The clinical pattern of diabetic nephropathy in Type II Diabetes Mellitus in North Central Nigeria

Prevalence of dyslipidemia among adult diabetic patients with overt diabetic nephropathy in Anambra state South-East Nigeria

“…[19] Studies from Nigeria have reported similar findings, where hypercholesterolemia was present in 43.5% and hypertriglyceridemia in 34.8% of patients with Type 2 DM. [2] The combination of hypercholesterolemia and hypertriglyceridemia found in DN patients in this study is similar to that reported in the Saudi Arabian study, [17,18] where significantly higher levels of TG and TC were noted among patients with DN. This also agrees with reports from the Diabetes Control and Complications Trial/ Diabetes Interventions and Complications Study (DCCT/ EDIC) [20,21] cohort group study, where the lipid profile relating to albumin excretion rate (AER) is elevated TG, TC, and LDL-C.…”

“…It is also a common cause of endstage renal disease (ESRD) worldwide and is prevalent in our environment. [1][2][3] With the increasing epidemic of diabetes mellitus and its far reaching complications worldwide, the implication in a developing country like Nigeria is that of identification of risk factors that accelerate the onset of chronic complications like DN and institution of measures to retard its progression to ESRD. Dyslipidemia using World Health Organization (WHO) criteria [serum triglyceride-150-400 mg/dL (1.7-4.5 mmol/L), total cholesterol (TC) > 200 mg/dL (>5.2 mmol/L), low-density disease after the initiating event has damaged the glomerular capillary wall, thereby allowing increased passage of lipids and lipoproteins into the renal mesangium.…”

Dyslipidemia in Nigeria: Prevalence and pattern

“…Dyslipidemia was highest in patients with diabetic nephropathy. • Agaba et al [28] from North Central Nigeria also reported high prevalence rate of dyslipidemia in type 2 diabetes mellitus subjects with the commonest patterns being high TC (43.5%) and TG (34.8%) levels.…”

Characteristics of end stage renal disease diabetic patients in two countries with different socioeconomic conditions

“…In Nigeria, increases in both the incidence of type 2 diabetes and in the percent of type 2 diabetic patients developing clinical manifestations of diabetic nephropathy (probably because of improving survival) have been reported [3,4]. In Nigerian patients with type 2 diabetes, the prevalence of diabetic nephropathy rose from 7% in 1963 to 57% in 1999 [4][5][6][7][8]. Once overt diabetic nephropathy occurs, there is relentless progression to ESRD [9].…”