The Clinical Syndrome of Phosphate Depletion

Massry, Shaul G.

doi:10.1007/978-1-4684-7758-0_32

Cited by 19 publications

(6 citation statements)

References 37 publications

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“…This may cause influx of phosphorus from the extracellular to the intracellular compartments. 31,32 In this study, the prevalence of hypophosphatemia in patients with chronic asthma was found, unexpectedly, to be high (15%); however, there was no previous study to compare our results with others. Hypophosphatemia can cause myocardial depression, respiratory muscle fatigue, and reduction of tissue oxygen extraction in patients with acute asthma and with COPD.…”

Section: Discussioncontrasting

confidence: 50%

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Electrolyte Disturbances in Patients With Chronic, Stable Asthma

Alamoudi

2001

Chest

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Section: Discussioncontrasting

confidence: 50%

“…8,10 In addition, corticosteroids increase urinary phosphorus excretion. 31,32 In acute asthma, the adrenaline and insulin levels were increased, secondary to ␤ 2 -agonist stimulation. This may cause influx of phosphorus from the extracellular to the intracellular compartments.…”

Section: Discussionmentioning

confidence: 99%

Electrolyte Disturbances in Patients With Chronic, Stable Asthma

Alamoudi

2001

Chest

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“…The authors concluded that dietary phosphate depletion increased cytosolic Ca 2þ levels and decreased ATP concentration of granulocytes, which, in turn, resulted in an impaired phagocytic activity (92) . Similarly, Massry (101) observed elevated cytosolic Ca 2þ levels and an impaired phagocytosis of granulocytes in rats fed a low-P diet. In a study with dairy cows, Mullarky et al (91) found no effect of dietary P supply on the bactericidal activity of neutrophils against Staphylococcus aureus.…”

Section: Activity Of Phagocytesmentioning

confidence: 80%

The impact of phosphorus on the immune system and the intestinal microbiota with special focus on the pig

et al. 2015

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There is increasing interest in dietary ingredients that are appropriate to support digestive and immune functions, but also maintain a stable microbial ecosystem in the gastrointestinal tract (GIT), particularly in weaned pigs. P is an essential nutrient for both microbes and their host, as it is involved, for example, in bone formation, energy metabolism, cellular signalling and stabilisation of cell membranes. Non-ruminant animals have limited access to phytate, the main storage form of P in plant seeds. The release of P bound to phytate requires phytase activity of plant or microbial origin, resulting in the formation of variable phosphorylated inositol phosphates (InsPs). The present review focuses on interactions between variations in dietary P supply, the immune system of the host, and the intestinal microbial ecosystem. Although results on the interaction between P and the immune system are inconsistent, several studies in different species have shown a positive impact of dietary P and phytase addition on the adaptive immune response. Recent studies with pigs suggest that P supply may influence intestinal microbial composition and activity. Individual InsPs or phosphate may also affect properties of pathogenic micro-organisms, such as metabolism or virulence. In conclusion, P may be considered as part of an integrated approach to support immune functions and maintain a stable microbial ecosystem in the GIT, thereby providing a barrier against potential pathogens. Within this regard, differences in phytate-P content and intrinsic phytase activity of plant feedstuffs, as well as the formation of individual InsPs, have to be taken into account.

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“…Massry has shown the clinical syndrome of phosphate depletion. According to Massry's study on phosphate depletion, the syndrome can lead to disturbances in the central nervous system, hematopoietic system, parathyroid glands, cardiac function, renal function, and also in muscles and bones [15]. The low levels of phosphorus affect the organs; a decrease in 2,3-diphosphoglycerate in red blood cells leads to tissue hypoxia, mitochondrial energy production decreases due to low tissue content of ATP.…”

Section: Discussionmentioning

confidence: 99%

Low Serum Phosphorus Levels and Acute Ischemic Stroke

Sönmezler¹,

KeÅkek²

2019

J Intensive & Crit Care

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Objective: The aim of this study was to investigate the relationship between the mortality and serum phosphorus levels in patients with acute ischemic stroke. Methods: The data of 86 patients admitted to the study were analysed retrospectively. Results: A total of 86 patients (n:86) with acute ischemic stroke who were followed up in our hospital Neurology Intensive Care Unit (NICU). Fifty of 86 patients were survived and transferred to our service, then discharged. The number of patients who died was 36. The mean level of serum phosphorus of patients who died (2.77 ± 0.39) was significantly lower than that of the living patients (3.14 ± 0.20) (p<0.001). Conclusions: This study supports that low serum phosphorus level is associated with mortality in patients with acute ischemic stroke.

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The Clinical Syndrome of Phosphate Depletion

Cited by 19 publications

References 37 publications

Electrolyte Disturbances in Patients With Chronic, Stable Asthma

Electrolyte Disturbances in Patients With Chronic, Stable Asthma

The impact of phosphorus on the immune system and the intestinal microbiota with special focus on the pig

Low Serum Phosphorus Levels and Acute Ischemic Stroke

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