The clinical significance of sentinel lymph node micrometastasis in breast cancer

Patani, Neill; Mokbel, Kefah

doi:10.1007/s10549-008-0021-6

Cited by 33 publications

(19 citation statements)

References 80 publications

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“…In breast cancer many reports showed poorer prognosis in patients with micrometastasis in SN [17,18]. Recently we reported on a retrospective multicenter study which showed a similar trend in patients with early-stage cervical cancer [2].…”

Section: Discussionmentioning

confidence: 60%

Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis

Cibula

Abu‐Rustum

Dušek

et al. 2012

Gynecologic Oncology

116

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Section: Discussionmentioning

confidence: 60%

Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis

Cibula

Abu‐Rustum

Dušek

et al. 2012

Gynecologic Oncology

116

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“…ITC have been found in 13% of patients in this study ranging between 10% and 18% in literature 13, 32, 33, but there remain some controversial issues addressing the management of ITC and micrometastases in limited tumor disease after positive SLN 34. A learning curve of this technique includes approximately 20 cases for navigation and SLNB.…”

Section: Discussionmentioning

confidence: 74%

High rate of solitary sentinel node metastases identification by fluorescence‐guided lymphatic imaging in breast cancer

Hirche

Mohr

Kneif

et al. 2011

Journal of Surgical Oncology

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“…None of the other three patients with ITC or negative SLN developed axillary lymph node spread after a mean follow-up of 4.7 years. Other authors identified ITC in approximately 10-15% of the patients [31,32], but the prognostic significance and optimal management according to stage migration due to ITC remains unclear [33]. Langer et al [34] revealed 96% of patients with ITC from SLN biopsy undergoing delayed ALND to have specimens free of macro-metastases and without benefit of ALND.…”

Section: Discussionmentioning

confidence: 99%

ICG fluorescence-guided sentinel node biopsy for axillary nodal staging in breast cancer

Hirche

Murawa

Mohr

et al. 2010

Breast Cancer Res Treat

205

145

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Background: Sentinel lymph node (SLN) biopsy is a selective approach to axillary staging of breast cancer with reduced morbidity. Current detection methods including radioisotope and blue dye show good results but some drawbacks are remaining. Indocyanine green (ICG) fluorescence detection was evaluated as a new method for SLN biopsy in breast cancer allowing both transcutaneous visualization of lymphatic vessels and intraoperative identification of SLN. Methods: Forty-three women with clinically node negative breast cancer received subareolar injection of ICG for fluorescence detection of SLN. All patients underwent either planned axillary lymph node dissection (ALND) with SLN biopsy or selective SLN biopsy to determine need for ALND. Clinical feasibility, detection rate, sensitivity, and axillary recurrence after isolated SLN biopsy were analyzed. Results: Overall ICG fluorescence imaging identified 2.0 SLN in average in 42 of 43 patients (detection rate: 97.7%). Metastatic involvement of the SLN was found in 17 of 18 nodal positive patients by conventional histopathology (sensitivity: 94.4%). Immunohistochemistry revealed isolated tumor cells in five further cases. There was only one false-negative case in 43 patients (5.6%). In 17 of 23 overall nodal positive patients, the SLN was the only positive lymph node. After a median follow-up of 4.7 years none of the patients presented with axillary recurrence. Conclusion: ICG fluorescence imaging is a new method for SLN biopsy in breast cancer with acceptable sensitivity and specificity comparable to conventional methods. One advantage of this technique is that it allows transcutaneous visualization of lymphatic vessels and intraoperative lymph node detection without radioisotope.Keywords Sentinel lymph node biopsy Á Breast cancer Á Indocyanine green (ICG) Á Fluorescence imaging Á Surgery Abbreviations ALND Axillary lymph node dissection ICG Indocyanine green SLN Sentinel lymph node

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The clinical significance of sentinel lymph node micrometastasis in breast cancer

Cited by 33 publications

References 80 publications

Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis

Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis

High rate of solitary sentinel node metastases identification by fluorescence‐guided lymphatic imaging in breast cancer

ICG fluorescence-guided sentinel node biopsy for axillary nodal staging in breast cancer

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