The clinical use of pretreatment NLR, PLR, and LMR in patients with esophageal squamous cell carcinoma: evidence from a meta-analysis

Sun, Yugui; Zhang, Lifei

doi:10.2147/cmar.s171035

Cited by 88 publications

(94 citation statements)

References 43 publications

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“…Nevertheless, the PLOS ONE bulk of literature have described that the higher LMR was a negative factor for the prognosis of diseases, such as gastric cancer [30] and early-stage Hodgkin lymphoma [31]. But a meta analysis study has suggested that the low LMR was associated with the poor outcome for patients with esophageal squamous cell carcinoma [32]. The results of the association of maternal LMR and pregnancy outcome is not exactly consistent with some studies.…”

Section: Discussionmentioning

confidence: 87%

The benefits of higher LMR for early threatened abortion: A retrospective cohort study

Feng

Chen

et al. 2020

PLoS ONE

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To investigate the relation of inflammation-related parameters and pregnancy outcome in women with the early threatened abortion. Method of study 630 women with early threatened abortion were divided into two groups based on the pregnancy outcome. All of them had the blood routine examination before treating. The differences between two groups were analyzed by the Chi-squared test, Student T test, Mann-Whitney U test, Binary Logistic Regression, Marginal Structural Model and Threshold effect analysis. Results We found that there is no significant difference in the pregnancy outcome for NLR (OR:0.92, CI95%:0.72, 1.17) and PLR (OR:1.00, CI%:0.99, 1.01). However, a difference had a statistical significance in the pregnancy outcome when LMR less than 2.19 (OR:0.39, CI95%:0.19,0.82). Conclusions This study suggested that higher LMR was related to the lower risk of miscarriage in the women with early threatened abortion in a way.

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Section: Discussionmentioning

confidence: 87%

The benefits of higher LMR for early threatened abortion: A retrospective cohort study

Feng

Chen

et al. 2020

PLoS ONE

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“…The NLR was defined as the absolute neutrophil count divided by the absolute lymphocyte count within 2 weeks before the initial treatment. [4][5][6][7][8][9][10][11][12][13][14] The cutoff value calculated from the ROC curve, mean, tertile, or median in previous studies varied from 1.98-5; 4-11 thus, the standard cutoff value remains unknown. In the current study, the cutoff value was defined as the mean value of the NLR.…”

Section: Methodsmentioning

confidence: 99%

“…[1][2][3] The peripheral neutrophil-to-lymphocyte ratio (NLR) is a well-known inflammatory marker. Several authors have previously reported that a high NLR is significantly associated with poor survival in solid cancers, [4][5][6][7][8][9][10][11][12][13][14] including head and neck squamous cell carcinoma and breast cancer. However, whether the NLR affects prognosis in patients with parotid cancer remains unknown; therefore, the current study aimed to clarify this question.…”

Section: Introductionmentioning

confidence: 99%

<p>Role of the pretreatment neutrophil-to-lymphocyte ratio in the survival of primary parotid cancer patients</p>

Cheng

Liu

Niu

et al. 2019

CMAR

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Background: To analyze the value of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in the survival of patients with parotid cancer. Methods: In total, 249 patients were enrolled. Information including age, sex, pretreatment NLR, and pathologic variables such as, tumor stage, intraparotid node (IPN) metastasis, and follow-up findings was extracted and analyzed. Results: IPN metastasis was noted in 45 (18.1%) patients, and the mean NLR was 2.48, with a range from 1.5 to 6.1. The NLR was significantly associated with tumor stage, disease stage, and disease grade. A total of 73 patients died of the disease, and the 10-year disease-specific survival (DSS) rate was 62%. In patients with an NLR<2.48, the 10-year DSS rate was 68%; in patients with an NLR≥2.48, the 10-year DSS rate was 58%, and the difference was significant (P=0.006). Cox model analysis showed that the NLR was an independent prognostic factor for DSS. Conclusion: The long-term survival of primary parotid cancer patients is relatively favorable, and the pretreatment NLR is significantly associated with prognosis.

