Prevalence of dyslipidemia among adult diabetic patients with overt diabetic nephropathy in Anambra state South-East Nigeria

Jisieike-Onuigbo, Nonyelum Nnenna; Unuigbe, EI; Kalu, OA; Oguejiofor, CO; Onuigbo, PC

doi:10.4103/1119-3077.84009

Cited by 17 publications

(19 citation statements)

References 15 publications

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“…Our proposed explanation is consistent with results of clinical and in vitro studies which found that an enhanced level of IL-6 contributes to the endothelial cell dysfunction [35] and accelerates the development of chronic micro- and macrovascular complications [13, 36]. Moreover, some clinical results strongly suggest that enhanced IL-6 concentration is most associated with the development of diabetic kidney disease [37]. It seems this could be related to enhanced stimulation of mesangial cell proliferation and interferes with the extracellular dynamics of matrix formation at the podocyte level by IL-6 [38].…”

Section: Discussionsupporting

confidence: 89%

Association Between IL-6 Concentration and Diabetes-Related Variables in DM1 Patients with and without Microvascular Complications

et al. 2013

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Interleukin 6 (IL-6) plays an important role in the initiation and acceleration of chronic inflammation and could contribute to development of microvascular complications in patients with type 1 diabetes (DM1). Therefore, this study was aimed to investigate the association between concentration of IL-6 in relation to glucose control, lipid profile, and body mass index (BMI) in 69 DM1 patients subdivided according to the absence or presence of microvascular complications. BMI, level of fasting plasma glucose (FPG), and concentrations of total cholesterol (TCH), LDL cholesterol (LDL-C), and IL-6 were higher in DM1 patients compared to the control group. In DM1 patients, IL-6 concentration was positively correlated with level of FPG, LDL-C, TCH concentrations, and BMI. These correlations were stronger in the subgroup of patients with microvascular complications. In addition, BMI independently influences IL-6 concentration in DM1 patients. In conclusion, elevated IL-6 concentration is associated with diabetes-related variables which could accelerate progression of microvascular complications in DM1 patients.

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Section: Discussionsupporting

confidence: 89%

Association Between IL-6 Concentration and Diabetes-Related Variables in DM1 Patients with and without Microvascular Complications

et al. 2013

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“…A study among related South Indian population has also shown that TC, TG, HDL-C, and LDL-C were significantly different between diabetic and diabetic nephropathy patients [14]. A study conducted even in a different ethnic population has observed results similar to the present study [15]. Another study showed that dyslipidemia associated with diabetic nephropathy is not limited to T2DM subjects, but is present among type 1 patients as well [16].…”

Section: Discussionsupporting

confidence: 81%

Lipid Abnormalities in Type 2 Diabetes Mellitus Patients with Overt Nephropathy

Palazhy

Viswanathan

2017

Diabetes Metab J

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BackgroundDiabetic nephropathy is a major complication of diabetes and an established risk factor for cardiovascular events. Lipid abnormalities occur in patients with diabetic nephropathy, which further increase their risk for cardiovascular events. We compared the degree of dyslipidemia among type 2 diabetes mellitus (T2DM) subjects with and without nephropathy and analyzed the factors associated with nephropathy among them.MethodsIn this retrospective study, T2DM patients with overt nephropathy were enrolled in the study group (n=89) and without nephropathy were enrolled in the control group (n=92). Both groups were matched for age and duration of diabetes. Data on total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), urea and creatinine were collected from the case sheets. TG/HDL-C ratio, a surrogate marker for small, dense, LDL particles (sdLDL) and estimated glomerular filtration rate (eGFR) were calculated using equations. Multivariate analysis was done to determine the factors associated with eGFR.ResultsDyslipidemia was present among 56.52% of control subjects and 75.28% of nephropathy subjects (P=0.012). The percentage of subjects with atherogenic dyslipidemia (high TG+low HDL-C+sdLDL) was 14.13 among controls and 14.61 among nephropathy subjects. Though serum creatinine was not significantly different, mean eGFR value was significantly lower among nephropathy patients (P=0.002). Upon multivariate analysis, it was found that TC (P=0.007) and HDL-C (P=0.06) were associated with eGFR among our study subjects.ConclusionOur results show that dyslipidemia was highly prevalent among subjects with nephropathy. Regular screening for dyslipidemia may be beneficial in controlling the risk for adverse events among diabetic nephropathy patients.

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“…Besides lower hypertriglyceridemia prevalence, other lipid derangements were higher in these apparently healthy subjects of this study than the prevalence demonstrated recently in hospital patients like diabetics [8]. This is quite worrisome and deserves attention.…”

Section: Discussioncontrasting

confidence: 51%

Lipid patterns, alcohol intake and BMI of adult Nigerians in a sub-urban slum in Enugu, Nigeria

Ahaneku

Osuji

et al. 2014

Pan Afr Med J

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IntroductionDemonstration of cardiovascular disease (CVD) markers in healthy subjects with normal blood chemistry tests underscores the need to study social determinants of risk factors to aid primary prevention worldwide; particularly in slums which harbor nearly 80% of rural to urban migrants in the epidemiologically transiting Africa where CVDs were previously unknown. The objective of this study was to assess lipids in relationship to alcohol consumption and BMI in a Nigerian slum.MethodsCross sectional community based prevalent study involving 191 apparently healthy inhabitants aged 18- 85 years recruited by convenient sampling. Heights, weights and BMIs were measured/ calculated, venous blood samples collected and lipid analysis done procedurally. Excel 13 and SPSS statistical soft ware were used for analysis and chart representation.ResultsTheir mean parameters were: Age (43.87 ± 1.62 years), triglycerides (TG; 1.20 ± 0.08mmol/L), total Cholesterol (TC; 4.54 ± 1.70mmol/L), low density lipoprotein cholesterol (LDLC; 3.69 ± 1.69mmol/L), high density lipoprotein cholesterol (HDLC; 0.61 ± 0.24mmol/L), RPI (7.12 ± 5.24), body mass index (BMI; 25.08 ± 5.18Kg/M2). TG and HDLC values were lowest in obese non alcohol drinkers while all other lipid parameters increased with BMI in both drinkers and non drinkers. Low HDLC prevalence was lowest in obese alcohol drinkers and highest (100%) in their non drinking counterparts. Having favourable HDLC was highest in daily alcohol consumers. No weekly drinker (0%) had favourable HDLC.ConclusionIgnorance, poor nutritional and health education may be major factors in the strategic challenge posed by the emergence of non communicable diseases in Africans.

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Prevalence of dyslipidemia among adult diabetic patients with overt diabetic nephropathy in Anambra state South-East Nigeria

Abstract: Diabetic patients with overt diabetic nephropathy have significant dyslipidemia and aggressive lipid lowering in these patients may retard their progression to end-stage renal disease.

Cited by 17 publications

References 15 publications

Association Between IL-6 Concentration and Diabetes-Related Variables in DM1 Patients with and without Microvascular Complications

Association Between IL-6 Concentration and Diabetes-Related Variables in DM1 Patients with and without Microvascular Complications

Lipid Abnormalities in Type 2 Diabetes Mellitus Patients with Overt Nephropathy

Lipid patterns, alcohol intake and BMI of adult Nigerians in a sub-urban slum in Enugu, Nigeria

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