Validation and comparison of prognostic values of GNRI, PNI, and CONUT in newly diagnosed diffuse large B cell lymphoma

Matsukawa, Toshihiro; Suto, Keito; Kanaya, Minoru; Izumiyama, Koh; Minauchi, Koichiro; Yoshida, Shota; Oda, Hideaki; Miyagishima, Takuto; Mori, Akio; Ota, Shuichi; Hashimoto, Daigo; Teshima, Takanori

doi:10.1007/s00277-020-04262-5

Cited by 38 publications

(48 citation statements)

References 36 publications

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“…Poor nutritional status is correlated with the toxicity of chemotherapy, resulting in treatment reduction or interruption 17 . The present ndings were consistent with previous reports in other hematological malignancies, which showed the signi cant prognostic utility of the CONUT score in adult T-cell leukemia/lymphoma (ATLL) 11 , DLBCL 12,13 , multiple myeloma 14,15 , myelodysplastic syndrome (MDS), and acute myeloid leukemia (AML) 16 . This study is the rst to con rm the prognostic impact of the CONUT score in patients with PTCL.…”

Section: Discussionsupporting

confidence: 93%

“…The median age at diagnosis was 67 (range 16-87) years, and the most common pathological diagnosis was PTCL not otherwise speci ed (PTCL-NOS) (n = 65), followed by angioimmunoblastic T-cell lymphoma (AITL) (n = 13) and anaplastic large cell lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) (n = 10). The median CONUT score was 3 (0-12), and nutritional status was normal (0-1), mild (2-4), moderate (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), and severe (9-12) in 16 (16.2%), 45 (45.5%), 23 (23.3%), and 15 (15.2%) patients, respectively. Forty-four patients (44.4%) received CHOP, 43 patients (43.4%) received THP-COP (CPA, tetrahydropyranyl adriamycin, VCR, OSL), and 10 patients (10.1%) received best supportive care (BSC).…”

Section: Patients' Characteristicsmentioning

confidence: 99%

“…Several cohort studies have reported that the CONUT score is an independent prognostic factor in solid cancer patients 10 . In several haematological malignancies, including B-cell lymphoma, leukemia, and myeloma [11][12][13][14][15][16] , the CONUT score provided useful prognostic information. However, it remains unclear whether nutritional status has a clinical impact in patients with PTCL.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Impact of the Controlling Nutrition Status Score in Patients With Peripheral T-cell Lymphoma

Nakamura

Kanemura

Lee

et al. 2021

Preprint

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The controlling nutritional status (CONUT) is a simplified nutritional index calculated from serum albumin, total cholesterol, and the total lymphocyte count. Although the CONUT score is an independent prognostic factor in several hematological malignancies, the prognostic impact of the CONUT score in peripheral T-cell lymphoma (PTCL) is unclear. This study evaluated the prognostic impact of the CONUT score on overall survival (OS) in patients with PTCL. A multicentre, retrospective, cohort study including 99 patients with PTCL was conducted. The CONUT score was significantly higher in the non-survivor group (median 5, range 0-12) than in the survivor group (median 3, range 0-11) (P = 0.026). The CONUT score was an independent prognostic factor in a multivariable Cox proportional hazards model (hazard ratio 1.118, 95% confidence interval 1.020-1.225, P = 0.017). The Cox proportional hazards model with restricted cubic spline showed an S-shaped relationship between the CONUT score and OS. No significant effect-modification by the International Prognostic Index (IPI) was observed, and the CONUT score affected the prognosis of PTCL regardless of the IPI (P for interaction = 0.208). In conclusion, the CONUT score is an independent prognostic factor in patients with PTCL irrespective of IPI categories.

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Section: Discussionsupporting

confidence: 93%

Section: Patients' Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic Impact of the Controlling Nutrition Status Score in Patients With Peripheral T-cell Lymphoma

Nakamura

Kanemura

Lee

et al. 2021

Preprint

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“…There are a limited number of studies showing the effect of CONUT score in haematological [20,21]. We also evaluated the difference of CONUT score with prognostic factors.…”

Section: Discussionmentioning

confidence: 99%

Is CONUT score a prognostic index in patients with diffuse large cell lymphoma?

