The Clinical Significance of Both IgM and IgG Anticardiolipin Antibodies in Non-Hodgkin’s Lymphoma

Saber, Manal Mohamed

doi:10.4172/2155-9899.1000436

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…7 In another study by Saber, the presence of IgM aCL antibody had a significant negative correlation with treatment response and positive correlation with NHL relapse. 33 Multiple hypotheses have been proposed for the genesis of APAs in NHL. Some authors believe that the APAs are produced directly by the clonal lymphoma cells, while others state that the host immune system tends to produce autoantibodies against tumor-associated antigens.…”

Section: Discussionmentioning

confidence: 99%

Antiphospholipid Antibodies Are Not Associated with Clinical Parameters or Prognostic Outcomes in Patients with Non-Hodgkin's Lymphoma

et al. 2020

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Background Antiphospholipid antibodies (APAs) are found quite frequently in patients with non-Hodgkin’s lymphoma (NHL). However, the clinical significance of these antibodies is largely unknown. This study aims to delineate the clinical and prognostic role of APAs in NHL patients. Patients and Methods Consecutive patients of NHL were screened for lupus anticoagulant (LA), IgG/IgM anticardiolipin antibody, and IgG/IgM anti-β2-glycoprotein I at the time of diagnosis. Baseline investigations, staging, and treatment were done as per institutional protocol. Patients were followed up until the last known outpatient visit or death. All were screened at each visit for any thromboembolic event. The association of APA status with baseline NHL characteristics and treatment response was evaluated by univariate analysis. Kaplan–Meier survival analysis was used to compare the final outcome in patients with or without APAs. Patients who were initially APA positive were retested for the corresponding antibody at the end of chemotherapy. Results Twenty-four out of 105 patients (22.8%) were APA positive at diagnosis. The presence of APA was not significantly associated with NHL stage, histology, International Prognostic Index score, activated partial thromboplastin time, or treatment response. The median duration of follow-up was 15 months. Only four patients developed venous thrombosis; none was APA positive. There was no statistically significant difference in overall survival between the two groups (p = 0.471). Patients, who were APA positive initially, tested negative at the end of treatment, irrespective of treatment response. Conclusion APAs are encountered more frequently in NHL patients than in the general population. However, APAs do not correlate with disease severity, thrombosis risk, treatment outcome, or overall survival.

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Section: Discussionmentioning

confidence: 99%

Antiphospholipid Antibodies Are Not Associated with Clinical Parameters or Prognostic Outcomes in Patients with Non-Hodgkin's Lymphoma

et al. 2020

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“…Marine macroalgae (seaweeds) are a diverse group of organisms that play a vital role in the productivity, structure, and function of coastal ecosystems (Dawes and Mathiesen, 2008). They are considered as a good source of vitamins, fibers, proteins, polyunsaturated fatty acids and other important secondary metabolites that are used in traditional medicine applications (Cho et al, 2011 andAli et al, 2017).These metabolites are of potential pharmaceutical value with antibacterial, antiviral, antifungal, anticancer, anticonvulsant and antioxidant activities (Yuan et al, 2005;Zubia et al, 2007;Baleta et al, 2017;Rajkumar et al 2018;Yende et al, 2018;Maddah et al, 2019;Madkour et al, 2019;Saber, 2019 andSujatha et al, 2019). They are used as bio-fertilizers (Hashem et al, 2019), as biofuel, human food, animal fodder and used for hydrocolloid production (Bruton et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Impact of Different Geographical Locations on Genetic Variation and Phytochemical Constituents of Two Medicinal Marine Algae.

Saleh

El-Atroush

2020

Taeckholmia

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Genetic variations and phytochemical constituents of Dictyota dichotoma and Sargassum dentifolium, collected from Hurghada and Abu-Qir bay, were investigated. Results revealed an increase in the concentrations of carotenoids, sugars and DPPH% in the samples of both algal species collected from Hurghada as compared with those collected from Abu-Qir. Regarding the samples collected from Hurghada, an increase in the concentrations of chlorophyll a, b and phenols was recorded in S. dentifolium; while a decrease in chlorophyll a, b only was observed in D. dichotoma. No significant difference was observed in phenol concentrations between D. dichotoma samples collected from the two studied localities. DNA was isolated and thirteen SCoT molecular markers were used to detect the genetic variations between the samples of the two localities. In D. dichotoma, the total average of polymorphism is 56.68%. SCoT-1 exhibited the highest polymorphism (80%), while SCoT-28 recorded the lowest polymorphism (35.71%). In S. dentifolium, the total average of polymorphism is 61.63%. SCoT-3 showed the highest polymorphism (90%), while SCoT-13 exhibited the lowest polymorphism (0.09%). In addition, BSI factor showed a marked difference between the two studied algae that it was 0.87 % in D. dichotoma and 0.77 % in S. dentifolium. Variation in geographical location affects genetic variation and phytochemical composition of D. dichotoma and S. dentifolium. The difference in the responses of the two studied algae to the change of locality and environmental conditions may reflect differences in their gene expression. Moreover, the efficiency of SCoT markers to discriminate between algal species collected from different localities has been confirmed.

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The Clinical Significance of Both IgM and IgG Anticardiolipin Antibodies in Non-Hodgkin’s Lymphoma

Abstract: Background: Anticardiolipin (ACL) antibodies are associated with a wide variety of disorders including malignancies. The aim of this study was to investigate the prevalence and prognostic implication of ACL antibodies in patients with Non-Hodgkin's lymphoma (NHL).

Cited by 2 publications

References 37 publications

Antiphospholipid Antibodies Are Not Associated with Clinical Parameters or Prognostic Outcomes in Patients with Non-Hodgkin's Lymphoma

Antiphospholipid Antibodies Are Not Associated with Clinical Parameters or Prognostic Outcomes in Patients with Non-Hodgkin's Lymphoma

Impact of Different Geographical Locations on Genetic Variation and Phytochemical Constituents of Two Medicinal Marine Algae.

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