The clinical neurophysiology of COVID-19-direct infection, long-term sequelae and para-immunization responses: A literature review

Haykal, M. Ayman; Menkes, Daniel L.

doi:10.1016/j.cnp.2022.09.005

Cited by 9 publications

(4 citation statements)

References 103 publications

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“…Electroencephalography (EEG) studies have also provided insights into the neurophysiological impact of SARS-CoV-2 infection, revealing changes in brain electrical activity that correlate with cognitive deficits in PCS patients [ 17 , 20 , 21 , 22 , 23 , 24 , 25 ]. Investigating the neural substrates of cognitive deficits and fatigue in PCS patients can provide valuable insights into the pathophysiology of this condition and open the way to the development of targeted interventions for affected individuals.…”

Section: Introductionmentioning

confidence: 99%

Lowered Delta Activity in Post-COVID-19 Patients with Fatigue and Cognitive Impairment

Quercia

Cerasa

Dezi³

et al. 2023

Biomedicines

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In post-COVID-19 syndrome (PCS), neurocognitive symptoms and fatigue are often associated with alterations in electroencephalographic (EEG) activity. The present study investigates the brain source activity at rest in PCS patients (PCS-pts) perceiving cognitive deficits and fatigue. A total of 18 PCS-pts and 18 healthy controls (HCs) were enrolled. A Montreal Cognitive Assessment (MoCA), Perceived Cognitive Difficulties Scale (PDCS) and Fatigue Severity Scale (FSS) were administered for assessing the symptoms’ severity. Brain activity at rest, both with open (OE) and closed eyes (CE), was recorded by high-density EEG (Hd-EEG) and localized by source estimation. Compared to HCs, PCS-pts exhibited worse performance in executive functions, language and memory, and reported higher levels of fatigue. At resting OE state, PCS-pts showed lower delta source activity over brain regions known to be associated with executive processes, and these changes were negatively associated with PDCS scores. Consistent with recent literature data, our findings could indicate a dysfunction in the neuronal networks involved in executive functions in PCS-pts complaining of fatigue and cognitive impairment.

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Section: Introductionmentioning

confidence: 99%

Lowered Delta Activity in Post-COVID-19 Patients with Fatigue and Cognitive Impairment

Quercia

Cerasa

Dezi³

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…It remains to be determined whether these bottom- and top-end neurophysiological techniques can determine in individuals with long Covid, and other conditions with post viral fatigue, the origin of that fatigue, of importance since their treatment may differ. Recently, the clinical neurophysiology of acute and long Covid has been reviewed, although no specific electrodiagnostic signature for SARS-CoV-2 infection could be identified ( Haykal and Menkes, 2023 ).…”

Section: Fatigability In Me/cfs and Long Covidmentioning

confidence: 99%

The role of clinical neurophysiology in the definition and assessment of fatigue and fatigability

Tankisi,

Versace,

Kuppuswamy

et al. 2024

Clinical Neurophysiology Practice

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“…Till date 13.59 billion individuals have been vaccinated [4] Post anti-COVID-19 vaccines neurological issues observed include; seizures, new-onset refractory status epilepticus (NORSE), acute disseminated encephalomyelitis (ADEM), encephalopathy, acute necrotizing encephalopathy, Guillain-Barre syndrome, transverse myelitis, Bell's palsy, myocarditis, pericarditis, headache, intracerebral hemorrhage (ICH) and/or Subarachnoid hemorrhage (SAH), "vaccine-induced immune thrombotic thrombocytopenia/ vaccine-induced prothrombotic immune thrombotic thrombocytopenia" (VITT/VIPITTl) [63][64][65][66][67]. Overall EEGs appear to be clinically useful in evaluating and monitoring seizures, encephalopathy of various etiologies, and cognitive issues associated with long COVID [67][68][69][70][71].…”

Section: Post Anti-covid Vaccinementioning

confidence: 99%

The “Tipping Point” : When Electroencephalography (EEG), Quantitative EEG (QEEG) and Standardized Low Resolution Brain Electromagnetic Tomography (sLORETA) in COVID Went From “Ceasure” To “Non- Priority” To “First-Line” Tool in Triage, Diagnosis, Monitoring and Therapy

Miranda,

Danev,

Alexander

et al. 2024

Neuro Neurosci

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On the threshold of the COVID outbreak; electroencephalography (EEG) was used in diagnosis, crossborder disease differential diagnosis, disease-staging, monitoring of treatment, sedation and coma, in neuro-therapy and in declaration of brain death. EEG, quantitative EEG (QEEG), and standardized low resolution brain electromagnetic tomography (sLORETA) use entered the doldrums; reaching near “ceasure” due to COVID restrictions. Between 2020-2023, EEG use tipped, going from “Ceasure” to “First-Line” tool in triage, diagnosis, monitoring and therapy due to neurological, neurocognitive, neuropsychiatric, and neuromuscular sequelae of para- or acute- and post-COVID-19. The present paper will discuss this “Tipping point” in EEG, QEEG and sLORETA use.

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The clinical neurophysiology of COVID-19-direct infection, long-term sequelae and para-immunization responses: A literature review

Cited by 9 publications

References 103 publications

Lowered Delta Activity in Post-COVID-19 Patients with Fatigue and Cognitive Impairment

Lowered Delta Activity in Post-COVID-19 Patients with Fatigue and Cognitive Impairment

The role of clinical neurophysiology in the definition and assessment of fatigue and fatigability

The “Tipping Point” : When Electroencephalography (EEG), Quantitative EEG (QEEG) and Standardized Low Resolution Brain Electromagnetic Tomography (sLORETA) in COVID Went From “Ceasure” To “Non- Priority” To “First-Line” Tool in Triage, Diagnosis, Monitoring and Therapy

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