The Co Relation of Serum Uric Acid with Risk Factors and Severity of Coronary Artery Disease (CAD) in Acute Coronary Syndrome

George, Jisa; Sp, Kataria; Isser, HS

doi:10.21276/ijcmsr.2019.4.4.26

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Selain itu, kadar asam urat serum berkorelasi dengan jumlah aterosklerosis arteri koroner yang terkena pada pasien SKA. 13 Beberapa penelitian telah meneliti hubungan hiperurisemia dengan keparahan lesi arteri koroner dibandingkan normourisemia pada pasien SKA. Namun demikian, batasan definisi hiperurisemia yang digunakan berbeda-beda, sehingga hasilnya juga berbeda.…”

Section: Pendahuluanunclassified

Korelasi Kadar Asam Urat Serum dengan Keparahan Stenosis Arteri Koroner Pasien Sindrom Koroner Akut: Studi Meta-Analisis

Prasetyo¹,

Nasution

Alwi

et al. 2021

JPDI

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Pendahuluan. Hubungan antara asam urat serum dengan penyakit jantung iskemik masih kontroversial dan belum ditetapkan sebagai faktor risiko kardiovaskular. Interaksi kooperatif antara keduanya tidak sepenuhnya dipahami. Beberapa bukti epidemiologis hubungan kausal tersebut masih kontroversial. Sering sekali penelitian dengan kasus yang sama dan menggunakan metode yang sama tetapi hasilnya berbeda. Penelitian ini bertujuan untuk melakukan meta-analisis untuk mensintesis hasil-hasil penelitian yang berbeda tersebut agar diperoleh data baru yang bersifat kuantitatif dan lebih akurat.Metode. Protokol penelitian didaftarkan dengan PROSPERO (CRD42020210948) dan telaah sistematis mengikuti pedoman preferred reporting items for systematic reviews and meta-analyses (PRISMA), dengan menelusuri studi yang dipublikasikan dalam rentan waktu dari Januari 2010 hingga Mei 2020. Cochrane Library, EBSCO, Medline/PubMed, ProQuest dan Sience Direct adalah sumber dari studi yang dipublikasikan. Meta-analisis dilakukan untuk mensintesis korelasi antara kadar asam urat serum dan keparahan stenosis arteri koroner, menggunakan model efek acak untuk menjelaskan kemungkinan heterogenitas penelitian. Heterogenitas dinilai menggunakan I 2 , dan meta-analisis menggunakan perangkat lunak comprehensive meta-analysis version 3 (CMA3).Hasil. Lima studi (n = 601 pasien) diidentifikasi dan didapatkan korelasi antara kadar asam urat serum dan skor Gensini (r = 0,548; p <0,001) pada pasien SKA. Bias heterogenitas ditemukan dalam analisis, sedangkan bias publikasi tidak ditemukan. Terdapat korelasi positif antara kadar asam urat serum dengan keparahan stenosis arteri koroner, dengan koefisien korelasi sebesar 0,548 yang dapat dikategorikan memiliki hubungan yang sedang (nilai p <0,001).Simpulan. Keparahan stenosis arteri koroner pada pasien dengan SKA berkorelasi positif dengan kadar asam urat serum.

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Section: Pendahuluanunclassified

Korelasi Kadar Asam Urat Serum dengan Keparahan Stenosis Arteri Koroner Pasien Sindrom Koroner Akut: Studi Meta-Analisis

Prasetyo¹,

Nasution

Alwi

et al. 2021

JPDI

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“…4 In acute coronary syndrome patients, those with hyperuricemia suffered more coronary vessel number involvement than those with normal uric acid levels. 5 Patients with atherosclerotic plaque in the thoracic aorta had higher uric acid levels compared to normal ones. 6 A plasma protein known as C-reactive protein (CRP), which is primarily synthesized by the liver, has been associated with atherosclerosis due to several characteristics, including complement system activation, apoptosis, monocyte recruitment, accumulation of lipids, activation of the vascular cell, and thrombus formation.…”

Section: Introductionmentioning

confidence: 98%

Serum uric acid levels predict high hs-CRP levels in non-diabetic adult

Kurniawan,

Mulyamin,

Santoso

et al. 2023

Pol. Ann. Med.

