The clinical significance of carotid intima-media thickness in cardiovascular diseases: a survey in Beijing

Liu, L; Zhao, Feng; Yang, Ying; Qi, Litong; Zhang, B W; Chen, F; Ciren, D; Zheng, Bo; Wang, Suxin; Huo, Yong; Liu, L S

doi:10.1038/sj.jhh.1002301

Cited by 21 publications

(12 citation statements)

References 20 publications

(35 reference statements)

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“…Our results suggest that individuals who exhibit an elevated central SBP response to stress may be at greater risk for carotid TOD. Regardless of whether carotid IMT represents atherosclerosis, IMT measurement may still reflect total burden of atherosclerosis at other sites in the arterial system (17) and remains a marker for cardiovascular risk (4, 5). …”

Section: Discussionmentioning

confidence: 99%

“…Carotid intima-media thickness (IMT) is an established measure of subclinical atherosclerosis and TOD (4, 5). Although there is an association between brachial BP and carotid IMT (6), mounting evidence suggests that central BP is more tightly coupled pathophysiologically to regional TOD (6, 7), and as such may be a stronger predictor of CV outcomes than brachial BP (8, 9).…”

Section: Introductionmentioning

confidence: 99%

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The relationship between carotid blood pressure reactivity to mental stress and carotid intima-media thickness

Augustine¹,

Lefferts²,

Gump³

et al. 2014

Atherosclerosis

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Background Brachial blood pressure (BP) reactivity to stress predicts large artery damage and future cardiovascular (CV) events. Central BP is an emerging risk factor associated with target organ damage (TOD). Currently, little is known about the central BP response to mental stress and its association to TOD. Methods and Results Twenty-five healthy, non-obese adults completed a computerized mental stress test. Brachial and carotid systolic (S)BP reactivity to stress were calculated as SBP during stress minus resting SBP. Resting carotid intima-media thickness (IMT) was also measured. Carotid SBP reactivity to stress was significantly associated with carotid IMT, independent of age, sex, body mass index, non-high density lipoprotein cholesterol and brachial SBP reactivity to stress (r=0.386, p<0.05). Conclusion The relationship between carotid SBP reactivity and carotid IMT suggests that the central BP response to stress may prove to be an early risk marker for potential subclinical TOD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The relationship between carotid blood pressure reactivity to mental stress and carotid intima-media thickness

Augustine¹,

Lefferts²,

Gump³

et al. 2014

Atherosclerosis

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“…Data were obtained by an experienced sonographer in the central laboratory of echocardiography of Peking University First Hospital. The examination and measurement method were performed as previously described . Three measurements were obtained for each site at 5‐mm intervals at the end of cardiac diastole.…”

Section: Methodsmentioning

confidence: 99%

Correlating the relationship between interarm systolic blood pressure and cardiovascular disease risk factors