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“…Therefore, in the current situation of the lack of more reliable tumor prognostic indicators, NLR and PLR may provide information on patient prognosis. It is currently known that NLR and/or PLR may be associated with a variety of tumor prognosis, including non-digestive tumor NSCLC (37), breast cancer (38), ovarian cancer (39), Hodgkin lymphoma (40), prostate cancer (41), cervical cancer (42), nasopharyngeal carcinoma (28), and tumors of the digestive tract such as esophageal squamous cell carcinoma (43,44), gastric cancer (45), pancreatic cancer (46), and colorectal cancer (47).…”

Section: Discussionmentioning

confidence: 99%

Preoperative Neutrophil Lymphocyte Ratio Can Be Used as a Predictor of Prognosis in Patients With Adenocarcinoma of the Esophagogastric Junction: A Systematic Review and Meta Analysis

et al. 2020

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Objective: Neutrophil lymphocyte ratio (NLR), Lymphocyte mononuclear cell ratio (LMR), and Platelet lymphocyte ratio (PLR) can be used as various prognostic factors for malignant tumors, but the value of prognosis for patients with adenocarcinoma of the esophagogastric junction (AEG) has not been determined. This study used meta-analysis to assess the value of these indicators in the evaluation of AEG prognosis. Methods: Relevant literatures on the prognostic relationship between NLR, LMR, PLR, and AEG was retrieved from PubMed, Web of Science, Embase, Cochrane Library, Cochrane Central Register of Controlled Trials, Wanfang data, and Chinese National Knowledge Infrastructure. The search time from database establishment to June 30, 2019. The language is limited to English and Chinese. Data was analyzed using Stata 15.0 software. Result: Six retrospective studies were included, five of them involved NLR and six of them involved PLR. No LMR literature that adequately satisfied the conditions was retrieved. Increased NLR was significantly associated with a significant reduction in overall survival (OS), cancer-specific survival (CSS), or disease specific survival (DSS) in patients with AEG [hazard ratio (HR) = 1.545, 95% CI: 1.096-2.179, P < 0.05]. Subgroup analysis showed that NLR had significant value in the prognosis of both Chinese and Non-Chinese patients (P = 0.009 vs. P = 0.000). NLR had significant prognostic value for ≥3 and <3 groups (P = 0.022 vs. P = 0.000). NLR has a significant prognostic value for samples ≥500 and <500 (P = 0.000 vs. P = 0.022). NLR and OS/CSS/DSS single factor meta-regression showed that regional NLR cutoff values and sample size may be the source of heterogeneity in AEG patients (all P < 0.05). There was no significant association between elevated PLR and OS in patients with AEG (HR = 1.117, 95% CI: 0.960-1.300, P > 0.05). PLR had no significant prognostic value for both Chinese and Liu et al. NLR Can Be Used as a Predictor of AEG UK patients (P = 0.282 vs. P = 0.429). PLR had no significant prognostic value for ≥150 group and <150 group (P = 0.141 and P = 0.724). No significant prognostic value was found in either the 300 group and <300 group (P = 0.282 vs. P = 0.429). Conclusion: Preoperative NLR rise was an adverse prognostic indicator of AEG. High-risk patients should be treated promptly. The results showed that PLR was not recommended as a prognostic indicator of AEG.

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The clinical use of pretreatment NLR, PLR, and LMR in patients with esophageal squamous cell carcinoma: evidence from a meta-analysis

Cited by 88 publications

References 43 publications

The benefits of higher LMR for early threatened abortion: A retrospective cohort study

The benefits of higher LMR for early threatened abortion: A retrospective cohort study

<p>Role of the pretreatment neutrophil-to-lymphocyte ratio in the survival of primary parotid cancer patients</p>

Preoperative Neutrophil Lymphocyte Ratio Can Be Used as a Predictor of Prognosis in Patients With Adenocarcinoma of the Esophagogastric Junction: A Systematic Review and Meta Analysis

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