The clinical microbiology laboratory as an aid in infection control the application of molecular techniques in epidemiologic studies of methicillin-resistant Staphylococcus aureus

Pfaller, Michael A.; Wakefield, Douglas S.; Hollis, Richard J.; Fredrickson, Mary; Evans, Edward J.; Massanari, R. Michael

doi:10.1016/0732-8893(91)90034-d

Cited by 35 publications

(16 citation statements)

References 38 publications

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“…Five studies were whole hospital studies 56,92,106,112,120 and one dealt with two hospitals. 108 Twelve were studies in hospital units: ICU and general medical ward; 57,78 84 and one was of seven wards in a general hospital.…”

Section: Setting and Populationmentioning

confidence: 99%

“…Five studies 90,95,102,110,112 lasted <1 year (range: 1-9 months); 12 lasted between 1 and 4 years 55,57,78,84,93,97,[106][107][108][109]114,120 one lasted 4 years 4 months 56 and one study described 9 years' experience of MRSA.…”

Section: Length Of Studiesmentioning

confidence: 99%

“…93 There were four prospective single-phase observational studies. 90,106,108,112 There was one retrospective cohort study based on systematically collected survey data with the comparison decided in advance of examination of the data. …”

mentioning

confidence: 99%

“…We considered 11 studies to have designs that are particularly vulnerable to reporting bias. 28,85,87,[98][99][100]103,105,[111][112][113] …”

mentioning

confidence: 99%

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Systematic review of isolation policies in the hospital management of methicillin-resistant Staphylococcus aureus: a review of the literature with epidemiological and economic modelling

Cooper

Stone²,

Kibbler³

et al. 2003

Health Technol Assess

207

102

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Section: Setting and Populationmentioning

confidence: 99%

Section: Length Of Studiesmentioning

confidence: 99%

mentioning

confidence: 99%

“…We considered 11 studies to have designs that are particularly vulnerable to reporting bias. 28,85,87,[98][99][100]103,105,[111][112][113] …”

mentioning

confidence: 99%

See 2 more Smart Citations

Systematic review of isolation policies in the hospital management of methicillin-resistant Staphylococcus aureus: a review of the literature with epidemiological and economic modelling

Cooper

Stone²,

Kibbler³

et al. 2003

Health Technol Assess

207

102

View full text Add to dashboard Cite

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“…2g v 30 In other studies, only the combination of isolation, extended screening, and mupirocin treatment of carriers 3 1 or systemic treatment 32 * 33 was able to contain epidemics. In a long-term prospective study, combined measures were able to terminate several epidemics, to control undetected clusters, and to limit nosocomial transmission.…”

Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology of Methicillin-Resistant Staphyloccocus aureus at a Low-Incidence Hospital over a 4-Year Period

Lugeon¹,

Blanc²,

Wenger³

et al. 1995

Infection Control and Hospital Epidemiology

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OBJECTIVE:To study the epidemiology of methicillinresistant Staphylococcus aureus (MRSA) over a prolonged period of time with the aid of a molecular typing method (ribotyping).SETTING: A 1,000-bed tertiary university medical center.PATIENTS AND METHODS: Defined epidemiological data were recorded for all patients culture-positive for MRSA between 1989 and 1992. Ribotyping of MRSA strains was performed using three restriction enzymes: EcoRv, HindHI, and KpnI.RESULTS: From 1989 to 1992, MRSA was isolated from clinical specimens in 98 patients and from surveillance cultures in 27 patients. Among the 122 isolates available for typing, 26 different ribotypes were identified. In 20% of the cases, MRSA was community-acquired, and a third of these patients never had been hospitalized previously. Nine ribotypes were responsible for more than one case (2 to 64 patients); 17 appeared only once. Epidemiological data correlated with ribotyping results revealed 14 epidemiologic clusters involving six different ribotypes, whereas only three outbreaks were suspected initially. The median follow-up after the last isolation of a given ribotype was 14 months (range, 1 to 42) for clusters and 25 months (range, 1 to 46) for ribotypes that appeared only once. During clusters, only 16% of the cases occurred after the implementation of control measures in the ward (breakthrough cases).CONCLUSIONS: The high diversity of MRSA strains observed over 4 years suggested that new strains were introduced continuously in our hospital. Furthermore, that 17 ribotypes were isolated only once, that breakthrough cases represented only 16% of the cases in clusters, and that the follow-up duration after the last isolation of a given ribotype was more than 14 months suggest that infection control measures were effective in limiting the nosocomial spread of MRSA over a prolonged period of time (Infect Control Hasp Epidemiol1995;16:260-267).

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Value of Molecular Epidemiologic Analysis in a Nosocomial Methicillin-Resistant Staphylococcus aureus Outbreak

Fang

McClelland

Guiney

et al. 1993

JAMA

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The clinical microbiology laboratory as an aid in infection control the application of molecular techniques in epidemiologic studies of methicillin-resistant Staphylococcus aureus

Cited by 35 publications

References 38 publications

Systematic review of isolation policies in the hospital management of methicillin-resistant Staphylococcus aureus: a review of the literature with epidemiological and economic modelling

Systematic review of isolation policies in the hospital management of methicillin-resistant Staphylococcus aureus: a review of the literature with epidemiological and economic modelling

Molecular Epidemiology of Methicillin-Resistant Staphyloccocus aureus at a Low-Incidence Hospital over a 4-Year Period

Value of Molecular Epidemiologic Analysis in a Nosocomial Methicillin-Resistant Staphylococcus aureus Outbreak

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