Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway

Yao, Caihong; Zhang, Yiwen; Sun, Xinran; Pei, Haiyue; Wei, Shanshan; Wang, Mengdi; Chen, Qi; Liu, Xinmin; Jiang, Ning

doi:10.1016/j.biopha.2023.114459

Cited by 3 publications

(2 citation statements)

References 59 publications

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“…Besides, this GY-13 can significantly restore the expression level of cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), brain-derived neurotrophic factor (BDNF), and cAMP response element binding (CREB), and increase the proliferative activity in the hippocampus, thereby improving depressive behaviors [ 115 ]. Yao et al proved that areca nut can improve depressive behavior by activating the BDNF signaling pathway as well [ 116 ].…”

Section: Functional Effects Of Areca Nut Componentsmentioning

confidence: 99%

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Sun,

Yu,

et al. 2024

Nutrients

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Areca catechu L. is a widely cultivated tropical crop in Southeast Asia, and its fruit, areca nut, has been consumed as a traditional Chinese medicinal material for more than 10,000 years, although it has recently attracted widespread attention due to potential hazards. Areca nut holds a significant position in traditional medicine in many areas and ranks first among the four southern medicines in China. Numerous bioactive compounds have been identified in areca nuts, including alkaloids, polyphenols, polysaccharides, and fatty acids, which exhibit diverse bioactive functions, such as anti-bacterial, deworming, anti-viral, anti-oxidant, anti-inflammatory, and anti-tumor effects. Furthermore, they also display beneficial impacts targeting the nervous, digestive, and endocrine systems. This review summarizes the pharmacological functions and underlying mechanisms of the bioactive ingredients in areca nut. This helps to ascertain the beneficial components of areca nut, discover its medicinal potential, and guide the utilization of the areca nut.

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Section: Functional Effects Of Areca Nut Componentsmentioning

confidence: 99%

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Sun,

Yu,

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…As part of the limbic system, the hippocampus is involved in regulating emotion-related processes and has a crucial role in negative emotions that occur with depression and anxiety [ 7 , 8 ]. Increasing hippocampal neurogenesis has been found to improve stress-induced anxiety- and depressive-like behaviors [ 9 , 10 ]. Additionally, activating microglia in the hippocampus promotes the occurrence of depressive-like behaviors [ 11 ], while inhibiting microglial activation and neuroinflammation improves depressive-like behaviors in mice [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

GPR55 activation improves anxiety- and depression-like behaviors of mice during methamphetamine withdrawal

Zhang,

Yan,

et al. 2024

Heliyon

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Hormetic effect of benzo(α)pyrene and latilactobacillus plantarum CCFM726 against benzo(α)pyrene toxicity

Ye,

Zhang,

et al. 2024

Food Bioscience

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Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway

Cited by 3 publications

References 59 publications

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

GPR55 activation improves anxiety- and depression-like behaviors of mice during methamphetamine withdrawal

Hormetic effect of benzo(α)pyrene and latilactobacillus plantarum CCFM726 against benzo(α)pyrene toxicity

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