2018
DOI: 10.1097/md.0000000000010820
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Low PG I/II ratio as a marker of atrophic gastritis

Abstract: A low pepsinogen (PG) I/II ratio can be used to detect atrophic gastritis (AG). Recent research has found that the PG I/II ratio is associated with several nutritional and metabolic disorders. The aim of this study is to investigate the relationship between the PG I/II ratio and biochemical markers in a Chinese population.In total, 1896 participants in a gastric cancer screening program underwent a health screening test that included assessment of serum pepsinogens. Subjects with PG I/II < 3.0 were considered … Show more

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Cited by 13 publications
(9 citation statements)
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“…Most of the synthetic PG is released into the gastric cavity, and only about 1% enter the blood circulation 9 . In ideal state, serum PG can accurately reflect the state of gastric mucosal lesion 10 12 . G-17 is an important gastrointestinal peptide hormone and produced in the antrum by G cells, which is correlated with the position and degree of gastric mucosal atrophy.…”
Section: Introductionmentioning
confidence: 99%
“…Most of the synthetic PG is released into the gastric cavity, and only about 1% enter the blood circulation 9 . In ideal state, serum PG can accurately reflect the state of gastric mucosal lesion 10 12 . G-17 is an important gastrointestinal peptide hormone and produced in the antrum by G cells, which is correlated with the position and degree of gastric mucosal atrophy.…”
Section: Introductionmentioning
confidence: 99%
“…We observed that the success of WMT in eradicating H. pylori infection appeared to be associated with an increased PGR detected within 1 week prior to WMT. It has been demonstrated that a low PGR is a biomarker of precancerous lesions, such as atrophic gastritis, and thus indicates a high risk of developing gastric cancer [ 34 36 ]. Our observation suggests that WMT may have a therapeutic effect on H. pylori infection in patients with low risk of gastric cancer and those with high risk of gastric cancer may not benefit from WMT.…”
Section: Discussionmentioning
confidence: 99%
“…The main function of G-17 is to stimulate the secretion of gastric acid by the parietal cells of the gastric body, as well as to increase the motility of the gastric antrum. Thus, serum PG levels, primarily the combination of PG-I and PGR, with or without G-17 and HP-IgG determination, can be used to reflect morphological aspects, the functional (secretory) state of the gastric mucosa and to predict the development of GC [ 4 , 6 – 11 , 14 16 , 29 , 32 35 ].…”
Section: Serological Examinationmentioning
confidence: 99%
“…PGR was inversely correlated with CAG (transparency of blood vessels with a demarcation line - atrophic border) and IM (whitish spots with or without depressed hyperemic lesions) (p<0.001) [ 57 ]. PGR is closely correlated with histological CAG, and PGR<3.0 is considered an optimal value for the diagnosis of CAG with high sensitivity (71%), specificity (86%) and PPV (85%) [ 11 ]. A significant correlation was found between CAG, determined endoscopically and histologically, and the sensitivity and specificity of the endoscopic diagnosis were 65.9% and 58.0% for the gastric antrum, 71.3% and 53.7% for the gastric body, respectively [ 55 ].…”
Section: Comparison Of Endoscopic/histological and Serological Examinmentioning
confidence: 99%
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