The Cochleural Alternating Acoustic Beam Therapy (CAABT): A pre-clinical trial

Liu, Chunli; Lv, Han; Jiang, Tao; Xie, Jing; Hé, Lǚ; Wang, Guo‐Peng; Liu, Jiao; Wang, Zhenchang; Gong, Shusheng

doi:10.1016/j.amjoto.2018.04.002

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…Current therapeutic approaches include tinnitus retraining therapy (Scherer et al, 2014; Kim et al, 2016), counseling, cognitive behavior therapy (Conrad et al, 2015; Weise et al, 2016), transcranial magnetic stimulation (Kreuzer et al, 2017; Formanek et al, 2018), hearing aids (Searchfield et al, 2010), pharmacological treatments (von Boetticher, 2011), and several innovative sound-based treatments (e.g., Heidelberg Neuro-Music Therapy) (Krick et al, 2015, 2017a,b), Cochleural Alternating Acoustic Beam Therapy (CAABT) (Liu et al, 2018), and Tailor-Made Notched Music Training (TMNMT) (Okamoto et al, 2010; Kim et al, 2017; Lee et al, 2017). Sound therapy is considered as a cost-effective management for tinnitus (Tunkel et al, 2014; Walker et al, 2016; Makar et al, 2017) and is one of the most commonly used first-line therapy interventions for decades (Henry et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Baseline Functional Connectivity Features of Neural Network Nodes Can Predict Improvement After Sound Therapy Through Adjusted Narrow Band Noise in Tinnitus Patients

Zeng

Liu

et al. 2019

Front. Neurosci.

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Previous resting-state functional magnetic resonance imaging (fMRI) studies have shown neural connectivity alterations after the treatment of tinnitus. We aim to study the value of the baseline functional connectivity features of neural network nodes to predict outcomes of sound therapy through adjusted narrow band noise. The fMRI data of 27 untreated tinnitus patients and 27 matched healthy controls were analyzed. We calculated the graph-theoretical metric degree centrality (DC) to characterize the functional connectivity of the neural network nodes. Therapeutic outcomes are determined by the changes in the Tinnitus Handicap Inventory (THI) score after a 12-week intervention. The connectivity of 10 brain nodes in tinnitus patients was significantly increased at baseline. The functional connectivity of right insula, inferior parietal lobule (IPL), bilateral thalami, and left middle temporal gyrus was significantly modified with the sound therapy, and such changes correlated with THI changes in tinnitus patients. Receiver operating characteristic curve analyses revealed that the measurements from the five brain regions were effective at classifying improvement after therapy. After age, gender, and education correction, the adjusted area under the curve (AUC) values for the bilateral thalami were the highest (left, 0.745; right, 0.708). Our study further supported the involvement of the fronto-parietal-cingulate network in tinnitus and found that the connectivity of the thalamus at baseline is an object neuroimaging-based indicator to predict clinical outcome of sound therapy through adjusted narrow band noise.

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Section: Introductionmentioning

confidence: 99%

Baseline Functional Connectivity Features of Neural Network Nodes Can Predict Improvement After Sound Therapy Through Adjusted Narrow Band Noise in Tinnitus Patients

Zeng

Liu

et al. 2019

Front. Neurosci.

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“…The experiment was conducted following a previously published randomized controlled trial protocol 16 . All participants underwent audiological and tinnitus-related examinations.…”

Section: Methodsmentioning

confidence: 99%

“…Vernon 10 demonstrated that tinnitus masking, a standard monotone therapy, involves using external noise to distract the patient's attention and reduce the contrast between the tinnitus signal and background activity within the auditory system. Advancements in portable devices, such as smartphones, have led to the development of cochleural alternating acoustic beam therapy (CAABT) 11 ; this method uses various sound therapy algorithms to modify the sound in all dimensions, adapting to the patient’s needs over time. It is a sound therapy that focuses on specific tinnitus frequencies and relies on clinical tinnitus assessment methods for intervention.…”

Section: Introductionmentioning

confidence: 99%

Therapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patients

Liu,

Zhang,

et al. 2024

Sci Rep

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Idiopathic tinnitus is a common and complex disorder with no established cure. The CAABT (Cochleural Alternating Acoustic Beam Therapy CAABT), is a personalized sound therapy designed to target specific tinnitus frequencies and effectively intervene in tinnitus according to clinical tinnitus assessment. This study aimed to compare the effectiveness of the CAABT and Traditional Sound Therapy (TST) in managing chronic idiopathic tinnitus. This was a randomized, double-blind, parallel-group, single-center prospective study. Sixty adult patients with tinnitus were recruited and randomly assigned to the CAABT or TST group in a 1:1 ratio using a computer-generated randomization. The treatment lasted for 12 weeks, and participants underwent assessments using the tinnitus handicap inventory (THI), visual analog scale (VAS), tinnitus loudness measurements, and resting-state functional magnetic resonance imaging (rs-fMRI). Both groups showed significant reductions in THI scores, VAS scores, and tinnitus loudness after treatment. However, CAABT showed superiority to TST in THI Functional (p = 0.018), THI Emotional (p = 0.015), THI Catastrophic (p = 0.022), THI total score (p = 0.005) as well as VAS score (p = 0.022). More interesting, CAABT showed superiority to TST in the changes of THI scores, and VAS scores from baseline. The rs-fMRI results showed significant changes in the precuneus before and after treatment in both groups. Moreover, the CAABT group showed more changes in brain regions compared to the TST. No side effects were observed. These findings suggest that CAABT may be a promising treatment option for chronic idiopathic tinnitus, providing significant improvements in tinnitus-related symptoms and brain activity.Trial registration: ClinicalTrials.gov:NCT02774122.

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Sense and Sensibility: A Review of the Behavioral Neuroscience of Tinnitus Sound Therapy and a New Typology

Searchfield

2020

The Behavioral Neuroscience of Tinnitus

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The Cochleural Alternating Acoustic Beam Therapy (CAABT): A pre-clinical trial

Cited by 4 publications

References 20 publications

Baseline Functional Connectivity Features of Neural Network Nodes Can Predict Improvement After Sound Therapy Through Adjusted Narrow Band Noise in Tinnitus Patients

Baseline Functional Connectivity Features of Neural Network Nodes Can Predict Improvement After Sound Therapy Through Adjusted Narrow Band Noise in Tinnitus Patients

Therapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patients

Sense and Sensibility: A Review of the Behavioral Neuroscience of Tinnitus Sound Therapy and a New Typology

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