Zhang

Yang

et al. 2017

J of Clinical Hypertension

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Interarm systolic blood pressure difference (IASBPD) can predict cardiovascular disease. To investigate the relationship between IASBPD and cardiovascular disease risk factors, a total of 1426 individuals were studied. Blood pressure was assessed simultaneously and IASBPD was expressed as the absolute difference value (|R−L|).Cardiovascular disease risk factors were compared between the high IASBPD group (IASBPD ≥10 mm Hg) and the normal IASBPD group (IASBPD <10 mm Hg). An increased prevalence of hypertension, body mass index, and systolic and diastolic blood pressure were observed in the high IASBPD group (P<.05), associated with the enhanced mean values of intima-media thickness and maximum intima-media thickness (P<.05). Brachial-ankle pulse wave velocity was increased, while ankle-brachial index was lower in the high IASBPD group (P<.05). Multivariate logistic regression analysis revealed that IASBPD ≥10 mm Hg was positively associated with body mass index (odds ratio, 1.077; P=.002) and systolic blood pressure (odds ratio, 1.032; P<.001), and negatively associated with ankle-brachial index (odds ratio, 0.038; P<.001). | INTRODUCTIONThe lower ankle-brachial index (ABI) is associated with the incidence of cardiovascular disease (CVD) and peripheral artery disease (PAD).The question is raised "what does the systolic blood pressure (SBP) difference between the two arms indicate?" It has been reported that interarm SBP difference (IASBPD) is associated with peripheral vascular disease, which has been considered a predictor of CVD.1 A previous study demonstrated that CVD can be predicted when IASBPD is ≥10 mm Hg. 2 However, the association between IASBPD and cardiovascular morbidity and mortality remains elusive.Current hypertension guidelines suggest that blood pressure (BP) assessment in both arms should be used as an initial evaluation parameter of hypertension. An interarm BP difference of <10 mm Hg can be considered a normal condition, whereas the difference of ≥20/10 mm Hg demands further attention and investigation. 3 The BP difference between arms was first reported more than 100 years ago, but its clinical significance was not recognized until recently. A meta-analysis showed that the prevalence of IASBPD ≥10 mm Hg was 19.6%, 4 indicating that this is not a small probability event and PAD is also not the unique reason for IASBPD. Knowledge of the interarm BP difference remains limited, which could be important for accurate BP measurement and treatment decisions, and may be a potential risk marker for CVD. Although a questionnaire survey revealed that a consensus has been reached among 77% of physicians that BP should be measured in both arms, only 30% of respondents agreed with this recommendation, while over half disagreed, and a mere 13% adhered to it. 5 These studies show that most of the clinicians ignored the importance of measurement of BP in both arms because they did not realize the clinical significance.Carotid intima-media thickness (IMT) and plaque formation are associated with CVD, 6 as we...

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“…Participants with a fasting glucose ≥ 7.0 mmol/L and a 2-h glucose ≥ 11.1 mmol/L on the oral glucose tolerance test were also de ned as diabetic. Stroke, including intracerebral hemorrhage, cerebral infarction, and transient ischemic attack, was determined based on a history of data collected from hospitalizations and outpatient records, which were con rmed by computed tomography (CT) or magnetic resonance imaging (MRI) scan [11]. A history of old myocardial infarction, percutaneous coronary intervention, and coronary artery bypass grafting were all included in CHD.…”

Section: De Nition Of Cardiovascular Risk Factors and Diseasementioning

confidence: 99%

Association of Epicardial Fat Thickness With Left Ventricular Diastolic Function Parameters in a Community Population

Zhang

Yang

et al. 2021

Preprint

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Purpose We examined the relationship between EFT measured by echocardiography and LV diastolic function parameters in a Beijing community population.Methods We included 1004 participants in this study. Echocardiographic parameters including E and A peak velocity, the early diastolic velocities (e’) of the septal and lateral of mitral annulus using tissue doppler imaging, E/e’, and EFT, were measured. EFT1 was measured perpendicularly on the right ventricular free wall at end-diastole in the extension line of the aortic root. EFT2 was the maximum thickness measured perpendicularly on the right ventricular free wall at end-diastole. Multivariate linear regression was used to analyze the relationship between EFT and the mean e’ and E/e’.Results The mean age of the participants was 63.91 ± 9.02 years old (51.4% men). EFT1 and EFT2 were negatively correlated with e’ lat, e’ sep, and e’ mean (p < 0.05), and positively correlated with E/e’ lat, E/e’ sep, and E/e’ mean. Multivariate regression analysis showed that EFT1 and EFT2 were independently and negatively correlated with e’ mean (EFT1: β = −0.089 [95% confidence interval = −0.177, −0.000, p = 0.050]; EFT2: β = −0.078 [95% confidence interval = −0.143, −0.012, p = 0.020]). There were no interactions between EFT and any covariates, including age or heart groups, sex, BMI, or presence of hypertension, diabetes, or coronary heart disease in relation to LV diastolic dysfunction.Conclusions EFT was negatively and independently correlated with e’ mean, suggesting that more attention to this type of adipose fat is required for cardiovascular disease therapy.

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The clinical significance of carotid intima-media thickness in cardiovascular diseases: a survey in Beijing

Cited by 21 publications

References 20 publications

The relationship between carotid blood pressure reactivity to mental stress and carotid intima-media thickness

The relationship between carotid blood pressure reactivity to mental stress and carotid intima-media thickness

Correlating the relationship between interarm systolic blood pressure and cardiovascular disease risk factors

Association of Epicardial Fat Thickness With Left Ventricular Diastolic Function Parameters in a Community Population

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