The clinicopathological and genetic features of ovarian diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma and red cell autoimmunity: clinical role and pathogenesis

“…have also previously been identified in primary CNS lymphoma (109), primary gastrointestinal lymphoma (110) and ovarian and other extranodal DLBCL (111). The clinical significance of these mutations is currently unknown, but frequent non-frameshift insertions have previously been documented in NCOR2 in extranodal marginal zone lymphoma which were observed to reduce function (112).…”

Targeting Notch4 in Cancer: Molecular Mechanisms and Therapeutic Perspectives

“…Mutations and amplifications of the Notch4 gene, which partly lead to gain-of-function of Notch4 protein, have been frequently reported in human cancers. [11][12][13][14][15][16][17][18][19] To date, numerous studies have explored the roles of Notch4 in cancer, and especially its related molecular mechanisms. Most studies suggested that Notch4 is abnormally overexpressed during cancer development and is involved in the regulation of several tumorcell behaviors, mainly in stem cell-like self-renewal, epithelial-mesenchymal transition (EMT), radio-/chemo resistance and angiogenesis (See details in the following parts).…”

A Case of Ovary Diffuse Large B-cell Lymphoma

“…Most clinical show with pelvic masses and abdominal pain. The most common type is Diffuse Large B-cell Lymphoma (DLBCL), and the most DLBCL is the germinal center type [3]. Since the ovaries is not contain lymphoid tissue, the ovarian-derived lymphoma is controversial.…”