The Coexistence of Carcinoma and Tuberculosis in One Breast: A Case Report and Literature Review

Farrokh, Donya; Marashi, Mahdis; Rastegar, Yalda Fallah; Mashhadi, Samine Boloursaz

doi:10.5812/ijcm.6185

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…The mammographic features of the nodular type are often dense masses with indistinct margins, without the classic halo sign found in benign breast masses (Figures 2 and 3) (Tewari and Shukla, 2005;Khanna et al, 2002;Longman et al, 2017). The breast mass may demonstrate irregular, speculated margins resembling breast carcinoma (Figure 3) (Madhusudhan and Gamanagatti, 2008;Farrokh et al, 2017;Thimmappa et al, 2015). The healed granuloma may also be evident as calcification on mammography.…”

Section: Imaging Characteristicsmentioning

confidence: 99%

“…Tulasi et al have reported a case of infiltrating ductal carcinoma of the breast and metastasis to the axillary lymph node with evidence of tubercular granuloma in the same lymph node (Tulasi et al, 2006). It is important to remember that the recognition of TB does not exclude the presence of concomitant breast carcinoma (Pujani et al, 2015) and this coexistence causes serious problems regarding diagnosis and treatment (Farrokh et al, 2017;Pujani et al, 2015).…”

Section: Imaging Characteristicsmentioning

confidence: 99%

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Tuberculous mastitis: A review of 32 cases

Farrokh

Alamdaran

Laeen

et al. 2019

International Journal of Infectious Diseases

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Background: Breast tuberculosis (TB) is a rare disease, still present in endemic areas. The significance of breast TB is due to its rare occurrence and its resemblance to malignant breast lesions. The objective of this study was to study various clinical presentations and imaging features of different forms of tuberculous mastitis. Methods: A retrospective study was conducted over a 10-year period. Thirty-two consecutive patients diagnosed with tuberculous mastitis were included. Results: There was only one male patient in this series. The patients ranged in age from 25 to 60 years (mean age was 33.69 years). A solitary breast mass was the most common clinical presentation, which was associated with inflammatory findings in the majority of cases. The most common mammographic finding was diffusely increased density and the most common pathological finding was solitary mass. The most common appearance on ultrasound was of multiple intercommunicating breast masses with axillary lymphadenopathy. Conclusions: Breast TB should be considered in the differential diagnosis in the presence of a painful breast mass, discharging sinuses, mastitis, or a breast abscess that does not respond to conventional medical treatment. A multidisciplinary approach is required to aid timely diagnosis and to provide appropriate management and treatment in order to avoid complications.

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Section: Imaging Characteristicsmentioning

confidence: 99%

Section: Imaging Characteristicsmentioning

confidence: 99%

Tuberculous mastitis: A review of 32 cases

Farrokh

Alamdaran

Laeen

et al. 2019

International Journal of Infectious Diseases

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“…Farrokh et al and Tulasi et al have reported cases of the coexistence of carcinoma and mammary tuberculosis. Hence, it is necessary to bear in mind this possibility when dealing with granulomatous mastitis [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Breast Tuberculosis Concealed Behind Granulomatous Mastitis

Tahri¹,

Hamaz²,

Bachir³

et al. 2023

Cureus

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Granulomatous mastitis is an inflammatory disease that often affects women with a history of breastfeeding. The pathogenesis is still unclear and several factors have been incriminated, such as trauma, metabolic and hormonal disorders, infections, and autoimmunity. This poses a diagnostic issue, given that there are several different diagnoses, particularly carcinomatous mastitis.We report the case of a 32-year-old woman, with a history of breastfeeding, who presented with inflammatory left breast. The physical examination has objectified a 10/10 cm painless mass and a 3 cm homolateral axillary lymphadenopathy. A sonomammography revealed inflammatory left breast infiltration with multiple collections associated with homolateral axillary lymphadenopathies. A Trucut biopsy was performed, revealing granulomatous mastitis without signs of malignancy. Interferon-gamma measurement and Koch Bacillus (BK) search by polymerase chain reaction (PCR) in the breast collection were all negative. The patient was put on non-specific antibiotics with no response and clinical worsening; therefore, we were obliged to start bacillary treatment. The evolution was marked by a total drought and the disappearance of inflammatory signs within a few weeks.Mammary tuberculosis poses a diagnostic issue given the difficulty to identify the bacteria in the samples. This is why tuberculosis should never be excluded despite negative results, especially in endemic countries.

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“…Tulasi et al have reported a case of infiltrating ductal carcinoma of the breast and metastasis to the axillary lymph node with evidence of tubercular granuloma in the same lymph node [ 25 ]. Farrokh et al reported coexistence of breast carcinoma and TM in one breast [ 26 ]. Similar case reports have been published in the literature [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Is it tuberculosis mastitis or granulomatous mastitis? A thirteen-year experience at a university hospital

Köseoğlu¹,

Dasiran²,

Köseoğlu³

et al. 2023

Turkish Journal of Medical Sciences

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Background/aim Granulomatous mastitis (GM) is a rare inflammatory disease of the breast. Tuberculosis mastitis (TM), one of the causes of GM, is a rare form of extrapulmonary tuberculosis. The clinical, radiological, and histopathological findings of TM and GM are similar, and sometimes it is difficult to make a distinction between these disease states. In this study, we aimed to evaluate the clinical and radiological features, diagnostic techniques, treatment modalities and treatment outcomes of the patients with GM and TM. Materials and methods The data of the patients with confirmed GM by histopathologic examination of biopsy specimens between 2007 and 2020 were retrospectively analyzed. Demographic features, main complaints, physical findings, radiological and laboratory data, treatment modalities, and treatment outcomes were recorded. Results Sixty-eight GM patients with a mean age of 35.8 (18–63) years were evaluated. The patients had a mass lesion, pain, ulceration, and abscess in their breasts. All of the cases were female. Ultrasonographic examinations were performed on 62 cases. Abscess and/or sinus tract formation was detected in 34, heterogeneous hypoechoic mass in 15, heterogeneous parenchyma or parenchymal edema in 15, axillary lymphadenopathy in 18 and cysts in 13 patients. A total of 10 patients were lost to follow-up. Twenty-six patients underwent surgery for their breast lesions or had antibiotherapy (n = 13) or corticosteroid therapy (n = 7). Eleven (16.1%) patients were diagnosed with TM. These patients were evaluated by clinical examination, chest radiography, and tuberculin skin test. Acid-fast bacilli (AFB) staining and culture were negative in all cases. The diagnosis of TM was based on histopathological evaluation results. Eight of the 11 patients achieved complete remission with antituberculosis treatment. Conclusion The etiological diagnosis of GM must be based on a multidisciplinary approach. Tuberculosis mastitis should become a part of differential diagnosis of breast diseases in populations with high incidence of tuberculosis.

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The Coexistence of Carcinoma and Tuberculosis in One Breast: A Case Report and Literature Review

Cited by 5 publications

References 10 publications

Tuberculous mastitis: A review of 32 cases

Tuberculous mastitis: A review of 32 cases

Primary Breast Tuberculosis Concealed Behind Granulomatous Mastitis

Is it tuberculosis mastitis or granulomatous mastitis? A thirteen-year experience at a university hospital

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