The clinical significance of CDK1 expression in oral squamous cell carcinoma

Abstract

Objectives: To evaluate the clinical significance of cyclin-dependent kinase 1 (CDK1) in 77 oral squamous cell carcinomas (OSCC) using immunohistochemical methods. Study Design: Immunohistochemical expression of CDK1 was compared with various clinicopathological features in 77 OSCC and 60 controlled epithelia adjacent to the tumours. In addition, correlation of CDK1 expression and prognostic and the 5-year accumulative survival rate of OSCC were investigated. Results: The CDK1 protein was expressed in 52 cases of 77 tumor tissues (67.5%), compared with 21 cases of 60 controlled (35.0%). The expression of CDK1 was significantly correlated with the histological grade of OSCC (P<0.05). The CDK1 protein was over-expressed in recurrent tumors or in those with lymph node metastasis. Statistical analysis showed a significant reduction in the 5-year accumulative survival rate in CDK1 positive cases compared with CDK1 negative cases (P<0.05). Namely, the CDK1 positive patients had poor prognosis. Conclusions: The expression of CDK1 might serve as malignant degree and prognostic markers for the survival of OSCC. Key words:Cyclin-dependent kinase 1 (CDK1), oral squamous cell carcinoma (OSCC), immunohistochemistry, cell proliferation.

The expression of CDK1 is associated with proliferation and can be a prognostic factor in epithelial ovarian cancer

“…Moreover, in several human cancers, the role of CDK1 has been well characterized. Some researchers observed that in breast, hepatocarcinoma, oral, and lung carcinomas, CDK1 was found to be upregulated and correlated with clinicopathological factors [9,[17][18][19]. Besides, CDK1 is required for the distant metastases of colon cancer [11].…”

Diagnostic value of cyclin-dependent kinase/cyclin-dependent kinase inhibitor expression ratios as biomarkers of locoregional and hematogenous dissemination risks in oral squamous cell carcinoma

“…Upregulation of CDK1 is observed in OSCC and its overexpression is associated with malignant behavior. CDK1 is therefore expected to be an indicator of poor prognosis (6,12). CDK2 plays various roles in DNA synthesis, modulation of G 2 progression and in G 1 /S transition (13).…”

“…Our previous studies conducted comprehensive integrin gene expression analysis to identify prognostic biomarkers that predict the clinical behavior of OSCC and identified that the two gene expression ratios, ITGA3/CD9 and ITGB4/JUP, reflect malignant behavior associated with lymph node metastasis (LNM) and distant metastasis, respectively (3)(4)(5). In the present study, the diagnostic value of cyclins, cyclin-dependent kinases (CDKs) and CDK inhibitors (CDKIs) gene expression was investigated since these molecules play central roles in cell cycle control, have been extensively studied, mediate carcinogenesis and can be used as prognostic factors of cancer (6,7). These genes became of particular interest recently as possible molecular targets of cancer therapy (8).…”

The role of cyclin‐dependent kinases in oral potentially malignant disorders and oral squamous cell carcinoma

“…The role of CDKs in oral carcinogenesis has attracted researcher interest for many years. Several studies reveal an alteration of the expression of CDKs in oral squamous cell carcinoma (OSCC) . In this regard, Ansari et al analysed the TCGA database in order to identify the level of dysregulation of cell cycle genes among 24 different human cancers and the impact of these genes on patient survival.…”

“…Likewise, Chen et al showed that CDK1 expression was significantly correlated with recurrent tumours and lymph node metastasis. Therefore, CDK1 was considered a poor prognostic indicator among patients with OSCC . Furthermore, Poomsawat et al documented that CDK4 and CDK6 were overexpressed in OSCC compared to normal tissue .…”