The clinical importance of hypochlorhydria (a consequence of chronic Helicobacter infection): Its possible etiological role in mineral and amino acid malabsorption, depression, and other syndromes

Cater, Ruth

doi:10.1016/0306-9877(92)90065-k

Cited by 17 publications

(6 citation statements)

References 36 publications

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“…Indeed, because nitrogen in the colonic lumen is intensely metabolized by the bacterial flora, absorbed and secreted, faecal nitrogen digestibility may differ markedly from ileal nitrogen digestibility 8 –10 , . 22 This has been confirmed in an animal study in which the faecal and ileal digestibility were evaluated simultaneously 23 …”

Section: Discussionmentioning

confidence: 78%

Evidence for impaired assimilation and increased colonic fermentation of protein, related to gastric acid suppression therapy

Evenepoel

Claus

Geypens

et al. 1998

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 78%

Evidence for impaired assimilation and increased colonic fermentation of protein, related to gastric acid suppression therapy

Evenepoel

Claus

Geypens

et al. 1998

Aliment Pharmacol Ther

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“…It is inferred that the lack of gastric pepsin and acid may impair protein digestion due to the decreased stimulation of the pancreas and bacterial overgrowth in the duodenum. [ 14 ] Another possible explanation may be related to the decreased production of gastric ghrelin in patients with atrophic gastritis. Ghrelin is predominantly produced by the P/D1 cells of gastric oxyntic gland and can increase appetite and induce a positive energy homeostasis leading to weight gain.…”

Section: Discussionmentioning

confidence: 99%

Low PG I/II ratio as a marker of atrophic gastritis

Su¹,

Zhou²,

Qin

et al. 2018

Medicine

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A low pepsinogen (PG) I/II ratio can be used to detect atrophic gastritis (AG). Recent research has found that the PG I/II ratio is associated with several nutritional and metabolic disorders. The aim of this study is to investigate the relationship between the PG I/II ratio and biochemical markers in a Chinese population.In total, 1896 participants in a gastric cancer screening program underwent a health screening test that included assessment of serum pepsinogens. Subjects with PG I/II < 3.0 were considered as having atrophic gastritis. Associations between the PG I/II ratio and biochemical markers reflecting glucose and lipid metabolism, liver, kidney and thyroid functions were evaluated using SPSS software version 20.The prevalence of atrophic gastritis was 5.3% and increased with age but did not differ between sexes. Albumin, ferritin, and total and direct bilirubin were significantly lower in patients with AG than in those without AG, whereas age, total bile acid, and amylase were significantly higher. Albumin, ferritin, and triglyceride correlated positively with the PG I/II ratio, while age, total bile acid, blood urea nitrogen, amylase, aspartate aminotransferase, creatine kinase, and lactate dehydrogenase correlated inversely with the PG I/II ratio. Logistic regression analysis demonstrated that age, total bile acid, total protein, and ferritin correlated independently with AG.Low PG I/II ratio is not only a marker of atrophic gastritis but also an indicator of nutritional and metabolic status. Special attention should be paid to the metabolism of iron, protein, and bile acid in patients with a low PG I/II ratio.

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“…This is diagnosable with a serological test and curable with a course of antibiotics. Aggressive diagnosis and treatment of other low-grade diseases such as allergic conditions (Sugarman, Southern, & Curran, 1982), subclinical hypothyroidism (Lasser & Baldessarini, 1997), hypochlorhydria (Cater, 1992), fructose malabsorption (Ledochowski, Widner, Bair, Probst, & Fuchs, 2000), nutrient deficiencies (Carney, Ravindran, Rinsler, & Williams, 1982), and mild heavy metal poisoning (Balestra, 1991) have yielded results in otherwise intractable cases of depression.…”

Section: Medical Conditions Associated With Depressionmentioning

confidence: 99%