High rate of solitary sentinel node metastases identification by fluorescence‐guided lymphatic imaging in breast cancer

Hirche, Christoph; Mohr, Z.; Kneif, Sören; Murawa, Dawid

doi:10.1002/jso.22075

Cited by 33 publications

(22 citation statements)

References 36 publications

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“…per groin, range [4][5][6][7][8][9][10][11][12][13][14], of which 109 were SLNs (mean 2.2 nodes (SD 1.4) per groin, range 1-7).…”

Section: Resultsmentioning

confidence: 99%

“…[8] This figure drops to 5 per cent in China and is minimal in the rest of the world. [9] This has led to interest in the development of novel techniques not reliant upon radioisotopes (our Lancet reference in press -will be published by the time this is accepted) which are currently restricted uptake of dye by higher echelon nodes [10][11][12] and high false negative rates. [13] (This seems a nonsequitur -what does it mean?)…”

Section: Introductionmentioning

confidence: 99%

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160. Optimising magnetic sentinel lymph node biopsy in an in vivo porcine model

Ahmed

Anninga

Pouw

et al. 2014

European Journal of Surgical Oncology (EJSO)

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The magnetic technique for sentinel lymph node biopsy (SLNB) has been evaluated in several clinical trials, albeit under proscribed conditions. An in vivo porcine model was therefore developed to optimise the magnetic technique by evaluating the effect of differing volume of magnetic tracer and time of injection. A total of 48 sentinel node procedures were undertaken and 423 nodes (109 sentinel nodes) retrieved. There was a significant correlation between magnetometer counts and the tracer content of excised sentinel lymph nodes (SLNs) (r=0.82; p<0.001). Total numbers of tracer-containing SLNs increased with increasing volumes of tracer (p<0.001). Transcutaneous magnetometer counts increased with increasing time from injection of tracer (p<0.0001) and reached a plateau within 60 minutes. A non-statistically significant trend was observed between volume of tracer injected and tracer content of SLNs (p=0.07). We infer that increasing tracer volume and injecting prior to surgery improves transcutaneous 'hotspot' identification, but that very high injection volumes lead to an increase in the number of nodes excised.3

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“…per groin, range [4][5][6][7][8][9][10][11][12][13][14], of which 109 were SLNs (mean 2.2 nodes (SD 1.4) per groin, range 1-7).…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

160. Optimising magnetic sentinel lymph node biopsy in an in vivo porcine model

Ahmed

Anninga

Pouw

et al. 2014

European Journal of Surgical Oncology (EJSO)

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“…As shown in Table 1, since 2010, ICG was applied to SLN detection in breast cancer patients in over 40 studies and the detection rates were almost over 95 % [22,[25][26][27][28][29][30]. Some investigators compared the detection rates between ICG, blue dye, and nuclein and noticed the better performance of ICG compared with the blue dye and nuclein.…”

Section: The Developing Stagementioning

confidence: 99%

“…Some investigators analyzed the false-negative rate of ICG in SLNB and found it to be lower than 10 % [22,24,[26][27][28][30][31][32][33]. A meta-analysis of six studies, which used ICG as a tracer in SLNB of breast cancer patients, reported the sensitivity of about 92 % (85 %-96 %) and the specificity of about 100 % (97 %-100 %) [34].…”

Section: The Developing Stagementioning

confidence: 99%

Detection of Sentinel Lymph Nodes with Near-Infrared Imaging in Malignancies

Zeng

Bai

et al. 2018

Mol Imaging Biol

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Optical molecular imaging, a highly sensitive and noninvasive technique which is simple to operate, inexpensive, and has the real-time capability, is increasingly being used in the diagnosis and treatment of carcinomas. The near-infrared fluorescence dye indocyanine green (ICG) is widely used in optical imaging for the dynamic detection of sentinel lymph nodes (SLNs) in real time improving the detection rate and accuracy. ICG has the advantages of low scattering in tissue absorbance, low auto-fluorescence, and high signal-to-background ratio. The detection rate of axillary sentinel lymph nodes biopsy (SLNB) in breast cancers with ICG was more than 95 %, the false-negative rate was lower than 10 %, and the average detected number ranged from 1.75 to 3.8. The combined use of ICG with nuclein or blue dye resulted in a lower falsenegative rate. ICG is also being used for the sentinel node detection in other malignant cancers such as head and neck, gastrointestinal, and gynecological carcinomas. In this article, we provide an overview of numerous studies that used the near-infrared fluorescence imaging to detect the sentinel lymph nodes in breast carcinoma and other malignant cancers. It is expected that with improvements in the optical imaging systems together with the use of a combination of multiple dyes and verification in large clinical trials, optical molecular imaging will become an essential tool for SLN detection and image-guided precise resection.

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“…Recently, ICGI has been used to detect SLNs in breast cancer patients. According to the first studies, ICGI is able to find the same lymph nodes as conventional radiotracer [40][41][42][43][44][45][46][47][48][49][50][51]. Also, ICG has been combined with 99m Tc as a hybrid radiotracer, where it can be used to ease the detection of SLN, and to replace blue dye [52].…”

Section: Sentinel Lymph Node Biopsymentioning

confidence: 99%