The clinical significance of wrist fracture in osteoporosis

Cerocchi, Irene; Ghera, S; Gasbarra, Elena; Feola, Maurizio; Tarantino, Umberto

doi:10.1007/s40520-013-0083-0

Cited by 9 publications

(12 citation statements)

References 8 publications

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“…[1] Most wrist fractures occur in women, with the highest incidence between ages 40 and 60 years. [2, 3] Studies have shown that a wrist fracture history increases the risk for subsequent fragility fractures. For example, the Women’s Health Initiative reported that a wrist fracture history increased the risk for a subsequent fracture by 37% for any fracture and as much as 80% for any non-wrist upper extremity fracture.…”

Section: Introductionmentioning

confidence: 99%

The epidemiology of wrist fractures in older men: the Osteoporotic Fractures in Men (MrOS) study

et al. 2018

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Section: Introductionmentioning

confidence: 99%

The epidemiology of wrist fractures in older men: the Osteoporotic Fractures in Men (MrOS) study

et al. 2018

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“…Wrist fractures are the most common type of clinical fracture among U.S. women aged less than 65 years (7,8) . Moreover, wrist fractures are associated with functional decline (9) .…”

Section: Introductionmentioning

confidence: 99%

“…(1)(2)(3)(4)(5)(6) Wrist fractures are the most common type of clinical fracture among US women aged younger than 65 years. (7,8) Moreover, wrist fractures are associated with functional decline. (9) In the 5 years after a distal forearm fracture, the risk of mortality ranges from 12% among women aged 65 and 74 years to 43% for women aged 85þ.…”

Section: Introductionmentioning

confidence: 99%

Wrist Fracture and Risk of Subsequent Fracture: Findings from the Women's Health Initiative Study

Crandall

Hovey

Cauley

et al. 2015

Journal of Bone and Mineral Research

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Wrist fractures are common in postmenopausal women and are associated with functional decline. Fracture patterns after wrist fracture are unclear. The goal of this study was to determine the frequency and types of fractures that occur after a wrist fracture among postmenopausal women. We carried out a post-hoc analysis of data from the Women’s Health Initiative Observational Study and Clinical Trials (1993–2010) carried out at 40 U.S. clinical centers. Participants were postmenopausal women aged 50–79 at baseline. Mean follow-up duration was 11.8 years. Main measures included incident wrist, clinical spine, humerus, upper extremity, lower extremity, hip, and total non-wrist fractures and bone mineral density (BMD) in a subset. Among women who experienced wrist fracture, 15.5% subsequently experienced non-wrist fracture. The hazard for non-wrist fractures was higher among women who had experienced previous wrist fracture than among women who had not experienced wrist fracture: non-wrist fracture overall (hazard ratio [HR] 1.40, 95% confidence interval [CI] 1.33–1.48), spine (HR 1.48, 95% CI 1.32–1.66), humerus (HR 1.78, 95% CI 1.57–2.02), upper extremity (non-wrist) (HR 1.88, 95% CI 1.70–2.07), lower extremity (non-hip) (HR 1.36, 95% CI 1.26–1.48), and hip (HR 1.50, 95% CI 1.32–1.71) fracture. Associations persisted after adjustment for BMD, physical activity, and other risk factors. Risk of non-wrist fracture was higher in women who were younger when they experienced wrist fracture (interaction p-value 0.02). Associations between incident wrist fracture and subsequent non-wrist fracture did not vary by baseline BMD category (normal, low bone density, osteoporosis). A wrist fracture is associated with increased risk of subsequent hip, vertebral, upper extremity, and lower extremity fractures. There may be substantial missed opportunity for intervention in the large number of women who present with wrist fractures.

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“…Osteoporosis, the most common metabolic bone disease of the elderly, presents with decreased bone mass and increased occurrence of fragility fractures 1 . These fractures are one of the most important problem in the elderly population, leading to significant increase of cost to health care service [2][3][4] . Recent and contradictory data are reported about the possible role of PTX3 in bone homeostasis.…”

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confidence: 99%