The clinical significance of the prognostic nutritional index in very elderly patients over 80 years of age with diffuse large B-cell lymphoma

Hamada, Erina; Ogura, Shinji; Nishiyama‐Fujita, Yuriko; Akiimoto, Masahiro; Tanigawa, Tomohiko; Ito, Chisako; Sakurai, Aki; Aisa, Yoshinobu; Nakazato, Tomonori

doi:10.1007/s00277-020-04012-7

Cited by 6 publications

(5 citation statements)

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“…Out of the 7 chosen studies that were published from 2016 to 2020, 4 were conducted in China [ 15−17 , 19 ], while the remaining 3 were each carried out in Korea [ 18 ], Japan [ 20 ] and Croatia [ 22 ], respectively. In terms of language, 6 studies were published in English [ 15 , 16 , 18 – 20 , 22 ] and 1 in Chinese [ 17 ]. The total sample size was 1311, and the cut-off values of PNI were between 40 and 45.…”

Section: Resultsmentioning

confidence: 99%

“…The total sample size was 1311, and the cut-off values of PNI were between 40 and 45. Whilst R-CHOP or R-CHOP like regimen was employed in 3 studies [ 18 , 19 , 22 ]; R-CHOP/CHOP or CHOP like regimen was used in another 3 studies [ 15 – 17 ]; whereas rituximab-containing chemotherapy regimens (R-CHOP /R-CVP/rituximab alone) and palliative therapy were used in the remaining study [ 20 ]. The prognostic values of PNI on OS [ 15−20 , 22 ] were reported in all 7 studies; while the association between PNI and PFS [ 15 , 16 , 18 , 22 ] was shown in 4 studies.…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies have revealed that PNI exhibit a prognostic value for DLBCL patients [ 15−20 , 22 ]. However, whilst most studies [ 15 , 17 , 18 , 20 , 22 ] have demonstrated PNI as a significant prognostic factor for DLBCL patients; two studies have reported the opposite results [ 16 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have found that PNI, an indicator that reflects the nutritional and immune status of patients, can be used to predict the clinical outcomes of patients with various malignant tumors, regardless of the tumor location and origin [ 10 – 14 ]. Some studies have focused on exploring the prognostic value of PNI for DLBCL, however the results were inconsistent and contradictory [ 3 , 15 – 20 ], possibly due to small sample sizes and patient heterogeneity in individual studies. In order to achieve a comprehensive evaluation of PNI for DLBCL, we aggregated the data from related studies and performed a meta-analysis to investigate how PNI is used in predicting the OS and the progression-free survival (PFS) of patients.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic nutritional index and the prognosis of diffuse large b-cell lymphoma: a meta-analysis

et al. 2020

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Background Some studies have investigated the prognostic value exhibited by the Prognostic Nutritional Index (PNI) in patients suffering diffuse large B-cell lymphoma (DLBCL), but varying results were obtained. In order to determine the specific prognostic value more accurately, a meta-analysis was conducted in this study. Methods Literatures were searched from the China National Knowledge Infrastructure (CNKI), Wanfang, PubMed, Embase, the Cochrane Library, and Web of Science. Pooled hazard ratio (HR) and the 95% confidence interval (CI) were calculated to assess the association between PNI and the overall survival (OS) and the progression-free survival (PFS) of patients with DLBCL. Results Based on seven studies with a total number of 1311 patients, our meta-analysis revealed that low PNI may meant poor OS (HR = 2.14, 95% CI 1.66–2.75, p < 0.001) and poor PFS (HR = 1.75, 95% CI 1.36–2.25, p = 0.438). Subgroup analysis showed that, in Asians, low PNI was correlated to poor OS (pooled HR = 2.06 95% CI 1.59–2.66) and poor PFS (pooled HR = 1.66, 95% CI 1.28–2.15). Similar results were obtained from one European study, which is the only study performed outside of Asia from our literature search. Conclusion For patients with DLBCL, low PNI may be interpreted as adverse prognosis. More data from European patients are required in this study to avoid analysis bias.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic nutritional index and the prognosis of diffuse large b-cell lymphoma: a meta-analysis

et al. 2020

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“…Numerous studies have highlighted the impact of nutritional status on the prognosis of DLBCL, particularly in older patients [4,[16][17][18][19][20][21][22]. Nutritional and inflammatory status (NIS) [23], a score based on albumin, prealbumin, and two markers of inflammation, namely, C-reactive protein (CRP) and alpha-1 acid glycoprotein, was associated with toxicity following chemotherapy in patients with cancer [24] and with overall survival (OS) in metastatic breast cancer [25].…”

Section: Introductionmentioning

confidence: 99%

Prognostic relevance of sarcopenia, geriatric, and nutritional assessments in older patients with diffuse large B-cell lymphoma: results of a multicentric prospective cohort study

et al. 2023

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This prospective study aimed to investigate the prognostic effect of sarcopenia, geriatric, and nutritional status in older patients with diffuse large B-cell lymphoma (DLBCL). Ninety-five patients with DLBCL older than 70 years who were treated with immunochemotherapy were included. The lumbar L3 skeletal muscle index (L3-SMI) was measured by computed tomography at baseline, and sarcopenia was defined as low L3-SMI. Geriatric assessment included G8 score, CIRS-G scale, Timed Up and Go test, and instrumental activity of daily living. Nutritional status was assessed using the Mini Nutritional Assessment and the body mass index, and several scores used in the literature incorporating nutritional and inflammatory biomarkers, namely the Nutritional and inflammatory status (NIS), Geriatric Nutritional Risk Index, Prognostic Nutritional Index, and Glasgow Prognostic Score.Fifty-three patients were considered sarcopenic. Sarcopenic patients displayed higher levels of inflammation markers and lower levels of prealbumin than non-sarcopenic patients. Sarcopenia was associated with NIS, but was not associated with severe adverse events and treatment disruptions. They were, however, more frequent among patients with elevated NIS. Sarcopenia did not appear in this study as a prognostic factor for progression-free survival (PFS) or overall survival (OS). However, NIS emerged as predictive of the outcome with a 2-year PFS rate of 88% in the NIS ≤ 1 group and 49% in the NIS > 1 group and a significant effect in a multivariate analysis for both PFS (p = 0.049) and OS (HR = 9.61, CI 95% = [1.03–89.66], p = 0.04). Sarcopenia was not associated with adverse outcomes, but was related to NIS, which appeared to be an independent prognostic factor.

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Validation and comparison of prognostic values of GNRI, PNI, and CONUT in newly diagnosed diffuse large B cell lymphoma

Matsukawa

Suto

Kanaya³

et al. 2020

Ann Hematol

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The clinical significance of the prognostic nutritional index in very elderly patients over 80 years of age with diffuse large B-cell lymphoma

Cited by 6 publications

References 3 publications

Prognostic nutritional index and the prognosis of diffuse large b-cell lymphoma: a meta-analysis

Prognostic nutritional index and the prognosis of diffuse large b-cell lymphoma: a meta-analysis

Prognostic relevance of sarcopenia, geriatric, and nutritional assessments in older patients with diffuse large B-cell lymphoma: results of a multicentric prospective cohort study

Validation and comparison of prognostic values of GNRI, PNI, and CONUT in newly diagnosed diffuse large B cell lymphoma

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