The clinical response and systemic effects of non‐surgical periodontal therapy in end‐stage renal disease patients: a 6‐month randomized controlled clinical trial

Fang, Fuchun; Wu, Buling; Qu, Qian; Gao, Jie; Yan, Wenjuan; Huang, Xiaohong; Ma, Dandan; Jin, Yue; Chen, Ting; Liu, Fei; Liu, Ying

doi:10.1111/jcpe.12411

Cited by 56 publications

(84 citation statements)

References 34 publications

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“…The results are in agreement with some studies, which compared only the oral condition of patients in end stage renal disease to that of controls [24, 28, 31, 32]. However, the results of this study differed from those of Bayraktar et al [26] which found higher GI in patients with chronic renal failure.…”

Section: Discussionsupporting

confidence: 89%

“…Although there are several studies in the literature that compare periodontal disease with renal failure, most studies have compared patients on dialysis (hemodialysis and peritoneal dialysis) to a control group [24–26, 28, 31–33] and in some cases include a predialysis group [27, 29, 34, 35]. Only the study by Garcez et al [36] assesses the oral health status in a group with the IRC in its initial stage (stage 2 CRD) by comparing it to a control group.…”

Section: Discussionmentioning

confidence: 99%

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Medical and Periodontal Clinical Parameters in Patients at Different Levels of Chronic Renal Failure

Perozini

Ruivo

Ricardo

et al. 2017

International Journal of Dentistry

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Aim. To assess the clinical periodontal and medical parameters in patients with chronic renal failure (CRF) at different levels of renal disease. Background. CRF is a progressive and irreversible loss of renal function associated with a decline in the glomerular filtration rate. Periodontal disease is a destructive inflammatory disease affecting periodontal tissues that shows high prevalence in patients with CRF. Materials and Methods. 102 CRF patients were included and divided into an early stage group (EG), predialysis group (PDG), and hemodialysis group (HDG). The medical parameters were taken from the patients' records. Results. Periodontal clinical condition differed among the CRF groups. Clinical attachment loss was greater in the HDG and PDG group compared to the EG (p = 0.0364); the same was observed in the Plaque Index (p = 0.0296); the others periodontal parameters did not show any differences. Ferritin levels were significantly higher in the HDG when compared to the EG and PGD (p < 0.0001), and fibrinogen was higher in PDG compared with the others (p < 0.0001); the triglycerides also showed higher values in the HDG compared with the other groups (p < 0.0001). Conclusion. The patients with renal involvement should have a multidisciplinary approach to an improvement in their oral and systemic health.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Medical and Periodontal Clinical Parameters in Patients at Different Levels of Chronic Renal Failure

Perozini

Ruivo

Ricardo

et al. 2017

International Journal of Dentistry

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“…Fang et al. (Fang et al., ), Guo & Lin (Guo & Lin, ), and Vilela et al. (Vilela et al., ) reported improvements for both parameters whereas Graziani et al.…”

Section: Resultsmentioning

confidence: 98%

“…Inflammatory markers have also been analyzed in patients with CKD such as IL‐6 (Fang et al., ; Guo & Lin, ; Vilela et al., ) or CRP (Fang et al., ; Graziani et al., ; Guo & Lin, ; Vilela et al., ) after periodontal therapy. Fang et al.…”

Section: Resultsmentioning

confidence: 99%

Association between periodontitis and chronic kidney disease: Systematic review and meta‐analysis

et al. 2018

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A systematic review and meta-analysis were conducted to evaluate the association between periodontitis (PD) and chronic kidney disease (CKD) and to explore the potential influence of periodontal treatment in patients with CKD. Databases (PubMed, Web of Science, Science direct, Cochrane Database) were screened for relevant articles, focusing on the periodontal status of patients with CKD, published until December 2017. Five hundred and fifty-three articles were identified, and 37 fulfilled the inclusion criteria and were considered in this systematic review. Seventeen articles were included in the meta-analysis and 7 in the review focusing on the impact of periodontal treatment. Most of the identified studies indicated an increased incidence of PD in patients with CKD. Meta-analysis showed an association between CKD and PD, and strength of this association was increased when severe PD was considered (OR = 2.39 (1.70-3.36)). The association could be observed even after adjustment for major CKD risk factors or use of precise diagnosis criteria (OR = 2.26 for severe PD (1.69-3.01)). Analysis of cohort studies indicated an incident rate ratio (IRR) of 1.73. Periodontitis is associated with CKD after multivariable adjustment. Further studies are necessary to determine whether prevention or treatment of PD can reduce the incidence and/or severity of CKD.

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“…, Fang et al. ). However, the only investigations into associations between periodontitis and mortality rates (all‐cause and CVD) in patients with CKD have involved relatively small numbers of patients (ranging from 122–253 patients) on haemodialysis and with a short follow‐up period (ranging from 18 months to 6 years) (Kshirsagar et al.…”

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confidence: 99%

Association between periodontitis and mortality in stages 3–5 chronic kidney disease: NHANES III and linked mortality study

Sharma

Dietrich

Ferro

et al. 2016

J Clinic Periodontology

117

101

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IntroductionPeriodontitis may add to the systemic inflammatory burden in individuals with chronic kidney disease (CKD), thereby contributing to an increased mortality rate. This study aimed to determine the association between periodontitis and mortality rate (all‐cause and cardiovascular disease‐related) in individuals with stage 3–5 CKD, hitherto referred to as “CKD”.MethodsSurvival analysis was carried out using the Third National Health and Nutrition Examination Survey (NHANES III) and linked mortality data. Cox proportional hazards regression was employed to assess the association between periodontitis and mortality, in individuals with CKD. This association was compared with the association between mortality and traditional risk factors in CKD mortality (diabetes, hypertension and smoking).ResultsOf the 13,784 participants eligible for analysis in NHANES III, 861 (6%) had CKD. The median follow‐up for this cohort was 14.3 years. Adjusting for confounders, the 10‐year all‐cause mortality rate for individuals with CKD increased from 32% (95% CI: 29–35%) to 41% (36–47%) with the addition of periodontitis. For diabetes, the 10‐year all‐cause mortality rate increased to 43% (38–49%).ConclusionThere is a strong, association between periodontitis and increased mortality in individuals with CKD. Sources of chronic systemic inflammation (including periodontitis) may be important contributors to mortality in patients with CKD.

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The clinical response and systemic effects of non‐surgical periodontal therapy in end‐stage renal disease patients: a 6‐month randomized controlled clinical trial

Abstract: Non-surgical periodontal therapy can effectively improve periodontal, circulating inflammatory and nutritional status in ESRD patients. Non-surgical periodontal therapy, as a relatively simple intervention, has beneficial systemic effects in ESRD patients.

Cited by 56 publications

References 34 publications

Medical and Periodontal Clinical Parameters in Patients at Different Levels of Chronic Renal Failure

Medical and Periodontal Clinical Parameters in Patients at Different Levels of Chronic Renal Failure

Association between periodontitis and chronic kidney disease: Systematic review and meta‐analysis

Association between periodontitis and mortality in stages 3–5 chronic kidney disease: NHANES III and linked mortality study

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