G¹,

Hacioglu²,

B³

et al. 2021

Turk J Med Sci

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Background/Aim: The aim of the study was to evaluate the effect of Controlling Nutritional Status (CONUT) score on the prognosis in patients with diffuse large B-cell lymphoma(DLBCL). Materials and Methods:The present study was a retrospective study. The CONUT score was calculated based on serum albumin, total cholesterol and lymphocyte levels. This study included a total of 266 patients, 131(49.2%) were female and 135(50.8%) were male. The median follow-up period was 51 months (range: 1-190). Results:The median age was 64 years. The cut off CONUT was 1.5. There was a significant difference between patients with high (≥2) or low (<2) CONUT scores in terms of overall survival(OS) and progression-free survival(PFS). The 5-year OS and PFS in patients with high CONUT score was 52.1% and 49.7%. The 5-year OS and PFS in patients with low CONUT score was 79.8% and 75.6% (p<0.001). In the multivariate analysis for OS, age ≥65 years (HR=1.80, p=0.028), Eastern Cooperative Oncology Group (ECOG) >1 (HR=2.04, p=0.006), stage IIIA-IVB disease (HR=2.75, p=0.001) and the CONUT score (HR=1.15, p = 0.003) were found statistically significant. In the multivariate analysis for PFS, age ≥65 years (HR=2.02, p=0.007), stage IIIA-IVB disease (HR=2.42, p=0.002) and the CONUT score (HR=1.19, p=0.001) were found to be significant parameters. Conclusion:High CONUT score reduces OS and PFS in DLBCL. CONUT score is an independent, strong prognostic index in patients with DLBCL.

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“…Several nutritional indices are currently in use: the neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, the modi ed Glasgow prognostic score, the prognostic nutritional index, the controlling nutritional status score, sarcopenia, and the geriatric nutritional index (GNRI). Some researchers have suggested that these indices can predict not only postoperative complications but also the long-term outcomes of several cancers [3][4][5] . Therefore, these nutritional scores are also considered to be useful for evaluating the postoperative complications and prognosis of HCC [6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

Geriatric Nutritional Risk Index Predicts Prognosis in Hepatocellular Carcinoma After Hepatectomy: A Propensity Score Matching Analysis

Kanno

Goto

SASAKI

et al. 2021

Preprint

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The geriatric nutritional risk index (GNRI) is widely used for nutritional assessment in older inpatients and was recently reported to be associated with postoperative complications and cancer prognosis. We investigated the use of the GNRI to predict long-term outcomes in hepatocellular carcinoma of all etiologies after hepatectomy. 358 patients were reviewed after propensity score matching. We dichotomized the GNRI score into high GNRI (> 98: N = 179) and low GNRI (≤ 98: N = 179) and evaluated recurrence-free survival (RFS) and overall survival (OS) between the two groups. Clinicopathological characteristics between the low- and high-GNRI groups were similar after propensity score matching except for the components of the GNRI score (body mass index and serum albumin level), Child–Pugh score (consisting serum albumin level), and preoperative alpha-fetoprotein level (p < .0001, p < .0001, p = 0.0060, and p = 0.0049, respectively). A high GNRI was associated with significantly better RFS and OS (p = 0.0001 and p = 0.0055, respectively; log-rank test). Multivariate analysis revealed that GNRI is an independent prognostic factor of RFS and OS (low vs. high; HR, 1.8670; 95%CI, 1.4011–2.4880; p < .0001, HR, 1.7270; 95% CI, 1.1640–2.5623; p = 0.0066, respectively). The GNRI is an objective, inexpensive, and easily calculated assessment tool for nutritional status and can predict prognosis in hepatocellular carcinoma after hepatectomy.

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Validation and comparison of prognostic values of GNRI, PNI, and CONUT in newly diagnosed diffuse large B cell lymphoma

Cited by 38 publications

References 36 publications

Prognostic Impact of the Controlling Nutrition Status Score in Patients With Peripheral T-cell Lymphoma

Prognostic Impact of the Controlling Nutrition Status Score in Patients With Peripheral T-cell Lymphoma

Is CONUT score a prognostic index in patients with diffuse large cell lymphoma?

Geriatric Nutritional Risk Index Predicts Prognosis in Hepatocellular Carcinoma After Hepatectomy: A Propensity Score Matching Analysis

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