The CLOCK 3111T/C SNP is associated with morning gastric motility in healthy young women

Yamaguchi, Mitsue; Kotani, Kazuhiko; Sakane, Naoki; Tsuzaki, Kokoro; Takagi, Atsutoshi; Wakisaka, Shiori; Moritani, Toshio; Nagai, Narumi

doi:10.1016/j.physbeh.2012.06.006

Cited by 6 publications

(12 citation statements)

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“…Accordingly, we have previously demonstrated the involvement of CLOCK on gut function; subjects with the CLOCK 3111T/C SNP showed slower gastric waves (mean, 2.45 cpm) compared to those with the T/T genotype (2.94 cpm) [ 16 ]. Given the existence of several circadian clock genes [ 6 – 8 ], the impact of other clock gene polymorphisms on gut function should further be investigated.…”

Section: Introductionmentioning

confidence: 99%

Circadian Rhythm Genes CLOCK and PER3 Polymorphisms and Morning Gastric Motility in Humans

et al. 2015

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BackgroundClock genes regulate circadian rhythm and are involved in various physiological processes, including digestion. We therefore investigated the association between the CLOCK 3111T/C single nucleotide polymorphism and the Period3 (PER3) variable-number tandem-repeat polymorphism (either 4 or 5 repeats 54 nt in length) with morning gastric motility.MethodsLifestyle questionnaires and anthropometric measurements were performed with 173 female volunteers (mean age, 19.4 years). Gastric motility, evaluated by electrogastrography (EGG), blood pressure, and heart rate levels were measured at 8:30 a.m. after an overnight fast. For gastric motility, the spectral powers (% normal power) and dominant frequency (DF, peak of the power spectrum) of the EGG were evaluated. The CLOCK and PER3 polymorphisms were determined by polymerase chain reaction (PCR) restriction fragment length polymorphism analysis.ResultsSubjects with the CLOCK C allele (T/C or C/C genotypes: n = 59) showed a significantly lower DF (mean, 2.56 cpm) than those with the T/T genotype (n = 114, 2.81 cpm, P < 0.05). Subjects with the longer PER3 allele (PER3 4/5 or PER3 5/5 genotypes: n = 65) also showed a significantly lower DF (2.55 cpm) than those with the shorter PER3 4/4 genotype (n = 108, 2.83 cpm, P < 0.05). Furthermore, subjects with both the T/C or C/C and PER3 4/5 or PER3 5/5 genotypes showed a significantly lower DF (2.43 cpm, P < 0.05) than subjects with other combinations of the alleles (T/T and PER3 4/4 genotype, T/C or C/C and PER3 4/4 genotypes, and T/T and PER3 4/5 or PER3 5/5 genotypes).ConclusionsThese results suggest that minor polymorphisms of the circadian rhythm genes CLOCK and PER3 may be associated with poor morning gastric motility, and may have a combinatorial effect. The present findings may offer a new viewpoint on the role of circadian rhythm genes on the peripheral circadian systems, including the time-keeping function of the gut.

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Section: Introductionmentioning

confidence: 99%

Circadian Rhythm Genes CLOCK and PER3 Polymorphisms and Morning Gastric Motility in Humans

et al. 2015

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“…Time differences cause resets in per2 gene expression in the intestinal tract, leading to intestinal dysfunctions including abdominal pain, constipation and diarrhea, which are the main causes and symptoms of IBS (58)(59)(60)(61)(62). With regards to intestinal functional regulation in the peripheral nervous system, the per2 gene is mainly expressed in the myenteric plexus of the intestinal tract, where neurotransmitters promoting intestinal movement are synthesized (8). The HPA axis plays an important regulatory role in intestinal movement.…”

Section: Irritable Bowel Syndrome (Ibs)mentioning

confidence: 99%

“…The per2 gene is expressed in the central and peripheral nervous systems and operates as a pacemaker of circadian rhythm in the brain of humans and other mammals, regulating spontaneous activity, metabolism and behavior. Rhythmic per2 expression is regulated by the SCN, but also, via negative feedback regulation from the bed nucleus of the stria terminalis (BNST) and the central nucleus of the amygdala (CeA) in the limbic system, as well as from corticosterone (6)(7)(8). Per2 is crucial for regulating visceral cyclic rhythmic activities through the HPA axis of the limbic system (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

“…Rhythmic per2 expression is regulated by the SCN, but also, via negative feedback regulation from the bed nucleus of the stria terminalis (BNST) and the central nucleus of the amygdala (CeA) in the limbic system, as well as from corticosterone (6)(7)(8). Per2 is crucial for regulating visceral cyclic rhythmic activities through the HPA axis of the limbic system (6)(7)(8). Current research has addressed the mechanism of action of PER2 on target organs, the HPA axis and the limbic system (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

“…Per2 is crucial for regulating visceral cyclic rhythmic activities through the HPA axis of the limbic system (6)(7)(8). Current research has addressed the mechanism of action of PER2 on target organs, the HPA axis and the limbic system (6)(7)(8). However, it remains poorly understood whether per2 is involved in regulatory mechanisms of the limbic system on lower-level brain structures.…”

Section: Introductionmentioning

confidence: 99%

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Research progress on the central mechanism underlying regulation of visceral biological rhythm by per2 (Review)

Zhu¹,

Yu²,

Zhang³

et al. 2014

Molecular Medicine Reports

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The period circadian clock 2 (per2) gene plays an important role in modulating the circadian rhythm in the central nervous system. Its protein product, PER2, is mainly expressed in the suprachiasmatic nucleus (SCN) and limbic system, including the central nucleus of the amygdala (CeA), the bed nucleus of the stria terminalis (BNST) and the hippocampus. PER2 rhythmic expression regulates hypothalamus‑pituitary‑adrenal (HPA) axis excitability and circadian rhythm via integration of optical signals and corticotropin‑releasing factor (CRF) stress‑related neurotransmitters, resulting in circadian rhythmicity in target organs. Moreover, glucocorticoids and glucocorticoid receptors exert strong negative feedback to the HPA axis and certain regions of the limbic system, modulating rhythmic per2 expression in peripheral organs. To date, the mechanism of action of PER2 in the limbic system and the HPA axis remains unclear, yet the per2 gene is considered valuable in clinical research for the study of metabolic syndromes, functional gastrointestinal disorders and certain liver diseases. In this review, we summarize the biological effects of the per2 gene and its protein product, PER2, in the limbic system, its involvement in regulation of the HPA axis by the limbic system and the resulting effects on the biological rhythm of target organs, and its clinical significance.

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Stem cell activation in skeletal muscle regeneration

Wang

2015

Cell. Mol. Life Sci.

126

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Muscle stem cell (satellite cell) activation post muscle injury is a transient and critical step in muscle regeneration. It is regulated by physiological cues, signaling molecules, and epigenetic regulatory factors. The mechanisms that coherently turn on the complex activation process shortly after trauma are just beginning to be illuminated. In this review, we will discuss the current knowledge of satellite cell activation regulation.

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The CLOCK 3111T/C SNP is associated with morning gastric motility in healthy young women

Cited by 6 publications

References 31 publications

Circadian Rhythm Genes CLOCK and PER3 Polymorphisms and Morning Gastric Motility in Humans

Circadian Rhythm Genes CLOCK and PER3 Polymorphisms and Morning Gastric Motility in Humans

Research progress on the central mechanism underlying regulation of visceral biological rhythm by per2 (Review)

Stem cell activation in skeletal muscle regeneration

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