Sense and Sensibility: A Review of the Behavioral Neuroscience of Tinnitus Sound Therapy and a New Typology

Searchfield, Grant D.

doi:10.1007/7854_2020_183

Cited by 6 publications

(3 citation statements)

References 169 publications

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“…TRT combines counseling and partial masking (either with sound generators or hearing aids) to modify pathological brain activity as well as promote habituation, and is widely used in clinical practice. However, there is mixed evidence on the efficacy of TRT (Grewal et al, 2014;Barozzi et al, 2017;Bauer et al, 2017;Zenner et al, 2017;Searchfield, 2020). In addition, different applications of simultaneous multimodal stimulation have shown promising results e.g., combination of sound and somatosensory stimulation (Marks et al, 2018;Conlon et al, 2020).…”

Section: Combination Of Interventionsmentioning

confidence: 99%

Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

Simões

Daoud

Shabbir

et al. 2021

Front. Aging Neurosci.

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Tinnitus can be a burdensome condition on both individual and societal levels. Many aspects of this condition remain elusive, including its underlying mechanisms, ultimately hindering the development of a cure. Interdisciplinary approaches are required to overcome long-established research challenges. This review summarizes current knowledge in various tinnitus-relevant research fields including tinnitus generating mechanisms, heterogeneity, epidemiology, assessment, and treatment development, in an effort to highlight the main challenges and provide suggestions for future research to overcome them. Four common themes across different areas were identified as future research direction: (1) Further establishment of multicenter and multidisciplinary collaborations; (2) Systematic reviews and syntheses of existing knowledge; (3) Standardization of research methods including tinnitus assessment, data acquisition, and data analysis protocols; (4) The design of studies with large sample sizes and the creation of large tinnitus-specific databases that would allow in-depth exploration of tinnitus heterogeneity.

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Section: Combination Of Interventionsmentioning

confidence: 99%

Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

Simões

Daoud

Shabbir

et al. 2021

Front. Aging Neurosci.

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“…Hearing Aids (HAs) have been used as tinnitus management tools since at least the late 1940s ( 37 ) and this continued with the arrival of fully digital aids in the mid 1990s. HA are used in tinnitus management to reduce accompanying hearing handicap, reduce the levels of attention paid to tinnitus, compensate for deafferentation, and by raising the audibility of environmental sounds so that tinnitus can be masked ( 38 ). In the early 2000s the United Kingdom National Health Service modernized their hearing aid program, and digital aids became available to NHS patients.…”

Section: Resultsmentioning

confidence: 99%

A State-of-Art Review of Digital Technologies for the Next Generation of Tinnitus Therapeutics

Searchfield

Sanders

Doborjeh

et al. 2021

Front. Digit. Health

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Background: Digital processing has enabled the development of several generations of technology for tinnitus therapy. The first digital generation was comprised of digital Hearing Aids (HAs) and personal digital music players implementing already established sound-based therapies, as well as text based information on the internet. In the second generation Smart-phone applications (apps) alone or in conjunction with HAs resulted in more therapy options for users to select from. The 3rd generation of digital tinnitus technologies began with the emergence of many novel, largely neurophysiologically-inspired, treatment theories that drove development of processing; enabled through HAs, apps, the internet and stand-alone devices. We are now of the cusp of a 4th generation that will incorporate physiological sensors, multiple transducers and AI to personalize therapies.Aim: To review technologies that will enable the next generations of digital therapies for tinnitus.Methods: A “state-of-the-art” review was undertaken to answer the question: what digital technology could be applied to tinnitus therapy in the next 10 years? Google Scholar and PubMed were searched for the 10-year period 2011–2021. The search strategy used the following key words: “tinnitus” and [“HA,” “personalized therapy,” “AI” (and “methods” or “applications”), “Virtual reality,” “Games,” “Sensors” and “Transducers”], and “Hearables.” Snowballing was used to expand the search from the identified papers. The results of the review were cataloged and organized into themes.Results: This paper identified digital technologies and research on the development of smart therapies for tinnitus. AI methods that could have tinnitus applications are identified and discussed. The potential of personalized treatments and the benefits of being able to gather data in ecologically valid settings are outlined.Conclusions: There is a huge scope for the application of digital technology to tinnitus therapy, but the uncertain mechanisms underpinning tinnitus present a challenge and many posited therapeutic approaches may not be successful. Personalized AI modeling based on biometric measures obtained through various sensor types, and assessments of individual psychology and lifestyles should result in the development of smart therapy platforms for tinnitus.

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“…The pathogenesis of tinnitus remains unclear, which is probably related to abnormal variations on the auditory pathway [ 8 ]. Tinnitus frequency is often corresponding to the hearing impairment region inside the cochlea [ 2 ], thus we invented a strategy to modulate the peaceful music and jointly enhance the upper and lower frequency band adjacent to tinnitus pitch based on the lateral inhibiting effect [ 27 , 28 ], and the modified sound could be generated and played via our patented software/APP named Fudan Tinnitus Relieving System (FTRS). We plan to verify and compare the clinal efficacy of MTRS to UM in the current RCT.…”

Section: Discussionmentioning

confidence: 99%

The clinical effects of modified tinnitus relieving sound (MTRS) for chronic tinnitus: protocol for a randomized controlled trial

Tang

Wang

et al. 2023

Trials

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Introduction Chronic subjective tinnitus has become an increasingly serious hazard that affects the health-related quality of life for millions of people. Due to the lack of curative treatment strategies, this study aims to introduce a novel acoustic therapy named the modified tinnitus relieving sound (MTRS) for tinnitus and to evaluate the efficacy of MTRS in comparison with unmodified music (UM) which served as a control. Methods and analysis A randomized, double-blinded, controlled, clinical trial will be carried out. Sixty-eight patients with subjective tinnitus will be recruited and randomly allocated into two groups in 1:1 ratio. The primary outcome is Tinnitus Handicapped Inventory (THI); the secondary outcomes are the Hospital Anxiety and Distress Scale (HADS; HADS subscales for Anxiety (HADS-A) and Depression (HADS-D)), Athens Insomnia Scale (AIS), the visual analog scale (VAS) for tinnitus, and tinnitus loudness matched by sensation level (SL). Assessment will be performed at baseline and at 1, 3, 9, and 12 months post-randomization. The sound stimulus will be persistent until 9 months after randomization, and be interdictory in the last three months. Data collected during the intervention process will be analyzed and compared to baseline. Ethics and dissemination This trial received ethical approval from the Institutional Review Board (IRB) of Eye & ENT Hospital of Fudan University (No. 2017048). The study results will be disseminated via academic journals and conferences. Funding This study is supported by the Shanghai Shenkang Development Program (SHDC12019119), the Excellent Doctors-Excellent Clinical Researchers Program (SYB202008), the Shanghai Rising-Star Program (23QC1401200), the Shanghai Rising Stars of Medical Talent Youth Development Program (2021–99), the National Natural Science Foundation of China (81800912), and the National Natural Science Foundation of Shanghai (21ZR1411800). Trial registration ClinicalTrials.gov NCT04026932. Registered on 18 July 2019.

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Sense and Sensibility: A Review of the Behavioral Neuroscience of Tinnitus Sound Therapy and a New Typology

Cited by 6 publications

References 169 publications

Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

A State-of-Art Review of Digital Technologies for the Next Generation of Tinnitus Therapeutics

The clinical effects of modified tinnitus relieving sound (MTRS) for chronic tinnitus: protocol for a randomized controlled trial

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