2015
DOI: 10.1007/s13277-015-4152-1
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The clinical significance of systemic inflammation score in esophageal squamous cell carcinoma

Abstract: The objective of this study was to investigate the clinical significance of systemic inflammation score (SIS) and prognostic nutritional index (PNI) in esophageal squamous cell carcinoma (ESCC) patients who underwent esophagectomy. Records from 206 patients with histologically diagnosed ESCC who underwent esophagectomy at Qilu Hospital of Shandong University from January 2007 to December 2008 were retrospectively reviewed. The median disease-free survival (DFS) of this cohort was 32.3 months and 5-year DFS was… Show more

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Cited by 33 publications
(27 citation statements)
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“…However, there is some controversy regarding the PNI in oesophageal cancer research. Han et al [22] retrospectively analysed 206 patients with ESCC after esophagectomy and found that a high PNI had a positive effect on OS in patients with ECSS, but the PNI was not found to be an independent prognostic factor, which was not consistent with our finding that the PNI was significantly associated with the OS (P = 0.002) and therefore the prognosis of oesophageal cancer. Our multivariate analysis also showed that multiple variables were significantly associated with OS in oesophageal cancer, which was similar to the findings of Sun et al [23].…”
Section: Discussioncontrasting
confidence: 87%
“…However, there is some controversy regarding the PNI in oesophageal cancer research. Han et al [22] retrospectively analysed 206 patients with ESCC after esophagectomy and found that a high PNI had a positive effect on OS in patients with ECSS, but the PNI was not found to be an independent prognostic factor, which was not consistent with our finding that the PNI was significantly associated with the OS (P = 0.002) and therefore the prognosis of oesophageal cancer. Our multivariate analysis also showed that multiple variables were significantly associated with OS in oesophageal cancer, which was similar to the findings of Sun et al [23].…”
Section: Discussioncontrasting
confidence: 87%
“…First, the immunosuppressive effects of a prolonged severe illness may allow micrometastatic disease to flourish into a clinically relevant recurrence more rapidly than it would otherwise. Infectious complications after oesophagogastric surgery have been reported to produce a proinflammatory cytokine (interleukins 6 and 8)‐mediated response, which may also promote tumour progression after oesophagectomy. Second, the prolonged period needed to recover from this severe illness frequently precludes adjuvant chemotherapy, which has been shown to confer a significant survival benefit in responders to neoadjuvant chemotherapy.…”
Section: Discussionmentioning
confidence: 99%
“…Freeing the oesophagus from the pericardium increases the risk of left atrium‐related complications. Oesophagectomy is also associated with a high risk of morbidity that elicits a potent inflammatory response. Inflammatory mediators released in the circulation after surgery increase the chance of AF through alterations in the expression of sodium and calcium channels in atria.…”
Section: Discussionmentioning
confidence: 99%