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IntroductionHigh-sensitivity C-reactive protein (hsCRP) is a microinflammation biomarker that has been widely accepted as an assessment tool for cardiovascular risk. Excess of serum uric acid levels is also linked to metabolic disorders and cardiovascular disease risk factors.AimThe study aimed to investigate the association between serum uric acid and cardiovascular risk defined based on hsCRP levels in non-diabetic adults.Material and methodsThis cross-sectional study included 90 non-diabetic adult subjects which comprised 45 males and 45 females. The uric acid test was performed by enzymatic colorimetric method while hsCRP was performed by immunoturbidimetric assay. High cardiovascular risk was defined as hsCRP of more than 3 mg/L.Results and discussionSerum uric acid had significant correlation with hsCRP levels in male and female subjects (r = 0.376, P = 0.011 and r = 0.378, P = 0.011, respectively). In male subjects, the uric acid cut-off of 7.415 mg/dL had 62.5% sensitivity and 83.8% specificity in predicting high cardiovascular risk (AUC = 0.671), while in females, the cut-off of 4.215 mg/dL had 73.3% sensitivity and 63.3% specificity (AUC = 0.704) in predicting the high risk. Males with uric acid of more than 7.415 mg/dL had 8.61 times having high cardiovascular risk compared those below the cut-off (P = 0.014, 95%CI = 1.609–46.07). Females with uric acid of more than 4.215 mg/dL had 4.75 times having high cardiovascular risk compared those below the cut-off (P = 0.02, 95%CI = 1.214–18.584).ConclusionsUric acid and hsCRP levels have a significant association. Serum uric acid levels may predict high cardiovascular risk defined based on hsCRP in males and females.

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“…Furthermore, the SUA level associates with the amount of coronary artery atherosclerosis in patients with ACS. 8 Several studies have analyzed the correlation between hyperuricemia and severity of coronary artery disease by comparing them with normouricemia in ACS patients. However, the hyperuricemia terms have various boundaries and interpretations, causing differences in the results.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Serum Uric Acid Level and Severity of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome

Prasetyo

Nasution

Alwi

et al. 2021

mkb

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Acute coronary syndrome (ACS) is a life-threatening disease which remains one of the causes of high morbidity and mortality despite the current advances in treatment. The relationship between the serum uric acid (SUA) level and ischemic heart disease continues to be controversial and still has not been established as a cardiovascular risk factor. The cooperative interaction between the two factors has not yet fully understood. Prior epidemiological evidence of the causal relationship between the too is still argumentative. Various studies have been done using the same methods; yet, the outcomes were different. This study aimeds to conduct a meta-analysis to synthesize the results of recent studies in order to obtain accurate quantitative data. This systematic study followed the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guideline and studies published in the period of January 2010 to May 2020 were screened using the Cochrane Library, Ebsco, Medline/PubMed, ProQuest and Science Direct as the sources. Meta-analysis was conducted to synthesize the association between the SUA level and severity of coronary artery stenosis using random effect model to account for possible study heterogeneity. Heterogeneity was assessed using I2 and the meta-analysis was performed using Comprehensive Meta Analysis Version 3 (CMA3) software. Five studies (n = 601 subjects) identified a correlation between serum uric acid level and Gensini score (r = 0.548; p <0.001) in ACS patients. Heterogeneity bias was found in the analysis, whereas publication bias was not found. Thus, the severity of coronary artery stenosis in patients with ACS is positively correlated with serum uric acid level.

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The Co Relation of Serum Uric Acid with Risk Factors and Severity of Coronary Artery Disease (CAD) in Acute Coronary Syndrome

Cited by 3 publications

References 17 publications

Korelasi Kadar Asam Urat Serum dengan Keparahan Stenosis Arteri Koroner Pasien Sindrom Koroner Akut: Studi Meta-Analisis

Korelasi Kadar Asam Urat Serum dengan Keparahan Stenosis Arteri Koroner Pasien Sindrom Koroner Akut: Studi Meta-Analisis

Serum uric acid levels predict high hs-CRP levels in non-diabetic adult

Correlation between Serum Uric Acid Level and Severity of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome

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