The Cognitive-Enhancing Effects of Dendrobium nobile Lindl Extract in Sleep Deprivation-Induced Amnesic Mice

Abstract

Chronic sleep deprivation (SD) causes neurological and neurodegenerative dysfunction including learning and memory deficit. The orchid Dendrobium nobile Lindl (DNL), is widely used as a Yin tonic and medicinal food throughout Asia, and has many reported pharmacological effects. This study focused on the cognitive-enhancing effects of DNL in sleep deprivation-induced amnesia in mice and its biochemical mechanisms. Our results showed that the mice displayed significant cognitive deficits after 2-week SD while treatment with the extract of DNL prevented these impairments. In the novel object recognition and object location recognition tasks, a significant increase in the discrimination index was observed in DNL-treated (200 and 400 mg/kg) mice. In the MWM test, DNL (200 and 400 mg/kg) treatment shorten the prolongation of latency and increased the crossing numbers compared with SD mice. The biochemical analysis of brain tissue showed a decrease in NE, dismutase (T-SOD) and catalase (CAT) activity and an increase in 5-HT and malondialdehyde (MDA) concentration after the treatment with DNL in mice. Our findings indicated that DNL exerted a positive effect in preventing and improving cognitive impairment induced by SD, which may be mediated via the regulation of neurotransmitters and alleviation of oxidative stress.

The potential for traditional Chinese therapy in treating sleep disorders caused by COVID-19 through the cholinergic anti-inflammatory pathway

“…However, there are still some limitations in the studies related to poor methodology in Chinese herbal medicine, such as complex chemical compositions and unclear efficacy that might be the result of the comprehensive action of all drug ingredients, which to some extent restrict clear conclusions. In addition, many other TCT treatments have also improved sleep disorders ( Cho et al, 2013 ; Bergdahl et al, 2017 ; Karadag et al, 2017 ; Li et al, 2018 ; Meng et al, 2018 ; Jiao et al, 2020 ; Hu et al, 2021 ; Jiang et al, 2021 ; Jiang et al, 2022a ; Jiang et al, 2022b ). Table 3 summarizes the effects of most TCT treatments on sleep disorders under different conditions.…”

Study on acupuncture improving sleep deprivation comorbid with cognitive dysfunction based on rs-fMRI: A protocol for systematic review and meta-analysis

“…As the treasure of China, traditional Chinese acupuncture has a long history, safety, and effectiveness, and has been widely respected in clinical application. A large number of animal experiments and related clinical studies have confirmed the safety and effect of acupuncture in the treatment of SD with cognitive dysfunction, [ 10 , 11 ] but the specific mechanism remains to be further explored.…”