted considerable attention due to their anti-infective, antiviral, antitumor, and immunomodulatory activities as well as wound healing properties [2][3][4][5][6][7]. As for their antiviral effect, β-glucans have shown excellent activity against a broad spectrum of plant, animal, and human viruses, such as the infectious haematopoietic necrosis virus [8], spring viremia of carp virus [9], dengue virus [10], herpes simplex virus type 1 (HSV-1) [11], human immunodeficiency virus 1 [12], influenza virus [13,14], and tobacco mosaic virus [15]. Despite in vitro and in vivo evidence of the antiviral effect of β-glucans, to date, only a few human and animal clinical studies have been conducted utilizing β-glucans in treatment or prevention of viral infections [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Pleuran (β‐Glucan from Pleurotus ostreatus) in the Management of Herpes Simplex Virus Type 1 Infection

Urbancikova

Hudackova²,

Majtán

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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One of the highly prevalent viral pathogens among children and adults causing infection, clinically presenting as herpes labialis, is herpes simplex virus type 1 (HSV-1). The long-term administration of acyclovir, a standard regimen for therapy against HSV-1 infections, can cause viral resistance against this drug. Therefore, the development of natural drugs with low toxicity that are able to enhance host antiviral defense against HSV infection is needed. β-Glucans represent a type of biologically active molecules possessing antiviral properties. The goal of this study was to investigate the clinical and immunomodulatory effect of β-glucan pleuran (insoluble β-1,3/1,6-D-glucan isolated from Pleurotus ostreatus) based supplements on the duration and intensity of herpes symptoms and on the incidence rate and duration of acute respiratory symptoms and intercurrent diseases in HSV-1 positive patients. Ninety patients were randomised into active and placebo groups. Active treatment with pleuran in systemic application caused a significantly shorter duration of herpes simplex symptoms compared to the placebo group. During the preventive phase (120 days), the duration and severity of respiratory symptoms were lower in the active group compared to the placebo group; however, a significant difference was found only in the case of cough. No significant side effects were observed during both phases of the clinical trial (acute and preventive). Obtained results suggest that the use of pleuran seems to be a promising approach in the treatment of acute HSV-1 with beneficial effect on the respiratory tract symptoms and infections.

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Assessment of activity and mechanism of action of β-Dglucan against dengue virus

Cited by 4 publications

References 23 publications

Beta 1,3-1,6 Glucans Produced by Two Novel Strains of Aureobasidium Pullulans Exert Immune and Metabolic Beneficial Effects in Healthy Middle-aged Japanese Men: Results of an Exploratory Randomized Control Study

Beta 1,3-1,6 Glucans Produced by Two Novel Strains of Aureobasidium Pullulans Exert Immune and Metabolic Beneficial Effects in Healthy Middle-aged Japanese Men: Results of an Exploratory Randomized Control Study

From Bulk to Nanoparticles: An Overview of Antiviral Materials, Its Mechanisms, and Applications

Efficacy of Pleuran (β‐Glucan from Pleurotus ostreatus) in the Management of Herpes Simplex Virus Type 1 Infection

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