The clinical significance of systemic inflammation score in esophageal squamous cell carcinoma

Han, Lihui; Song, Qingxu; Jia, Yibin; Chen, Xuan; Chen, Pengxiang; Min, Rui; Cheng, Yufeng

doi:10.1007/s13277-015-4152-1

Cited by 32 publications

(26 citation statements)

References 32 publications

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“…However, there is some controversy regarding the PNI in oesophageal cancer research. Han et al [22] retrospectively analysed 206 patients with ESCC after esophagectomy and found that a high PNI had a positive effect on OS in patients with ECSS, but the PNI was not found to be an independent prognostic factor, which was not consistent with our finding that the PNI was significantly associated with the OS (P = 0.002) and therefore the prognosis of oesophageal cancer. Our multivariate analysis also showed that multiple variables were significantly associated with OS in oesophageal cancer, which was similar to the findings of Sun et al [23].…”

Section: Discussioncontrasting

confidence: 87%

Clinical application value of the prognostic nutritional index for predicting survival in patients with oesophageal squamous cell carcinoma undergoing chemoradiotherapy or radiotherapy

Xiao

Lyu

Liu

et al. 2020

Preprint

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Background : The prognostic nutrition index (PNI) has been shown to have prognostic value for several common cancers. The study aim was to explore the clinical application value of the PNI for prognosis of patients with oesophageal squamous cell carcinoma (ESCC) treated with radical chemoradiotherapy (CRT) or radiotherapy (RT). Methods : Overall, 193 patients with ESCC who received radiotherapy with or without chemotherapy at Sichuan Cancer Hospital from March 20, 2012 to December 25, 2017 were retrospectively analysed. Based on serum measurements before treatment, the PNI at ESCC recurrence was calculated as albumin (g/L) + 5 × total lymphocyte count. The Kaplan–Meier method and Cox proportional regression model were used to analyse the relationship between PNI and overall survival (OS). Results : The average pretreatment PNI of 193 ESCC patients was 49.01 ± 4.68. The optimal cutoff value of PNI was 47.975, and the patients were divided into a low-PNI group (<47.975) and a high-PNI group (≥47.975). PNI was related to tumour length, T-stage and synchronous chemotherapy in ESCC patients (P < 0.05). The median OS for the entire group was 22.37 months. The median OS of patients in the high-PNI group and low-PNI group were 32.63 months and 15.4 months, respectively, the 3-year survival rates were 47.5% and 32.2% and the 5-year survival rates were 37.7% and 16.8%, respectively, (all P = 0.001). Univariate analysis showed that PNI, tumour length, T-stage and synchronous chemotherapy were related to the prognosis of ESCC patients (P < 0.05). Multivariate analysis showed that tumour length (P = 0.019), synchronous chemotherapy (P = 0.009) and PNI (P = 0.003) were independent prognostic factors affecting the prognosis of patients in ESCC treated with RT or CRT. Conclusions: The calculation of PNI value is simple, reliable and repeatable and can improve the accuracy of a patient’s prognosis. Confirmation of these results by a large-sample prospective study is desirable.

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Section: Discussioncontrasting

confidence: 87%

Clinical application value of the prognostic nutritional index for predicting survival in patients with oesophageal squamous cell carcinoma undergoing chemoradiotherapy or radiotherapy

Xiao

Lyu

Liu

et al. 2020

Preprint

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“…Freeing the oesophagus from the pericardium increases the risk of left atrium‐related complications. Oesophagectomy is also associated with a high risk of morbidity that elicits a potent inflammatory response. Inflammatory mediators released in the circulation after surgery increase the chance of AF through alterations in the expression of sodium and calcium channels in atria.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of risk factors and complications associated with atrial fibrillation after oesophagectomy

Schizas

Kosmopoulos

Giannopoulos

et al. 2019

British Journal of Surgery

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Background: Oesophagectomy is associated with high morbidity and mortality rates. New-onset atrial fibrillation (AF) is a frequent complication following oesophagectomy. Several studies have explored whether new-onset AF is associated with adverse events after oesophagectomy.Methods: This review was performed according to PRISMA guidelines. Eligible studies were identified through a search of PubMed, Scopus and Cochrane CENTRAL databases up to 25 November 2018. A meta-analysis was conducted with the use of random-effects modelling. The I 2 statistic was used to assess for heterogeneity.Results: In total, 53 studies including 9087 patients were eligible for analysis. The overall incidence of postoperative AF was 16⋅5 per cent. Coronary artery disease and hypertension were associated with AF, whereas diabetes, smoking and chronic obstructive pulmonary disease were not. Patients with AF had a significantly higher risk of overall postoperative adverse events than those without fibrillation (odds ratio (OR) 5⋅50, 95 per cent c.i. 3⋅51 to 8⋅30), including 30-day mortality (OR 2⋅49, 1⋅70 to 3⋅64), anastomotic leak (OR 2⋅65, 1⋅53 to 4⋅59) and pneumonia (OR 3⋅42, 2⋅39 to 4⋅90).Conclusion: Postoperative AF is frequently observed in patients undergoing oesophagectomy for cancer. It is associated with an increased risk of death and postoperative complications.

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“…First, the immunosuppressive effects of a prolonged severe illness may allow micrometastatic disease to flourish into a clinically relevant recurrence more rapidly than it would otherwise. Infectious complications after oesophagogastric surgery have been reported to produce a proinflammatory cytokine (interleukins 6 and 8)‐mediated response, which may also promote tumour progression after oesophagectomy. Second, the prolonged period needed to recover from this severe illness frequently precludes adjuvant chemotherapy, which has been shown to confer a significant survival benefit in responders to neoadjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Impact of postoperative complications on disease recurrence and long-term survival following oesophagogastric cancer resection

Saunders

Yanni

Dorrington

et al. 2019

British Journal of Surgery

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Background: Postoperative complications after resection of oesophagogastric carcinoma can result in considerable early morbidity and mortality. However, the long-term effects on survival are less clear. Methods: All patients undergoing intentionally curative resection for oesophageal or gastric cancer between 2006 and 2016 were selected from an institutional database. Patients were categorized by complication severity according to the Clavien-Dindo classification (grades 0-V). Complications were defined according to an international consensus statement. The effect of leak and severe non-leak-related complications on overall survival, recurrence and disease-free survival was assessed using Kaplan-Meier analyses to evaluate differences between groups. All factors significantly associated with survival in univariable analysis were entered into a Cox multivariable regression model with stepwise elimination. Results: Some 1100 patients were included, with a median age of 69 (range 28-92) years; 48⋅1 per cent had stage III disease and cancer recurred in 428 patients (38⋅9 per cent). Complications of grade III or higher occurred in 244 patients (22⋅2 per cent). The most common complications were pulmonary (29⋅9 per cent), with a 13⋅0 per cent incidence of pneumonia. Rates of atrial dysrhythmia and anastomotic leak were 10⋅0 and 9⋅6 per cent respectively. Patients with a grade III-IV leak did not have significantly reduced overall survival compared with those who had grade 0-I complications. However, patients with grade III-IV non-leak-related complications had reduced median overall survival (19⋅7 versus 42⋅7 months; P < 0⋅001) and disease-free survival (18⋅4 versus 36⋅4 months; P < 0⋅001). Cox regression analysis identified age, tumour stage, resection margin and grade III-IV non-leak-related complications as independent predictors of poor overall and disease-free survival. Conclusion: Beyond the acute postoperative period, anastomotic leak does not adversely affect survival, however, other severe postoperative complications do reduce long-term overall and disease-free survival. Statistical analysisContinuous variables are described as median (i.q.r. or range) or mean(s.d.), and were compared using the Mann-Whitney U test and Student's t test respectively. The χ 2 test was used for analysis of discrete data. OS was

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The clinical significance of systemic inflammation score in esophageal squamous cell carcinoma

Cited by 32 publications

References 32 publications

Clinical application value of the prognostic nutritional index for predicting survival in patients with oesophageal squamous cell carcinoma undergoing chemoradiotherapy or radiotherapy

Clinical application value of the prognostic nutritional index for predicting survival in patients with oesophageal squamous cell carcinoma undergoing chemoradiotherapy or radiotherapy

Meta-analysis of risk factors and complications associated with atrial fibrillation after oesophagectomy

Impact of postoperative complications on disease recurrence and long-term survival following oesophagogastric cancer resection

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